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The Journal of Obstetrics and Gynecology of India

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01-02-2020 | Infertility | Original Article

Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia

Authors: Leena Wadhwa, Srishti Priyadarshini, Ashish Fauzdar, Sanjana N. Wadhwa, Sarika Arora

Published in: The Journal of Obstetrics and Gynecology of India | Issue 1/2020

Abstract

Introduction

Male factor contributes to almost 50% cases of infertility. There is evidence of the effect of serum vitamin D on male fertility by helping in spermatozoa maturation and initiating acrosomal reaction. In India, vitamin D deficiency has been documented to be in the range of 50–90% among all the age groups.

Objective

To study the levels of vitamin D and the impact of vitamin D supplementation in vitamin D-insufficient/deficient infertile males with oligoasthenozoospermia.

Material and methods

This study is a longitudinal observation study. Infertile men with either oligozoospermia or asthenozoospermia with vitamin D levels < 30 ng/ml were enrolled. Vitamin D and calcium supplementation was given, and semen and hormone parameters were assessed at the end of 3 and 6 months.

Result

There is significant improvement in the mean sperm concentration and progressive sperm motility in infertile males with oligoasthenozoospermia after 6 months of vitamin D supplementation (p value < 0.001). The overall clinical pregnancy rate in the study was 8.33% after vitamin D supplementation (p value 0.24).

Conclusion

Vitamin D supplementation plays a crucial role in regulating male fertility.

Calverton, Maryland, USA: ORC Macro and the World Health Organization; 2004. World Health Organization. Infecundity, Infertility, and Childlessness in Developing Countries. DHS Comparative Reports No 9.

Anthony H. Male subfertility. BMJ. 2003;327(7416):669–72.CrossRef

Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology. 2006;68:1345–9.CrossRef

Jensen BM, Jorgensen A, Nielsen JE, et al. Expression of the vitamin D metabolizing enzyme CYP21A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int J Androl. 2012;35(4):499–510.CrossRef

Harinarayan CV, Joshi SR. Vitamin D status in India—its implications and remedial measures. J Assoc Physicians India. 2009;57:40–8.PubMed

Ramlau-Hansen CH, Moeller UK, Bonde JP, et al. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril. 2011;95:1000–4.CrossRef

Jensen BM, Bjerrum PJ, Jessen TE, et al. vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. 2011;26:1307–17.CrossRef

Özdemir E, Tokmak A, Erkılınç S, et al. Association between vitamin D levels and semen parameters in infertile males. J Clin Anal Med. 2015;6:765–9.

Jensen BM, GernerLawaetz J, Andersson A, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod. 2016;31(8):1875–85.CrossRef

10.

Hammoud A, Meikle A, Matthew CP, et al. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. 2012;14(6):855–9.CrossRef

11.

Deng XL, Li YM, Yang XY, et al. Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia. Zhonghua Nan KeXue. 2014;20(12):1082–5.

12.

Jensen BM, Lawaetz JG, Petersen JH, et al. Effects of vitamin D supplementation on semen quality, reproductive hormones, and live birth rate: a randomized clinical trial. J Clin Endocrinol Metab. 2018;103(3):870–81.CrossRef

13.

Lerchbaum E, Pilz S, Trummer C, et al. Serum vitamin D levels and hypogonadism in men. Int J Andrology. 2014;2:748–54.CrossRef

14.

Lee DM, Tajar A, Pye SR, et al. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol. 2012;166:77–8.CrossRef

15.

Pilz S, Frisch S, Koertke H, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011;43(3):223–5.CrossRef

Title: Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia
Authors: Leena Wadhwa
Srishti Priyadarshini
Ashish Fauzdar
Sanjana N. Wadhwa
Sarika Arora
Publication date: 01-02-2020
Publisher: Springer India
Keywords: Infertility
Infertility
Vitamin D Deficiency
Testosterone
Published in: The Journal of Obstetrics and Gynecology of India / Issue 1/2020
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI: https://doi.org/10.1007/s13224-019-01251-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia

Abstract

Introduction

Objective

Material and methods

Result

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Objective

Material and methods

Result

Conclusion

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