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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 5/2024

Open Access 19-03-2024 | Tension Headache | Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

Research Progress on the Experimental Model and Underlying Mechanistic Studies of Tension-Type Headaches

Authors: Guo-jing Fu, liu-ding Wang, Xian-su Chi, Xiao Liang, Jing-jing Wei, Zhi-hong Huang, Wei Shen, Yun-ling Zhang

Published in: Current Pain and Headache Reports | Issue 5/2024

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Abstract

Purpose of Review

Tension-type headaches (TTH) significantly diminish patients’ quality of life and increase absenteeism, thereby imposing a substantial economic burden. Animal models are essential tools for studying disease mechanisms and drug development. However, until now, little focus has been placed on summarizing the animal models of TTH and associated mechanistic studies. This narrative review discusses the current animal models of TTH and related mechanistic studies to provide insights into the pathophysiological mechanisms of and treatments for TTH.

Recent Findings

The primary method for constructing an animal model of TTH involves injecting a solution of pain relievers, such as adenosine triphosphate, nerve growth factor, or a high concentration of salt solution, into the neck to initiate harmful cervical muscle responses. This model enables the examination of the interaction between peripheral muscles and central sensitization, which is crucial for understanding the pathophysiology of TTH. Mechanistic studies based on this model have investigated the effect of the P2X receptor antagonist, P2X7 receptor blockade, the P2Y1 receptor agonist 2-MESADP, P2Y1 receptor antagonist MRS2179, nitric oxide synthase inhibitors, and acetylsalicylic acid.

Summary

Despite notable advancements, the current model of TTH has limitations, including surgical complexity and the inability to replicate chronic tension-type headache (CTTH). To gain a more comprehensive understanding and develop more effective treatment methods, future studies should focus on simplifying surgical procedures, examining other predisposing factors, and establishing a model for chronic TTH. This will offer a deeper insight into the pathophysiological mechanism of TTH and pave the way for improved treatment approaches.
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Metadata
Title
Research Progress on the Experimental Model and Underlying Mechanistic Studies of Tension-Type Headaches
Authors
Guo-jing Fu
liu-ding Wang
Xian-su Chi
Xiao Liang
Jing-jing Wei
Zhi-hong Huang
Wei Shen
Yun-ling Zhang
Publication date
19-03-2024
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 5/2024
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-024-01238-2

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