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Open Access 01-12-2020 | Letter to the Editor

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis

Authors: Conceição Bettencourt, Ignazio S. Piras, Sandrine C. Foti, Joshua Talboom, Yasuo Miki, Tammaryn Lashley, Robert Balazs, Emmanuelle Viré, Thomas T. Warner, Matt J. Huentelman, Janice L. Holton

Published in: Acta Neuropathologica Communications | Issue 1/2020

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To the Editors, …

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Bettencourt C, Foti SC, Miki Y, Botia J, Chatterjee A, Warner TT, Revesz T, Lashley T, Balazs R, Vire E et al (2020) White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Acta Neuropathol 139:135–156. https://doi.org/10.1007/s00401-019-02074-0 CrossRefPubMed

Kiely AP, Murray CE, Foti SC, Benson BC, Courtney R, Strand C, Lashley T, Holton JL (2018) Immunohistochemical and molecular investigations show alteration in the inflammatory profile of multiple system atrophy brain. J Neuropathol Exp Neurol 77:598–607. https://doi.org/10.1093/jnen/nly035 CrossRefPubMedPubMedCentral

Papp MI, Kahn JE, Lantos PL (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and shy-Drager syndrome). J Neurol Sci 94:79–100CrossRef

Piras IS, Bleul C, Schrauwen I, Talboom J, Llaci L, De Both MD, Naymik MA, Halliday G, Bettencourt C, Holton JL et al (2020) Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease. bioRxiv https://www.biorxiv.org/content/10.1101/2020.02.11.944306v1. Accessed 12 Feb 2020.

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Title: Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis
Authors: Conceição Bettencourt
Ignazio S. Piras
Sandrine C. Foti
Joshua Talboom
Yasuo Miki
Tammaryn Lashley
Robert Balazs
Emmanuelle Viré
Thomas T. Warner
Matt J. Huentelman
Janice L. Holton
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: Acta Neuropathologica Communications / Issue 1/2020
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-020-00946-1

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Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis

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