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01-08-2021 | Giant Cell Arteritis | Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)

Monckeberg’s Medial Sclerosis as a Cause for Headache and Facial Pain

Authors: Davis C. Thomas, Prisly Thomas, Anilkumar Sivan, Priyanka Unnam, Ahana Ajayakumar, Sanjana Santhosh Kumar, Priyanka Kodaganallur Pitchumani, Mahnaz Fatahzadeh, Nida-e-Haque Mahmud

Published in: Current Pain and Headache Reports | Issue 8/2021

Abstract

Purpose of Review

Mönckeberg’s medial sclerosis (MMS) is a chronic, non-inflammatory degenerative condition affecting primarily the tunica media of muscular arteries resulting in their calcification. The purpose of this comprehensive review is to describe MMS as it appears in the literature, in the context of headache and facial pain. Understanding the etiopathology, the associated conditions, and the differential diagnoses is important in managing MMS.

Recent Findings

Management of MMS primarily depends upon identification of its associated conditions and their treatment. Due to the rare incidence and inadequate literature on MMS presenting with headaches, the diagnosis of the pain and the entity itself is challenging.

Summary

MMS is characterized by associated systemic conditions and absence of inflammatory markers. It can mimic giant cell arteritis (GCA) and other pain entities. An interdisciplinary approach involving appropriate specialties is recommended.

Micheletti RG, Fishbein GA, Currier JS, Singer EJ, Fishbein MC. Calcification of the internal elastic lamina of coronary arteries. Mod Pathol. 2008;21(8):1019–28. https://doi.org/10.1038/modpathol.2008.89.CrossRefPubMedPubMedCentral

Couri CE, da Silva GA, Martinez JA, Pereira Fde A, de Paula FJ. Mönckeberg’s sclerosis - is the artery the only target of calcification? BMC Cardiovasc Disord. 2005;5:34. https://doi.org/10.1186/1471-2261-5-34.CrossRefPubMedPubMedCentral

•• Cuevas Castillo FJ, Sujanani S, Chetram VK, Elfishawi M, Abrudescu A. Monckeberg medial calcific sclerosis of the temporal artery masquerading as giant cell arteritis: case reports and literature review. Cureus. 2020;12(7):e9210. https://doi.org/10.7759/cureus.9210This article includes a summary of reported cases in the literature.CrossRefPubMedPubMedCentral

Castling B, Bhatia S, Ahsan F. Mönckeberg’s arteriosclerosis: vascular calcification complicating microvascular surgery. Int J Oral Maxillofac Surg. 2015;44(1):34–6. https://doi.org/10.1016/j.ijom.2014.10.011.CrossRefPubMed

Dogan A, Sever K, Mansuroglu D, Hacisalihoglu P, Kurtoglu N. Mönckeberg’s arteriosclerosis: a possible reason for non-use of radial conduit. Asian Cardiovasc Thorac Ann. 2019;27(8):685–7. https://doi.org/10.1177/0218492319841977.CrossRefPubMed

•• Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, et al. Medial vascular calcification revisited: review and perspectives. Eur Heart J. 2014;35(23):1515–25. https://doi.org/10.1093/eurheartj/ehu163This is one of the most comprehensive reviews on MMS including pathophysiology, clinical features, diagnosis, and management of MMS.CrossRefPubMedPubMedCentral

Frazier JJ, Casian R, Benson BW. Mönckeberg medial calcinosis of the infraorbital arteries: a first case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(2):e31–e5. https://doi.org/10.1016/j.oooo.2017.11.014.CrossRefPubMed

Naha K, Shetty RK, Vivek G, Reddy S. Incidentally detected Monckeberg’s sclerosis in a diabetic with coronary artery disease. BMJ Case Rep. 2012;2012:bcr2012007376. https://doi.org/10.1136/bcr-2012-007376.CrossRefPubMedPubMedCentral

Tahmasbi-Arashlow M, Barghan S, Kashtwari D, Nair MK. Radiographic manifestations of Mönckeberg arteriosclerosis in the head and neck region. Imaging Sci Dent. 2016;46(1):53–6. https://doi.org/10.5624/isd.2016.46.1.53.CrossRefPubMedPubMedCentral

10.

Lachman AS, Spray TL, Kerwin DM, Shugoll GI, Roberts WC. Medial calcinosis of Mönckeberg. A review of the problem and a description of a patient with involvement of peripheral, visceral and coronary arteries. Am J Med. 1977;63(4):615–22. https://doi.org/10.1016/0002-9343(77)90207-8.CrossRefPubMed

11.

Shioi A, Taniwaki H, Jono S, Okuno Y, Koyama H, Mori K, et al. Mönckeberg’s medial sclerosis and inorganic phosphate in uremia. Am J Kidney Dis. 2001;38(4 Suppl 1):S47–9. https://doi.org/10.1053/ajkd.2001.27396.CrossRefPubMed

12.

Top C, Cankir Z, Silit E, Yildirim S, Danaci M. Mönckeberg’s sclerosis: an unusual presentation--a case report. Angiology. 2002;53(4):483–6. https://doi.org/10.1177/000331970205300418.CrossRefPubMed

13.

Xu X, Zhang M, Fei Z, Sheng H, Qu S, Cui R. Calcification of lower extremity arteries is related to the presence of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a cross-sectional observational study. Osteoporos Int. 2021. https://doi.org/10.1007/s00198-020-05775-5.

14.

Fishbein GA, Fishbein MC. Arteriosclerosis: rethinking the current classification. Arch Pathol Lab Med. 2009;133(8):1309–16. https://doi.org/10.1043/1543-2165-133.8.1309.CrossRefPubMed

15.

Amos RS, Wright V. Mönckeberg’s arteriosclerosis and metabolic bone disease. Lancet. 1980;2(8188):248–9. https://doi.org/10.1016/s0140-6736(80)90133-6.CrossRefPubMed

16.

Kalbak K. Incidence of arteriosclerosis in patients with rheumatoid arthritis receiving long-term corticosteroid therapy. Ann Rheum Dis. 1972;31(3):196–200. https://doi.org/10.1136/ard.31.3.196.CrossRefPubMedPubMedCentral

17.

Fuchs U, Caffier P, Schulz HG, Wieniecki P. Arterial calcification in diabetics. Virchows Arch A Pathol Anat Histopathol. 1985;407(4):431–9. https://doi.org/10.1007/bf00709989.CrossRefPubMed

18.

Micheletti RG, Fishbein GA, Currier JS, Fishbein MC. Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis. Arch Pathol Lab Med. 2008;132(1):43–7. https://doi.org/10.1043/1543-2165(2008)132[43:Msraco]2.0.Co;2.CrossRefPubMed

19.

Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, et al. Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol. 1998;31(1):126–33. https://doi.org/10.1016/s0735-1097(97)00443-9.CrossRefPubMed

20.

Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res. 2006;99(10):1044–59. https://doi.org/10.1161/01.Res.0000249379.55535.21.CrossRefPubMed

21.

Speer MY, Yang HY, Brabb T, Leaf E, Look A, Lin WL, et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res. 2009;104(6):733–41. https://doi.org/10.1161/circresaha.108.183053.CrossRefPubMedPubMedCentral

22.

Giachelli CM. The emerging role of phosphate in vascular calcification. Kidney Int. 2009;75(9):890–7. https://doi.org/10.1038/ki.2008.644.CrossRefPubMedPubMedCentral

23.

Zhu D, Mackenzie NC, Farquharson C, Macrae VE. Mechanisms and clinical consequences of vascular calcification. Front Endocrinol (Lausanne). 2012;3:95. https://doi.org/10.3389/fendo.2012.00095.CrossRef

24.

Goebel FD, Füessl HS. Mönckeberg’s sclerosis after sympathetic denervation in diabetic and non-diabetic subjects. Diabetologia. 1983;24(5):347–50. https://doi.org/10.1007/bf00251822.CrossRefPubMed

25.

Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Laakso M. Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol. 1996;16(8):978–83. https://doi.org/10.1161/01.atv.16.8.978.CrossRefPubMed

26.

Lindbom A. Arteriosclerosis and arterial thrombosis in the lower limb; a roentgenological study. Acta Radiol Suppl. 1950;80:1–80.PubMed

27.

Orr DP, Myerowitz RL, Herbert DL, Friday P. Correlation of radiographic and histologic findings in arterial calcification. Investig Radiol. 1978;13(2):110–4. https://doi.org/10.1097/00004424-197803000-00002.CrossRef

28.

Zwakenberg SR, de Jong PA, Hendriks EJ, Westerink J, Spiering W, de Borst GJ, et al. Intimal and medial calcification in relation to cardiovascular risk factors. PLoS One. 2020;15(7):e0235228. https://doi.org/10.1371/journal.pone.0235228.CrossRefPubMedPubMedCentral

29.

Hendriks EJE, Beulens JWJ, Mali W, Beijerinck D, van der Graaf Y, de Jong PA, et al. Breast arterial calcifications and their association with incident cardiovascular disease and diabetes: the Prospect-EPIC cohort. J Am Coll Cardiol. 2015;65(8):859–60. https://doi.org/10.1016/j.jacc.2014.12.015.CrossRefPubMed

30.

Niskanen L, Siitonen O, Suhonen M, Uusitupa MI. Medial artery calcification predicts cardiovascular mortality in patients with NIDDM. Diabetes Care. 1994;17(11):1252–6. https://doi.org/10.2337/diacare.17.11.1252.CrossRefPubMed

31.

Markello TC, Pak LK, St Hilaire C, Dorward H, Ziegler SG, Chen MY, et al. Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab. 2011;103(1):44–50. https://doi.org/10.1016/j.ymgme.2011.01.018.CrossRefPubMedPubMedCentral

32.

Kröger K. Epidemiology of peripheral arterial disease in Germany. What is evident, what remains unclear? Hamostaseologie. 2006;26(3):193–6.CrossRef

33.

Ho CY, Shanahan CM. Medial arterial calcification: an overlooked player in peripheral arterial disease. Arterioscler Thromb Vasc Biol. 2016;36(8):1475–82. https://doi.org/10.1161/atvbaha.116.306717.CrossRefPubMed

34.

London GM, Guérin AP, Marchais SJ, Métivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant. 2003;18(9):1731–40. https://doi.org/10.1093/ndt/gfg414.CrossRefPubMed

35.

Michaux A, Matagrin B, Debaux JV, Schurgers LJ, Benoit E, Lattard V. Missense mutation of VKORC1 leads to medial arterial calcification in rats. Sci Rep. 2018;8(1):13733. https://doi.org/10.1038/s41598-018-31788-6.CrossRefPubMedPubMedCentral

36.

Oldenburg J, Marinova M, Müller-Reible C, Watzka M. The vitamin K cycle. Vitam Horm. 2008;78:35–62. https://doi.org/10.1016/s0083-6729(07)00003-9.CrossRefPubMed

37.

St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, et al. NT5E mutations and arterial calcifications. N Engl J Med. 2011;364(5):432–42. https://doi.org/10.1056/NEJMoa0912923.CrossRefPubMedPubMedCentral

38.

De Vilder EY, Vanakker OM. From variome to phenome: pathogenesis, diagnosis and management of ectopic mineralization disorders. World J Clin Cases. 2015;3(7):556–74. https://doi.org/10.12998/wjcc.v3.i7.556.CrossRefPubMedPubMedCentral

39.

• Zazzeroni L, Faggioli G, Pasquinelli G. Mechanisms of arterial calcification: the role of matrix vesicles. Eur J Vasc Endovasc Surg. 2018;55(3):425–32. https://doi.org/10.1016/j.ejvs.2017.12.009Contains a good explanation of the mechanisms of vascular calcifications and associated histopathology.CrossRefPubMed

40.

Tentolouris C, Kontozoglou T, Toutouzas P. Familial calcification of aorta and calcific aortic valve disease associated with immunologic abnormalities. Am Heart J. 1993;126(4):904–9. https://doi.org/10.1016/0002-8703(93)90705-e.CrossRefPubMed

41.

Omami G. Monckeberg arteriosclerosis: a telltale sign. J Oral Maxillofac Surg. 2017;75(11):2383–4. https://doi.org/10.1016/j.joms.2017.04.007.CrossRefPubMed

42.

Aitken E, Ramjug S, Buist L, Kingsmore D. The prognostic significance of iliac vessel calcification in renal transplantation. Transplant Proc. 2012;44(10):2925–31. https://doi.org/10.1016/j.transproceed.2012.06.058.CrossRefPubMed

43.

Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM. Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res. 2011;109(6):697–711. https://doi.org/10.1161/circresaha.110.234914.CrossRefPubMedPubMedCentral

44.

Drüeke TB, Massy ZA. Role of vitamin D in vascular calcification: bad guy or good guy? Nephrol Dial Transplant. 2012;27(5):1704–7. https://doi.org/10.1093/ndt/gfs046.CrossRefPubMed

45.

Prasad R, Devasia T, Kareem H, Kumar A. Non-healing ulcer of right foot due to Monckeberg’s arteriosclerosis. BMJ Case Rep. 2015;2015. https://doi.org/10.1136/bcr-2014-208047.

46.

Atkinson J. Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences. J Appl Physiol (1985). 2008;105(5):1643–51. https://doi.org/10.1152/japplphysiol.90476.2008.CrossRef

47.

Leopold JA. Vascular calcification: an age-old problem of old age. Circulation. 2013;127(24):2380–2. https://doi.org/10.1161/circulationaha.113.003341.CrossRefPubMedPubMedCentral

48.

Danziger J. Vitamin K-dependent proteins, warfarin, and vascular calcification. Clin J Am Soc Nephrol. 2008;3(5):1504–10. https://doi.org/10.2215/cjn.00770208.CrossRefPubMedPubMedCentral

49.

Schurgers LJ, Aebert H, Vermeer C, Bültmann B, Janzen J. Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood. 2004;104(10):3231–2. https://doi.org/10.1182/blood-2004-04-1277.CrossRefPubMed

50.

Ino T, Shimazaki S, Akimoto K, Park I, Nishimoto K, Yabuta K, et al. Coronary artery calcification in Kawasaki disease. Pediatr Radiol. 1990;20(7):520–3. https://doi.org/10.1007/bf02011380.CrossRefPubMed

51.

Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Höhne W, et al. Mutations in ENPP1 are associated with ‘idiopathic’ infantile arterial calcification. Nat Genet. 2003;34(4):379–81. https://doi.org/10.1038/ng1221.CrossRefPubMed

52.

Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, et al. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet. 2012;44(3):254–6. https://doi.org/10.1038/ng.1077.CrossRefPubMed

53.

Paccou J, Brazier M, Mentaverri R, Kamel S, Fardellone P, Massy ZA. Vascular calcification in rheumatoid arthritis: prevalence, pathophysiological aspects and potential targets. Atherosclerosis. 2012;224(2):283–90. https://doi.org/10.1016/j.atherosclerosis.2012.04.008.CrossRefPubMed

54.

Famularo G, Ceralli F, Sensi F, Gasbarrone L, Minisola G. SAPHO and Mönckeberg’s sclerosis: two rare diseases and one patient. Clin Exp Rheumatol. 2016;34(2):354.PubMed

55.

Son CN, Jung KH, Song SY, Jun JB. Monckeberg’s sclerosis in a patient with systemic sclerosis. Rheumatol Int. 2009;30(1):105–7. https://doi.org/10.1007/s00296-009-0896-5.CrossRefPubMed

56.

Castillo BV Jr, Torczynski E, Edward DP. Monckeberg’s sclerosis in temporal artery biopsy specimens. Br J Ophthalmol. 1999;83(9):1091–2. https://doi.org/10.1136/bjo.83.9.e1088.CrossRefPubMed

57.

Belliveau MJ, Almeida DR, Eneh A, Farmer J. Mönckeberg medial calcific sclerosis mimicking giant cell arteritis clinically. Can J Ophthalmol. 2013;48(1):71–2. https://doi.org/10.1016/j.jcjo.2012.09.013.CrossRefPubMed

58.

Phelps PO, Surapaneni KR, Potter HD. Monckeberg’s arteriosclerosis in temporal arteritis suspect. Ophthalmology. 2015;122(6):1186. https://doi.org/10.1016/j.ophtha.2014.12.023.CrossRefPubMed

59.

Speer MY, Giachelli CM. Regulation of cardiovascular calcification. Cardiovasc Pathol. 2004;13(2):63–70. https://doi.org/10.1016/s1054-8807(03)00130-3.CrossRefPubMed

60.

Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu DT, Vyavahare NR. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006;168(2):490–8. https://doi.org/10.2353/ajpath.2006.050338.CrossRefPubMedPubMedCentral

61.

Saxena A, Waddell IC, Friesen RW, Michalski RT. Monckeberg medial calcific sclerosis mimicking malignant calcification pattern at mammography. J Clin Pathol. 2005;58(4):447–8.PubMedPubMedCentral

62.

Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol. 2008;3(6):1599–605. https://doi.org/10.2215/cjn.02120508.CrossRefPubMed

63.

Kadoya Y, Yanishi K, Matoba S. Rail-tracking calcification of lower limb arteries. Clin Case Rep. 2018;6(9):1921–2. https://doi.org/10.1002/ccr3.1767.CrossRefPubMedPubMedCentral

64.

Quirce R, Martínez-Rodríguez I, Banzo I, de Arcocha-Torres M, Jiménez-Bonilla JF, Martínez-Amador N, et al. (18)F-sodium fluoride PET/CT for the in vivo visualization of Mönckeberg’s sclerosis in a diabetic patient. Rev Esp Med Nucl Imagen Mol. 2015;34(5):314–6. https://doi.org/10.1016/j.remn.2015.04.004.CrossRefPubMed

65.

Vijayan S, Potluri A. Case of Mönckeberg arteriosclerosis in the carotid, facial, and lingual arteries: a potentially serious incidental finding in CBCT. Gen Dent. 2020;68(5):47–50.PubMed

66.

Shahid K, Weng S, Cook L, Syed AZ. Detection of Monckeberg medial sclerosis on conventional dental imaging. J Mich Dent Assoc. 2017;99(3):40–2 68-9.PubMed

67.

Liu KH, Chu WC, Kong AP, Choi Ko GT, Ma RC, Chan JW, et al. US assessment of medial arterial calcification: a sensitive marker of diabetes-related microvascular and macrovascular complications. Radiology. 2012;265(1):294–302. https://doi.org/10.1148/radiol.12112440.CrossRefPubMed

68.

Chrysidis S, Duftner C, Dejaco C, Schäfer VS, Ramiro S, Carrara G, et al. Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group. RMD Open. 2018;4(1):e000598. https://doi.org/10.1136/rmdopen-2017-000598.CrossRefPubMedPubMedCentral

69.

• Monti S, Bond M, Felicetti M, Cavallaro E, Posarelli C, Elefante E, et al. One year in review 2019: vasculitis. Clin Exp Rheumatol. 2019;37(Suppl 117(2)):3–19 Descriptive article dealing with the pathogenesis, clinical features, and current modalities of management.PubMed

70.

Roncato C, Perez L, Brochet-Guégan A, Allix-Béguec C, Raimbeau A, Gautier G, et al. Colour Doppler ultrasound of temporal arteries for the diagnosis of giant cell arteritis: a multicentre deep learning study. Clin Exp Rheumatol. 2020;38(Suppl 124(2)):120–5.PubMed

71.

Schmidt WA, Kraft HE, Vorpahl K, Völker L, Gromnica-Ihle EJ. Color duplex ultrasonography in the diagnosis of temporal arteritis. N Engl J Med. 1997;337(19):1336–42. https://doi.org/10.1056/nejm199711063371902.CrossRefPubMed

72.

Disthabanchong S. Lowering vascular calcification burden in chronic kidney disease: Is it possible? World J Nephrol. 2013;2(3):49–55. https://doi.org/10.5527/wjn.v2.i3.49.CrossRefPubMedPubMedCentral

73.

Lang F, Ritz E, Voelkl J, Alesutan I. Vascular calcification--is aldosterone a culprit? Nephrol Dial Transplant. 2013;28(5):1080–4. https://doi.org/10.1093/ndt/gft041.CrossRefPubMed

74.

O’Neill WC, Lomashvili KA. Recent progress in the treatment of vascular calcification. Kidney Int. 2010;78(12):1232–9. https://doi.org/10.1038/ki.2010.334.CrossRefPubMedPubMedCentral

75.

Riccardi D, Kemp PJ. The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease. Annu Rev Physiol. 2012;74:271–97. https://doi.org/10.1146/annurev-physiol-020911-153318.CrossRefPubMed

76.

Flore R, Ponziani FR, Di Rienzo TA, Zocco MA, Flex A, Gerardino L, et al. Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. Eur Rev Med Pharmacol Sci. 2013;17(18):2433–40.PubMed

77.

Hristova M, van Beek C, Schurgers LJ, Lanske B, Danziger J. Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation. Am J Kidney Dis. 2010;56(6):1158–62. https://doi.org/10.1053/j.ajkd.2010.06.017.CrossRefPubMedPubMedCentral

78.

Pisani I, De Troia A, Allegri L, Corradi D, Vaglio A. Malignant Mönckeberg medial calcific sclerosis. Intern Emerg Med. 2018;13(4):615–7. https://doi.org/10.1007/s11739-018-1794-1.CrossRefPubMed

79.

Don BR, Chin AI. A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol. 2003;59(6):463–70. https://doi.org/10.5414/cnp59463.CrossRefPubMed

80.

Sorensen MD, Long LO, Wessells H, Kuan JK. Monckeberg’s calciphylaxis with necrosis of the glans penis: a case presentation. Hemodial Int. 2007;11(3):300–2. https://doi.org/10.1111/j.1542-4758.2007.00183.x.CrossRefPubMed

81.

Dastamani C, Kairi E, Arapoglou V, Vouza E, Karvouni E, Kondi-Pafiti A. Unusual presentation of Mönckeberg’s sclerosis in the thyroid vessels of three female patients. Int J Angiol. 2010;19(1):e45–7. https://doi.org/10.1055/s-0031-1278359.CrossRefPubMedPubMedCentral

82.

San Norberto EM, Revilla Á, Vaquero C. Mönckeberg’s disease of the lower limb. Vasc Endovasc Surg. 2021. https://doi.org/10.1177/1538574420987448.

83.

Chen NX, Moe SM. Pathophysiology of vascular calcification. Curr Osteoporos Rep. 2015;13(6):372–80. https://doi.org/10.1007/s11914-015-0293-9.CrossRefPubMed

84.

Buttgereit F, Matteson EL, Dejaco C. Polymyalgia rheumatica and giant cell arteritis. Jama. 2020;324(10):993–4. https://doi.org/10.1001/jama.2020.10155.CrossRefPubMed

85.

Winkler A, True D. Giant cell arteritis: 2018 Review. Mo Med. 2018;115(5):468–70.PubMedPubMedCentral

86.

Fayyaz B. Case report: giant cell arteritis in a patient with carotid atherosclerosis - a diagnostic dilemma. J Community Hosp Intern Med Perspect. 2018;8(3):134–7. https://doi.org/10.1080/20009666.2018.1458571.CrossRefPubMedPubMedCentral

87.

Kermani TA, Warrington KJ, Crowson CS, Ytterberg SR, Hunder GG, Gabriel SE, et al. Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis. Ann Rheum Dis. 2013;72(12):1989–94. https://doi.org/10.1136/annrheumdis-2012-202408.CrossRefPubMed

88.

Yamamoto Y, Ishikawa Y, Shimpo M, Matsumura M. Mönckeberg’s sclerosis. J Gen Fam Med. 2021;22(1):55–6. https://doi.org/10.1002/jgf2.380.CrossRefPubMed

89.

Buttgereit F, Dejaco C, Matteson EL, Dasgupta B. Polymyalgia rheumatica and giant cell arteritis: a systematic review. Jama. 2016;315(22):2442–58. https://doi.org/10.1001/jama.2016.5444.CrossRefPubMed

90.

Holle JU, Moosig F. Treatment of giant cell arteritis: what is in the pipeline? Z Rheumatol. 2020;79(6):516–22. https://doi.org/10.1007/s00393-020-00808-0.CrossRefPubMed

91.

Soriano A, Muratore F, Pipitone N, Boiardi L, Cimino L, Salvarani C. Visual loss and other cranial ischaemic complications in giant cell arteritis. Nat Rev Rheumatol. 2017;13(8):476–84. https://doi.org/10.1038/nrrheum.2017.98.CrossRefPubMed

92.

Kermani TA, Warrington KJ. Prognosis and monitoring of giant cell arteritis and associated complications. Expert Rev Clin Immunol. 2018;14(5):379–88. https://doi.org/10.1080/1744666x.2018.1467758.CrossRefPubMed

93.

Lyons HS, Quick V, Sinclair AJ, Nagaraju S, Mollan SP. A new era for giant cell arteritis. Eye (Lond). 2020;34(6):1013–26. https://doi.org/10.1038/s41433-019-0608-7.CrossRef

94.

Hwang ZA, Suh KJ, Chen D, Chan WP, Wu JS. Imaging features of soft-tissue calcifications and related diseases: a systematic approach. Korean J Radiol. 2018;19(6):1147–60. https://doi.org/10.3348/kjr.2018.19.6.1147.CrossRefPubMedPubMedCentral

95.

Macdonald DS, Zhang L, Gu Y. Calcification of the external carotid arteries and their branches. Dentomaxillofac Radiol. 2012;41(7):615–8. https://doi.org/10.1259/dmfr/88771381.CrossRefPubMedPubMedCentral

96.

Shabat S, Mann G, Stern A, Nyska M, Witz M. Popliteal artery rupture during total knee replacement in a patient with Mönckeberg’s sclerosis. Case report. J Knee Surg. 2004;17(2):117–9. https://doi.org/10.1055/s-0030-1248208.CrossRefPubMed

97.

Amillo Garayoa S, Leyes Vence M, Arriola Guenaga FJ. Transfer of the second toe to the hand in a patient with Monckeberg’s sclerosis. Scand J Plast Reconstr Surg Hand Surg. 1997;31(2):181–3. https://doi.org/10.3109/02844319709085487.CrossRef

98.

Weyand CM, Goronzy JJ. Medium- and large-vessel vasculitis. N Engl J Med. 2003;349(2):160–9. https://doi.org/10.1056/NEJMra022694.CrossRefPubMed

99.

Weyand CM, Goronzy JJ. Clinical practice. Giant-cell arteritis and polymyalgia rheumatica. N Engl J Med. 2014;371(1):50–7. https://doi.org/10.1056/NEJMcp1214825.CrossRefPubMedPubMedCentral

100.

Al-Mousawi AZ, Gurney SP, Lorenzi AR, Pohl U, Dayan M, Mollan SP. Reviewing the pathophysiology behind the advances in the management of giant cell arteritis. Ophthalmol Ther. 2019;8(2):177–93. https://doi.org/10.1007/s40123-019-0171-0.CrossRefPubMedPubMedCentral

101.

Mollan SP, Horsburgh J, Dasgupta B. Profile of tocilizumab and its potential in the treatment of giant cell arteritis. Eye Brain. 2018;10:1–11. https://doi.org/10.2147/eb.S127812.CrossRefPubMedPubMedCentral

102.

Al-Absi AI, Wall BM, Cooke CR. Medial arterial calcification mimicking temporal arteritis. Am J Kidney Dis. 2004;44(4):e73–8.CrossRef

Title: Monckeberg’s Medial Sclerosis as a Cause for Headache and Facial Pain
Authors: Davis C. Thomas
Prisly Thomas
Anilkumar Sivan
Priyanka Unnam
Ahana Ajayakumar
Sanjana Santhosh Kumar
Priyanka Kodaganallur Pitchumani
Mahnaz Fatahzadeh
Nida-e-Haque Mahmud
Publication date: 01-08-2021
Publisher: Springer US
Keywords: Giant Cell Arteritis
Giant Cell Arteritis
Headache and Facial Pain
Arterial Occlusive Disease
Headache
Published in: Current Pain and Headache Reports / Issue 8/2021
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-021-00965-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Monckeberg’s Medial Sclerosis as a Cause for Headache and Facial Pain

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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