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01-04-2009 | Case Report

Levofloxacin-induced delirium

Authors: Gleb Slobodin, Nizar Elias, Natalia Zaygraikin, Muhammad Sheikh-Ahmad, Sergiu Sabetay, Boaz Weller, Majed Odeh

Published in: Neurological Sciences | Issue 2/2009

Abstract

An 83-year-old man was admitted for right lower lobe pneumonia which did not improve after a 5-day outpatient treatment with amoxicillin/clavulinate and clarithromycin. An empiric treatment with levofloxacin was started with a significant improvement after 24 h of this treatment. On the third day of hospitalization, delirium developed, while the patient was afebrile and with normal blood oxygenation. Treatment with levofloxacin was stopped, and a complete resolution of the patient’s delirium was observed 2 days later. To the best of our knowledge, this is the third case of levofloxacin-induced delirium described in the medical literature.

Inouye SK (2006) Delirium in older persons. N Engl J Med 354:1157–1165PubMedCrossRef

Leentjens AF, van der Mast RC (2005) Delirium in elderly people. Curr Opin Psychiatry 18:325–330PubMedCrossRef

Alagiakrishnan K, Wiens CA (2004) An approach to drug induced delirium in the elderly. Postgrad Med J 80:388–393PubMedCrossRef

Brown TM (2000) Drug-induced delirium. Semin Clin Neuropsychiatry 5:113–124PubMed

Chow KM, Szeto CC, Hui AC, Wong TY, Li PK (2003) Retrospective review of neurotoxicity induced by cefepime and ceftazidime. Pharmacotherapy 23:369–373PubMedCrossRef

Vicente de Vera C, Garcia M, Pifarre Teixido R, Barbe F (2006) Delirium induced by clarithromycin in a patient with community-acquired pneumonia. Eur Respir J 28:671–672PubMedCrossRef

Mermelstein HT (1998) Clarithromycin-induced delirium in a general hospital. Psychosomatics 39:540–542PubMed

Hakko E, Mete B, Ozaras R, Tabak F, Ozturk R, Mert A (2005) Levofloxacin-induced delirium. Clin Neurol Neurosurg 107:158–159PubMedCrossRef

Kiangkitiwan B, Doppalapudi A, Fonder M, Solberg K, Bhner B (2008) Levofloxacin-induced delirium with psychotic features. Gen Hosp Psychiatry 30:381–383PubMedCrossRef

10.

Fennig S, Mauas L (1992) Ofloxacin-induced delirium. J Clin Psychiatry 53:137–138PubMed

11.

Jungst G, Mohr R (1988) Overview of postmarketing experience with ofloxacin in Germany. J Antimicrob Chemother 22:167–168PubMedCrossRef

12.

Jungst G, Mohr R (1987) Side effects of ofloxacin in clinical trails and in postmarketing surveillance. Drugs 34:S144–S149CrossRef

13.

Ball P, Mandell L, Niki Y (1999) Comparative tolerability of newer fluoroquinolone antibacterials. Drug Saf 21:410–421CrossRef

14.

Fernandez-Torre JL (2006) Levofloxacin-induced delirium: diagnostic considerations. Clin Neurol Neurosurg 108:614–618PubMedCrossRef

15.

Isaacson SH, Carr J, Rowan AJ (1993) Ciprofloxacin-induced complex partial status epilepticus manifesting as an acute confusional state. Neurology 43:1619–1620PubMed

Title: Levofloxacin-induced delirium
Authors: Gleb Slobodin
Nizar Elias
Natalia Zaygraikin
Muhammad Sheikh-Ahmad
Sergiu Sabetay
Boaz Weller
Majed Odeh
Publication date: 01-04-2009
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 2/2009
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-009-0027-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Levofloxacin-induced delirium

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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