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Journal of Neurology
Published in: Journal of Neurology 4/2016

01-04-2016 | Letter to the Editors

Levetiracetam associated acute hepatic failure requiring liver transplantation: case report

Authors: Vithyalakshmi Selvaraj, Jayakrishna S. Madabushi, Palanikumar Gunasekar, Sanjay P. Singh

Published in: Journal of Neurology | Issue 4/2016

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Excerpt

Dear Sirs, …
Literature
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Tan TC, de Boer BW, Mitchell A et al (2008) Levetiracetam as a possible cause of fulminant liver failure. Neurology 71(9):685–686CrossRefPubMed
2.
Sethi NK, Sethi PK, Torgovnick J, Arsura E, Cukierwar F (2013) Asymptomatic elevation of liver enzymes due to levetiracetam: a case report. Drug Metabol Drug Interact 28(2):123–124CrossRefPubMed
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Broli M, Provini F, Naldi I et al (2010) Unexpected gamma glutamyltransferase rise increase during levetiracetam monotherapy. Epileptic Disord 12(1):81–82PubMed
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Gutierrez-Grobe Y, Bahena-Gonzalez JA, Herrera-Gomar M, Mendoza-Diaz P, Garcia-Lopez S, Gonzalez-Chon O (2013) Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder. Case Rep Emerg Med 2013:634174PubMedPubMedCentral
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Azar NJ, Aune P (2014) Acute pancreatitis and elevated liver transaminases after rapid titration of oral levetiracetam. J Clin Neurosci 21(6):1053–1054CrossRefPubMed
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Brockmoller J, Thomsen T, Wittstock M, Coupez R, Lochs H, Roots I (2005) Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (child-pugh classes A, B, and C): characterization by dynamic liver function tests. Clin Pharmacol Ther 77(6):529–541CrossRefPubMed
Metadata
Title
Levetiracetam associated acute hepatic failure requiring liver transplantation: case report
Authors
Vithyalakshmi Selvaraj
Jayakrishna S. Madabushi
Palanikumar Gunasekar
Sanjay P. Singh
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 4/2016
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-015-8011-1

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