Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 3/2016

01-03-2016 | Letter to the Editor

Lethal 5-fluorouracil toxicity in a colorectal patient with severe dihydropyrimidine dehydrogenase (DPD) deficiency

Authors: Carole Dhelens, Agnès Bonadona, Fabienne Thomas, Claire Chapuis, Leila Potton, Sabrina Marsili, Pierrick Bedouch, Carole Schwebel

Published in: International Journal of Colorectal Disease | Issue 3/2016

Login to get access

Excerpt

Dear Editor: …
Literature
1.
Morel A, Boisdron-Celle M, Fey L et al (2006) Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther 5:2895–04CrossRefPubMed
2.
Amstutz U, Froehlich TK, Largiadèr CR (2011) Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity. Pharmacogenomics 12:1321–1336CrossRefPubMed
3.
Van Kuilenburg ABP (2004) Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 40:939–950CrossRefPubMed
4.
Caudle KE, Thorn CF, Klein TE et al (2013) Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther 94:640–645CrossRefPubMedPubMedCentral
Metadata
Title
Lethal 5-fluorouracil toxicity in a colorectal patient with severe dihydropyrimidine dehydrogenase (DPD) deficiency
Authors
Carole Dhelens
Agnès Bonadona
Fabienne Thomas
Claire Chapuis
Leila Potton
Sabrina Marsili
Pierrick Bedouch
Carole Schwebel
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 3/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-015-2191-0

Other articles of this Issue 3/2016

International Journal of Colorectal Disease 3/2016 Go to the issue

Original Article

Robot-assisted surgery for the radical treatment of deep infiltrating endometriosis with colorectal involvement: short- and mid-term surgical and functional outcomes

Letter to the Editor

Locally advanced anal canal carcinoma: is the addition of cetuximab the answer?

Original Article

Colorectal cancer in the elderly and the influence of lead time bias: better survival does not equate with improved life expectancy

Letter to the Editor

Intestinal spirochetosis: an unusual cause of IBD flare-up during anti-TNF therapy

Letter to the Editor

Unusual presentation of endometrioid adenocarcinoma arising in colonic endometriosis. A case report

Original Article

Ileostomy closure by colorectal surgeons results in less major morbidity: results from an institutional change in practice and awareness