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BMC Infectious Diseases

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Open Access 01-12-2023 | Leptospirosis | Case Report

Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report

Authors: Jianyu Ji, Wei Wang, Shulin Xiang, Xiutian Wei, Guangbao Pang, Huirong Shi, Jinda Dong, Jing Pang

Published in: BMC Infectious Diseases | Issue 1/2023

Abstract

Background

Leptospirosis is an infectious disease caused by pathogenic Leptospira spp., which could result in severe illnesses. Indirect contact with these pathogens is more common. Individuals could contract this disease through contact with contaminated water or during floods. In this case, we present the details of a 40-year-old male pig farmer who suffered from severe pulmonary hemorrhagic leptospirosis and multiple organ failure. The diagnosis of leptospirosis was confirmed through metagenomics next-generation sequencing (mNGS) while the patient received extracorporeal membrane oxygenation (ECMO) support, and antibiotic treatment was adjusted accordingly. The patient underwent comprehensive treatment and rehabilitation in the intensive care unit.

Conclusion

This case illustrates the importance of early diagnosis and treatment of leptospirosis. While obtaining the epidemiological history, second-generation metagenomics sequencing was utilized to confirm the etiology. The prompt initiation of ECMO therapy provided a crucial window of opportunity for addressing the underlying cause. This case report offers valuable insights for diagnosing patients with similar symptoms.

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Title: Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report
Authors: Jianyu Ji
Wei Wang
Shulin Xiang
Xiutian Wei
Guangbao Pang
Huirong Shi
Jinda Dong
Jing Pang
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Leptospirosis
ECMO
ECMO
Leptospira
Published in: BMC Infectious Diseases / Issue 1/2023
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-023-08793-w

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