Published in:
01-09-2012 | Review Article
Leptomeningeal carcinomatosis from ovarian cancer
Authors:
Eliza Miller, Irene Dy, Thomas Herzog
Published in:
Medical Oncology
|
Issue 3/2012
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Abstract
Ovarian cancer is the most common cause of mortality among women with gynecologic malignancies and the fifth leading cause of death in all women. It usually spreads locally; hematogenous dissemination is rare, most often involving the liver and lungs. Cerebral metastases are reported in less than 2% of cases and tend to localize to the parenchyma, usually in the cerebrum. Leptomeningeal involvement is exceptionally rare. We report a case of a woman with metastatic ovarian cancer who developed leptomeningeal carcinomatosis while receiving systemic chemotherapy. We also provide an extensive review of the existing literature on neoplastic meningitis from ovarian cancer.