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01-03-2013 | Case Report

Left-Ventricular Noncompaction in an Infant With Trisomy 21

Authors: Mandar B. Patil, Sunita M. Patil

Published in: Pediatric Cardiology | Issue 3/2013

Abstract

Left-ventricular noncompaction (LVNC) is a rare congenital cardiomyopathy of emerging importance. It is known to occur in association with genetic syndromes. We report here for the first time an infant with LVNC in association with trisomy 21.

Beken S, Cevik A, Turan O, Hirfanoglu IM, Unal S, Altuntas N et al (2011) A neonatal case of left ventricular noncompaction associated with trisomy 18. Genet Couns 22:161–164PubMed

Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R (1990) Isolated noncompaction of left ventricular myocardium: a study of eight cases. Circulation 82:507–513PubMedCrossRef

Elshershari H, Okutan V, Celiker A (2001) Isolated noncompaction of the ventricular myocardium. Cardiol Young 11:472–475PubMedCrossRef

Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T et al (1999) Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol 34:233–240PubMedCrossRef

Kenton AB, Sanchez X, Coveler KJ, Makar KA, Jimenez S, Ichida F et al (2004) Isolated left ventricular noncompaction is rarely caused by mutations in G 4.5, alpha-dystrobrevin and FK Binding Protein-12. Mol Genet Metab 82:162–166PubMedCrossRef

Laursen HB (1976) Congenital heart disease in Down’s syndrome. Br Heart J 38:32–38PubMedCrossRef

Oechslin E, Jenni R (2011) Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur Heart J 32:1446–1456PubMedCrossRef

Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R (2000) Long- term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 36:493–500PubMedCrossRef

Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J et al (2003) Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation 108:2672–2678PubMedCrossRef

10.

Tubman TR, Shields MD, Craig BG, Mulholland HC, Nevin NC (1991) Congenital heart disease in Down’s syndrome: two year prospective early screening study. Br Med J 302:1425–1427CrossRef

11.

Yukifumi M, Hirohiko S, Fukiko I, Mariko M (2011) Trisomy 13 in a 9-year-old girl with left ventricular noncompaction. Pediatr Cardiol 32:206–207PubMedCrossRef

12.

Zaragoza MV, Arbustini E, Narrula J (2007) Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology. Curr Opin Pediatr 19:619–627PubMedCrossRef

Title: Left-Ventricular Noncompaction in an Infant With Trisomy 21
Authors: Mandar B. Patil
Sunita M. Patil
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 3/2013
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-012-0330-8

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