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01-02-2011 | Research Article

Lectin–Gd-Loaded Chitosan Hydrogel Nanoparticles: A New Biospecific Contrast Agent for MRI

Authors: Irena Pashkunova-Martic, Christian Kremser, M. S. Galanski, Vladimir Arion, Paul Debbage, Werner Jaschke, Bernhard Keppler

Published in: Molecular Imaging and Biology | Issue 1/2011

Abstract

Purpose

Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin–gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations.

Procedures

Chitosan nanoparticles were prepared from 85% deacetylated chitin by glutaraldehyde cross-linking of an aqueous acetic acid dispersion of chitosan in a mixture of n-hexane using sodium bis(ethylhexyl)sulfosuccinate as a surfactant.

Results

Several crucial parameters, namely, the Gd and protein content of the nanoparticles, their size and dispersity were determined. Magnetic resonance measurements were carried out by intravenous perfusion of mono-disperse suspensions of the nanoparticles into mice.

Conclusions

Chitosan nanoparticles can be used as contrast agents in magnetic resonance imaging (MRI). They are excellent candidates for controlled delivery of bioactive compounds to molecular targets and as biospecific diagnostic tools in MRI.

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Title: Lectin–Gd-Loaded Chitosan Hydrogel Nanoparticles: A New Biospecific Contrast Agent for MRI
Authors: Irena Pashkunova-Martic
Christian Kremser
M. S. Galanski
Vladimir Arion
Paul Debbage
Werner Jaschke
Bernhard Keppler
Publication date: 01-02-2011
Publisher: Springer International Publishing
Published in: Molecular Imaging and Biology / Issue 1/2011
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-010-0309-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lectin–Gd-Loaded Chitosan Hydrogel Nanoparticles: A New Biospecific Contrast Agent for MRI

Abstract

Purpose

Procedures

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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