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Lasers in Medical Science
Published in: Lasers in Medical Science 2/2020

01-03-2020 | Laser | Review Article

Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity

Authors: Arezoo Rezaie Nezhad Zamani, Shirin Saberianpour, Mohammad Hossein Geranmayeh, Farhad Bani, Leila Haghighi, Reza Rahbarghazi

Published in: Lasers in Medical Science | Issue 2/2020

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Abstract

Differentiation potential of stem cells into various lineages makes these cells as promising sources to treat multiple diseases. In this regard, the use of different strategies and protocols to increase differentiation capacity is highly demanded. Low-level laser therapy, a relatively noninvasive technique, has the capacity to accelerate the healing of numerous injuries and a portion of restorative capacity could be correlated with the stem cell activation and differentiation. Several mechanisms have been diagnosed to participate in orientation of stem cells to functional mature cells. Among them, the status of DNA methylation orchestrates the maintenance of tissue-specific gene expression during the differentiation procedure. DNA methylation is a momentous event in embryogenesis and functional maturation. This review article highlighted the potency of laser irradiation (low-level intensities) in the differentiation of stem cells by modulation of methylation. The analysis of these modalities could help us to understand the underlying mechanisms participating in the therapeutic effects of photobiomodulation.
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Metadata
Title
Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity
Authors
Arezoo Rezaie Nezhad Zamani
Shirin Saberianpour
Mohammad Hossein Geranmayeh
Farhad Bani
Leila Haghighi
Reza Rahbarghazi
Publication date
01-03-2020
Publisher
Springer London
Keywords
Laser
Epigenetics
Published in
Lasers in Medical Science / Issue 2/2020
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-019-02873-7

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