Skip to main content
Top
Published in: Digestive Diseases and Sciences 5/2019

01-05-2019 | Laryngopharyngeal Reflux | Editorial

Laryngopharyngeal Reflux: Weak Acid and Weaker Correlations

Author: Steven R. DeMeester

Published in: Digestive Diseases and Sciences | Issue 5/2019

Login to get access

Excerpt

Cough, sore throat, hoarseness, globus sensation, neck pain, or a burning sensation in the tongue or mouth may be a consequence of laryngopharyngeal reflux (LRP), but these symptoms are non-specific and can be due to conditions other than LPR such as sinusitis, postnasal drip, allergies, or underlying laryngeal pathology [1, 2]. Further, as the name implies, LPR is presumed to be related to reflux of gastric contents up to the larynx and pharynx. The challenge with LPR has been to objectively confirm the presence of the disease in those that have it and likewise exclude it in those with symptoms attributed to alternate etiologies. Currently, although there is no “gold standard” test for the diagnosis, objective testing options include impedance–pH monitoring, particularly with catheters that extend above the upper esophageal sphincter, dual-probe pH testing, and Restech® pharyngeal pH monitoring. …
Literature
1.
go back to reference Patel D, Vaezi M. Normal esophageal physiology and laryngopharyngeal reflux. Otolaryngol Clin North Am. 2013;46:1023–1041.CrossRefPubMed Patel D, Vaezi M. Normal esophageal physiology and laryngopharyngeal reflux. Otolaryngol Clin North Am. 2013;46:1023–1041.CrossRefPubMed
2.
go back to reference Rafii B, Taliercio S, Achlatis S, Ruiz R, Amin MR, Branski RC. Incidence of underlying laryngeal pathology in patients initially diagnosed with laryngopharyngeal reflux. Laryngoscope. 2014;124:1420–1424.CrossRefPubMed Rafii B, Taliercio S, Achlatis S, Ruiz R, Amin MR, Branski RC. Incidence of underlying laryngeal pathology in patients initially diagnosed with laryngopharyngeal reflux. Laryngoscope. 2014;124:1420–1424.CrossRefPubMed
4.
go back to reference Ayazi S, Lipham JC, Hagen JA, et al. A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold. J Gastrointest Surg. 2009;13:1422–1429.CrossRefPubMed Ayazi S, Lipham JC, Hagen JA, et al. A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold. J Gastrointest Surg. 2009;13:1422–1429.CrossRefPubMed
5.
go back to reference Morice AH. Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux? Lung. 2008;186:103–106.CrossRef Morice AH. Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux? Lung. 2008;186:103–106.CrossRef
6.
go back to reference Friedman M, Hamilton C, Samuelson CG, et al. The value of routine pH monitoring in the diagnosis and treatment of laryngopharyngeal reflux. Otolaryngol Head Neck Surg. 2012;146:952–958.CrossRefPubMed Friedman M, Hamilton C, Samuelson CG, et al. The value of routine pH monitoring in the diagnosis and treatment of laryngopharyngeal reflux. Otolaryngol Head Neck Surg. 2012;146:952–958.CrossRefPubMed
7.
go back to reference Hemmink GJ, Bredenoord AJ, Weusten BL, Monkelbaan JF, Timmer R, Smout AJ. Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: “on” or “off” proton pump inhibitor? Am J Gastroenterol. 2008;103:2446–2453.CrossRefPubMed Hemmink GJ, Bredenoord AJ, Weusten BL, Monkelbaan JF, Timmer R, Smout AJ. Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: “on” or “off” proton pump inhibitor? Am J Gastroenterol. 2008;103:2446–2453.CrossRefPubMed
8.
go back to reference Tutuian R, Mainie I, Agrawal A, Adams D, Castell DO. Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest. 2006;130(2):386–391.CrossRefPubMed Tutuian R, Mainie I, Agrawal A, Adams D, Castell DO. Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest. 2006;130(2):386–391.CrossRefPubMed
9.
go back to reference Worrell SG, DeMeester SR, Greene CL, Oh DS, Hagen JA. Pharyngeal pH monitoring better predicts a successful outcome for extraesophageal reflux symptoms after antireflux surgery. Surg Endosc. 2013;27(11):4113–4118.CrossRefPubMed Worrell SG, DeMeester SR, Greene CL, Oh DS, Hagen JA. Pharyngeal pH monitoring better predicts a successful outcome for extraesophageal reflux symptoms after antireflux surgery. Surg Endosc. 2013;27(11):4113–4118.CrossRefPubMed
Metadata
Title
Laryngopharyngeal Reflux: Weak Acid and Weaker Correlations
Author
Steven R. DeMeester
Publication date
01-05-2019
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 5/2019
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-019-5465-5

Other articles of this Issue 5/2019

Digestive Diseases and Sciences 5/2019 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.