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European Archives of Oto-Rhino-Laryngology

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01-02-2020 | Laryngectomy | Head and Neck

Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis

Authors: Maohua Wang, Youfang Xun, Kaijian Wang, Ling Lu, Aimin Yu, Bing Guan, Chenjie Yu

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2020

Abstract

Objective

The purpose of this study was to systematically evaluate the risk factors of pharyngocutaneous fistula (PCF) after total laryngectomy.

Methods

We systematically searched Pubmed, Web of Science, Cochrane Library, and Embase databases and included the literature according to the inclusion and exclusion criteria.

Results

A total of 52 studies with 8605 patients were included in the meta-analysis. The total incidence of PCF was 21% (1808/8605). Meta-analysis results indicated that age (OR = 1.29, 95% CI 1.06–1.58, P = 0.01), smoking (OR = 1.62, 95% CI 1.27–2.07, P < 0.01), COPD (chronic obstructive pulmonary disease) (OR = 1.62, 95% CI 1.19–2.22, P < 0.01), CAD (coronary atherosclerotic heart disease) (OR = 1.82, 95% CI 1.36–2.45, P < 0.01), T-stage (OR = 0.81, 95% CI 0.67–0.98, P = 0.03), previous radiotherapy (OR = 2.41, 95% CI 2.00–2.90, P < 0.01), preoperative albumin (OR = 2.95, 95% CI 1.47–5.91, P < 0.01), preoperative hemoglobin (OR = 1.97, 95% CI 1.28–3.03, P < 0.01), tumor site (OR = 0.28, 95% CI 0.22–0.36, P < 0.01), and treatment method (OR = 1.85, 95% CI 1.44–2.38, P < 0.01) were risk factors associated with PCF.

Conclusions

In our study, age, smoking, COPD, CAD, T-stage, previous radiotherapy, preoperative albumin, preoperative hemoglobin, tumor site, and treatment method were risk factors of PCF.

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Title: Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis
Authors: Maohua Wang
Youfang Xun
Kaijian Wang
Ling Lu
Aimin Yu
Bing Guan
Chenjie Yu
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Laryngectomy
Radiotherapy
Laryngeal Cancer
Laryngeal Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05718-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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