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01-08-2015 | Editorial

Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?

Authors: Patricia K. Nguyen, MD, Joseph C. Wu, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 4/2015

Excerpt

Heart failure is a devastating disease with high morbidity and mortality. In 2013, approximately 5.1 million people suffered from chronic heart failure in the United States.1 About 50% of these individuals died within 5 years of their initial diagnosis.1 The most common cause of heart failure is coronary artery disease. Unfortunately, treatment options remain limited. Current medical therapy, including angiotensin-converting enzyme (ACE) inhibitors, aldosterone antagonists, and angiotensin and adrenergic receptor blockers, only slow disease progression. The chronic shortage of donor organs restricts the number of heart transplantations performed. …

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden EJ, et al. Heart disease and stroke statistics-2013 update: A report from the American Heart Association. Circulation 2013;127:e6-245.CrossRefPubMed

Houser SR, Margulies KB, Murphy AM, et al. Animal models of heart failure: A scientific statement from the American Heart Association. Circ Res 2012;111:131-50.CrossRefPubMed

Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, et al. Animal models of heart failure: A scientific statement from the American Heart Association. Circ Res 2012;111:131-50.CrossRefPubMed

Chen IY, Wu JC. Cardiovascular molecular imaging: Focus on clinical translation. Circulation 2011;123:425-43.PubMedCentralCrossRefPubMed

Nguyen PK, Lan F, Wang Y, Wu JC. Imaging: Guiding the clinical translation of cardiac stem cell therapy. Circ Re. 2011;109:962-79.PubMedCentralCrossRefPubMed

Pfeffer JM, Pfeffer MA, Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res 1985;57:84-95.CrossRefPubMed

Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, et al. The deltaC isoform of CMAKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res 2003;92:912-9.CrossRefPubMed

Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, et al. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med 2005;11:409-17.CrossRefPubMed

Christensen MD, Dun W, Boyden PA, Anderson ME, Mohler PJ, Hund TJ. Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis. PLoS Comput Biol 2009;5:e1000583.PubMedCentralCrossRefPubMed

10.

Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, et al. Inhibition of elevated Ca²⁺/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res 2010;107:1150-61.CrossRefPubMed

11.

Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, et al. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest 2003;111:869-76.PubMedCentralCrossRefPubMed

12.

Marian AJ. Beta-adrenergic receptors signaling and heart failure in mice, rabbits and humans. J Mol Cell Cardiol 2006;41:11-3.PubMedCentralCrossRefPubMed

13.

Locher MR, Razumova MV, Stelzer JE, Norman HS, Moss RL. Effects of low-level α-myosin heavy chain expression on contractile kinetics in porcine myocardium. Am J Physiol Heart Circ Physiol 2011;300:H869-78.PubMedCentralCrossRefPubMed

14.

Zhang J, Wilke N, Wang Y, Zhang Y, Wang C, Eijgelshoven MH, et al. Functional and bioenergetic consequences of postinfarction left ventricular remodeling in a new porcine model. Circulation 1996;94:1089-100.CrossRefPubMed

15.

Carlsson M, Wilson M, Martin AJ, Saeed M. Myocardial microinfarction after coronary microembolization in swine: MR imaging characterization. Radiology 2009;250:703-13.PubMedCentralCrossRefPubMed

16.

Koudstaal S, Jansen of Lorkeers S, Gho JM, van Hout GP, Jansen MS, Grundeman PF, et al. Myocardial infarction and functional outcome assessment in pigs. J Vis Exp 2014;86:e51269.

17.

McCall FC, Telukuntla KS, Karantalis V, Suncion VY, Heldman AW, Mushtag M, et al. Myocardial infarction and intramyocardial injection models in swine. Nat Protoc 2012;7:1479-96.PubMedCentralCrossRefPubMed

18.

Teramoto N, Koshino K, Yokoyama I, Miyagawa S, Zeniya T, Hirano Y, et al. Experimental pig model of old myocardial infarction with long survival leading to chronic left ventricular dysfunction and remodeling as evaluated by PET. J Nucl Med 2011;52:761-8.CrossRefPubMed

19.

Malik N, Farrell K, Withers S, Wright E, Holt C. A novel porcine model of early left ventricular dysfunction for translational research. Res Rep Clin Cardiol 2013;4:1-7.

20.

Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA 2006;296:1731-2.PubMed

21.

Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, et al. Nxy-059 for the treatment of acute ischemic stroke. N Engl J Med 2007;357:562-71.CrossRefPubMed

22.

Dirksen MT, Laarman GJ, Simoons ML, Duncker DJ. Reperfusion injury in humans: A review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc Res 2007;74:343-55.CrossRefPubMed

23.

van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O’Collins V, et al. Can animal models of disease reliably inform human studies? PLoS Med 2010;7:e1000245.PubMedCentralCrossRefPubMed

24.

Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007;357:1121-35.CrossRefPubMed

25.

Nguyen PK, Riegler J, Wu JC. Stem cell imaging: From bench to bedside. Cell Stem Cell 2014;14:431-44.PubMedCentralCrossRefPubMed

26.

Knaapen P, Germans T, Knuuti J, Paulus WJ, Dijkmans PA, Allaart CP, et al. Myocardial energetics and efficiency: Current status of the noninvasive approach. Circulation 2007;115:918-27.CrossRefPubMed

27.

Kim IS, Izawa H, Sobue T, Ishihara H, Somura E, Nishizawa T, et al. Prognostic value of mechanical efficiency in ambulatory patients with idiopathic dilated cardiomyopathy in sinus rhythm. J Am Coll Cardiol 2002;39:1264-8.CrossRefPubMed

28.

Eichhorn EJ, Heesch CM, Barnett JH, Alvarez LG, Fass SM, Grayburn PA, et al. Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study. J Am Coll Cardiol 1994;24:1310-20.CrossRefPubMed

29.

Beanlands RS, Nahmias C, Gordon E, deKemp R, Firnau G, Fallen E, et al. The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study. Circulation 2000;102:2070-5.CrossRefPubMed

30.

Gropler RJ. Noninvasive measurements of myocardial oxygen consumption-can we do better? J Am Coll Cardiol 2003;41:468-70.CrossRefPubMed

31.

McCommis KS, He X, Abendschein DR, Gupte PM, Gropler RJ, Zheng J. Cardiac 17o MRI: Toward direct quantification of myocardial oxygen consumption. Magn Reson Med 2010;63:1442-7.PubMedCentralCrossRefPubMed

32.

Yang Y, Foltz WD, Merchant N, Stainsby JA, Wright GA. Noninvasive quantitative measurement of myocardial and whole-body oxygen consumption using MRI: Initial results. Magn Reson Imaging 2009;27:147-54.CrossRefPubMed

33.

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72.CrossRefPubMed

34.

Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.CrossRefPubMed

35.

Burridge PW, Keller G, Gold JD, Wu JC. Production of de novo cardiomyocytes: Human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 2012;10:16-28.PubMedCentralCrossRefPubMed

36.

Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 2013;127:1677-91.CrossRefPubMed

37.

Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med 2012;4:130ra147.CrossRef

38.

Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013;12:101-13.PubMedCentralCrossRefPubMed

39.

Matsa E, Burridge PW, Wu JC. Human stem cells for modeling heart disease and for drug discovery. Sci Transl Med 2014;6:239ps236.CrossRef

Title: Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?
Authors: Patricia K. Nguyen, MD
Joseph C. Wu, MD, PhD
Publication date: 01-08-2015
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 4/2015
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-015-0078-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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