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Surgical Endoscopy
Published in: Surgical Endoscopy 8/2019

01-08-2019 | Laparoscopy | Review Article

Open versus laparoscopic hepatic resection for hepatocellular carcinoma: a systematic review and meta-analysis

Authors: Meng Xiangfei, Xu Yinzhe, Pan Yingwei, Lu Shichun, Duan Weidong

Published in: Surgical Endoscopy | Issue 8/2019

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Abstract

Background

Several studies have been conducted comparing laparoscopic liver resection (LLR) versus open liver resection (OLR) for hepatocellular carcinoma (HCC), however, the optimal therapeutic approach has not been established. Therefore, we conducted a systematic review and meta-analysis of studies comparing LLR versus OLR for HCC.

Methods

MEDLINE and Cochrane Central Register of Controlled Trials database were systematically searched for relevant studies.

Results

Fifty-one studies were identified including a total of 6812 patients (2786 patients underwent LLR and 4026 patients were subjected to OLR). Blood transfusion rate, hospital stay in days, 30-days mortality rate and morbidity were significantly lower in LLR comparing with OLR (odds ratio (OR) 0.45; 95% confidence interval (CI) 0.30–0.69; P = 0.001; I2 = 55.83%), (MD − 3.87; 95% CI − 4.86 to − 2.89; P = 0.001; I2 = 87.35%), (OR 0.32; 95% CI 0.16–0.66; P = 0.001; I2 = 0%), and (OR 0.42; 95% CI 0.34–0.52; P = 0.001; I2 = 39.64), respectively. There was no significant difference between LLR and OLR regarding the operative time in minutes, resection margin in centimeter and R0 resection (MD 18.29; 95% CI − 1.58 to 38.15; p = 0.07; I2 = 91.73%), (MD 0.04; 95% CI − 0.06 to 0.14; P = 0.41; I2 = 48.03%) and (OR 1.31; 95% CI 0.98–1.76; P = 0.07; I2 = 0%), respectively. The 1-year overall survival (1-OS) and 5-OS rates were significantly higher in LLR comparing with OLR (OR 1.45; 95% CI 1.06–1.99; P = 0.02; I2 = 25.59%) and (OR 1.36; 95% CI 1.07–1.72; P = 0.01; I2 = 14.88%), respectively.

Conclusion

LLR is superior to OLR regarding intraoperative blood loss, blood transfusion rate, hospital stay in days, 30-days mortality and morbidity, however, randomized controlled trials are needed to identify the superiority of either strategy.
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Metadata
Title
Open versus laparoscopic hepatic resection for hepatocellular carcinoma: a systematic review and meta-analysis
Authors
Meng Xiangfei
Xu Yinzhe
Pan Yingwei
Lu Shichun
Duan Weidong
Publication date
01-08-2019
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 8/2019
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-019-06781-3

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