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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 11/2011

01-11-2011 | Review

Laparoscopic versus conventional open surgery for immune function in patients with colorectal cancer

Authors: Chuanyuan Liu, Jungang Liu, Sen Zhang

Published in: International Journal of Colorectal Disease | Issue 11/2011

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Abstract

Objective

To systematically evaluate the immune function in patients with colorectal cancer after laparoscopic surgery (LS) and conventional open surgery (OS).

Methods

PUBMED, EMBASE, and the Cochrane library were searched and randomized controlled trials (RCTs) comparing the immunological difference between LS and OS were included. Two authors extracted data and assessed trial quality.

Results

Eleven studies including 695 patients were analysed. Immune-competent cells demonstrated no significant differences between LS and OS in six trials. Eight trials assessed various perioperative plasma cytokine concentrations with no significant differences in interleukin-6 (IL-6) and C-reactive protein (CRP) levels between LS and OS. However, meta-analysis showed higher T suppressor lymphocytes (CD8+) counts on postoperative days (POD) 1–3 and lower plasma levels of CRP on POD 0–1 in LS group compared with OS group.

Conclusion

Although LS groups displayed higher T suppressor lymphocyte (CD8+) counts on postoperative days (POD) 1–3 and lower plasma levels of CRP on POD 0–1, there is no sufficient evidence to support superior preservation of global immune function with LS compared to OS.
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Metadata
Title
Laparoscopic versus conventional open surgery for immune function in patients with colorectal cancer
Authors
Chuanyuan Liu
Jungang Liu
Sen Zhang
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 11/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-011-1281-x

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