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European Radiology
Published in: European Radiology 2/2010

Open Access 01-02-2010 | Molecular Imaging

Labelling of mammalian cells for visualisation by MRI

Authors: Monique R. Bernsen, Amber D. Moelker, Piotr A. Wielopolski, Sandra T. van Tiel, Gabriel P. Krestin

Published in: European Radiology | Issue 2/2010

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Abstract

Through labelling of cells with magnetic contrast agents it is possible to follow the fate of transplanted cells in vivo with magnetic resonance imaging (MRI) as has been demonstrated in animal studies as well as in a clinical setting. A large variety of labelling strategies are available that allow for prolonged and sensitive detection of the labelled cells with MRI. The various protocols each harbour specific advantages and disadvantages. In choosing a particular labelling strategy it is also important to ascertain that the labelling procedure does not negatively influence cell functionality, for which a large variety of assays are available. In order to overcome the challenges still faced in fully exploiting the benefits of in vivo cell tracking by MRI a good understanding and standardisation of the procedures and assays used will be crucial.
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Metadata
Title
Labelling of mammalian cells for visualisation by MRI
Authors
Monique R. Bernsen
Amber D. Moelker
Piotr A. Wielopolski
Sandra T. van Tiel
Gabriel P. Krestin
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 2/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-009-1540-1

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