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01-01-2018 | Note

Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

Authors: Ninh Khac Ban, Nguyen Thi Kim Thoa, Tran My Linh, Do Thi Trang, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Chau Van Minh, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim

Published in: Journal of Natural Medicines | Issue 1/2018

Abstract

Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC₅₀ values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively.

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Title: Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities
Authors: Ninh Khac Ban
Nguyen Thi Kim Thoa
Tran My Linh
Do Thi Trang
Phan Van Kiem
Nguyen Xuan Nhiem
Bui Huu Tai
Chau Van Minh
Jae-Hyoung Song
Hyun-Jeong Ko
Seung Hyun Kim
Publication date: 01-01-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1125-2

At a glance: The STEP trials

Springer Medicine

Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

Abstract

Graphical abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Graphical abstract

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