Skip to main content
Top
Published in: Journal of Natural Medicines 1/2018

01-01-2018 | Original Paper

Bioactive constituents from the whole plants of Leontopodium leontopodioides (Wild.) Beauv.

Authors: Qiu Chen, Jian Li, Jingya Ruan, Lu Qu, Hongyan Wei, Xiaoling Ma, Yi Zhang, Tao Wang

Published in: Journal of Natural Medicines | Issue 1/2018

Login to get access

Abstract

Five new compounds, leontoaerialosides A (1), B (2), C (3), D (4), and E (5) were obtained from the 70% EtOH extract of the whole plants of Leontopodium leontopodioides (Wild.) Beauv. Their structures were elucidated by chemical and spectroscopic methods. Moreover, compounds 4 and 5 showed significant effects on stimulating the hepatic glucose uptake in HepG2 cells.
Literature
1.
go back to reference Zhang Y, Ge D, Xue J, He W, Li C, Wang T (2011) Isolation and identification of flavonoids of whole plant of Leontopodium leontopodioides (Willd.) Beauv. Shenyang Yaokedaxue Xuebao 28:186–189, 205 Zhang Y, Ge D, Xue J, He W, Li C, Wang T (2011) Isolation and identification of flavonoids of whole plant of Leontopodium leontopodioides (Willd.) Beauv. Shenyang Yaokedaxue Xuebao 28:186–189, 205
2.
go back to reference Chen Q, Wang T, Ge D, He W, Wu C, Zhang Y (2012) Isolation and identification of flavonoids from Leontopodium leontopodioides (Willd.) Beauv. (II). Shenyang Yaokedaxue Xuebao 29:104–108 Chen Q, Wang T, Ge D, He W, Wu C, Zhang Y (2012) Isolation and identification of flavonoids from Leontopodium leontopodioides (Willd.) Beauv. (II). Shenyang Yaokedaxue Xuebao 29:104–108
3.
go back to reference Chen Q, Wang T, Wu C, Kaunda Joseph S, Han L, Zhang Y (2013) Isolation and identification of constituents from whole plant of Leontopodium leontopodioides (Willd.) Beauv. (III). Shenyang Yaokedaxue Xuebao 30:171–177 Chen Q, Wang T, Wu C, Kaunda Joseph S, Han L, Zhang Y (2013) Isolation and identification of constituents from whole plant of Leontopodium leontopodioides (Willd.) Beauv. (III). Shenyang Yaokedaxue Xuebao 30:171–177
4.
go back to reference Liu L, Kuang SJ, Liu CD, Wang SS, Guo Y (2014) Influence of Leontopodium on blood glucose and blood lipid metabolism of type 2 diabetic rats. Mod Med J China 16:11–13 Liu L, Kuang SJ, Liu CD, Wang SS, Guo Y (2014) Influence of Leontopodium on blood glucose and blood lipid metabolism of type 2 diabetic rats. Mod Med J China 16:11–13
5.
go back to reference Xiao YY, Xie HH, Zhao L, Gou P (2016) Acyl flavone and lignan glucosides from Leontopodium leontopodioides. Phytochem Lett 17:247–250CrossRef Xiao YY, Xie HH, Zhao L, Gou P (2016) Acyl flavone and lignan glucosides from Leontopodium leontopodioides. Phytochem Lett 17:247–250CrossRef
6.
go back to reference Zhang Y, Qu L, Liu L, Li X, Liu E, Han L, Fang S, Gao X, Wang T (2015) New maltol glycosides from Flos Sophorae. J Nat Med 69:249–254CrossRef Zhang Y, Qu L, Liu L, Li X, Liu E, Han L, Fang S, Gao X, Wang T (2015) New maltol glycosides from Flos Sophorae. J Nat Med 69:249–254CrossRef
7.
go back to reference Zhang Y, Chao L, Ruan J, Zheng C, Yu H, Qu L, Han L, Wang T (2016) Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb. Fitoterapia 115:165–172CrossRef Zhang Y, Chao L, Ruan J, Zheng C, Yu H, Qu L, Han L, Wang T (2016) Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb. Fitoterapia 115:165–172CrossRef
8.
go back to reference Liu Y, Zhang J, Li H (2003) Synthesis of 2-phenyl-1,3-propanediol dicarbamate. Huaxuegongcheng 31(70–73):78 Liu Y, Zhang J, Li H (2003) Synthesis of 2-phenyl-1,3-propanediol dicarbamate. Huaxuegongcheng 31(70–73):78
9.
go back to reference Morikawa T, Zhang Y, Makamura S (2007) Bioactive constituents from Chinese natural medicines. XXII. Absolute structure of new megastigmane glycoside, sedumosides E1, E2, F1, F2, and G from Sedum sarmentosum (Crassulaceae). Chem Pharm Bull 55:435–441CrossRef Morikawa T, Zhang Y, Makamura S (2007) Bioactive constituents from Chinese natural medicines. XXII. Absolute structure of new megastigmane glycoside, sedumosides E1, E2, F1, F2, and G from Sedum sarmentosum (Crassulaceae). Chem Pharm Bull 55:435–441CrossRef
10.
go back to reference Miyase T, Ueno A, Takizawa N, Kobayashi H, Karasawa H (1987) Studies on the glycosides of Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI I. Chem Pharm Bull 35:1109–1117CrossRef Miyase T, Ueno A, Takizawa N, Kobayashi H, Karasawa H (1987) Studies on the glycosides of Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI I. Chem Pharm Bull 35:1109–1117CrossRef
11.
go back to reference Wang L, Li F, Yang CY, Khan AA, Liu X, Wang MK (2014) Neolignans, lignans and glycoside from the fruits of Melia toosendan. Fitoterapia 99:92–98CrossRef Wang L, Li F, Yang CY, Khan AA, Liu X, Wang MK (2014) Neolignans, lignans and glycoside from the fruits of Melia toosendan. Fitoterapia 99:92–98CrossRef
12.
go back to reference Iida N, Inatomi Y, Murata H, Murata J, Lang FA, Tanaka T, Nakanishi T, Inada A (2010) New phenylpropanoid glycosides from Juniperus communis var. depressa. Chem Pharm Bull 58:742–746CrossRef Iida N, Inatomi Y, Murata H, Murata J, Lang FA, Tanaka T, Nakanishi T, Inada A (2010) New phenylpropanoid glycosides from Juniperus communis var. depressa. Chem Pharm Bull 58:742–746CrossRef
13.
go back to reference Huang XX, Zhou CC, Li LZ, Peng Y, Lou LL, Liu S, Li DM, Ikejima T, Song SJ (2013) Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida. Fitoterapia 91:217–223CrossRef Huang XX, Zhou CC, Li LZ, Peng Y, Lou LL, Liu S, Li DM, Ikejima T, Song SJ (2013) Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida. Fitoterapia 91:217–223CrossRef
14.
go back to reference Mohd Abdul Rashid MB, Toh TB, Silva A, Nurrul Abdullah L, Ho CM, Ho D, Chow EK (2015) Identification and optimization of combinatorial glucose metabolism inhibitors in hepatocellular carcinomas. J Lab Autom 20:423–437CrossRef Mohd Abdul Rashid MB, Toh TB, Silva A, Nurrul Abdullah L, Ho CM, Ho D, Chow EK (2015) Identification and optimization of combinatorial glucose metabolism inhibitors in hepatocellular carcinomas. J Lab Autom 20:423–437CrossRef
Metadata
Title
Bioactive constituents from the whole plants of Leontopodium leontopodioides (Wild.) Beauv.
Authors
Qiu Chen
Jian Li
Jingya Ruan
Lu Qu
Hongyan Wei
Xiaoling Ma
Yi Zhang
Tao Wang
Publication date
01-01-2018
Publisher
Springer Singapore
Published in
Journal of Natural Medicines / Issue 1/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-017-1132-3

Other articles of this Issue 1/2018

Journal of Natural Medicines 1/2018 Go to the issue