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Tumor Biology
Published in: Tumor Biology 1/2014

01-01-2014 | Research Article

Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma

Authors: Xionghui Mao, Susheng Miao, Hongjiang He, Suping Miao, Rong Pei, Xianguang Yang, Chen Xiu, Kaibin Song, Jian Zhang, Ji Sun, Shenshan Jia, Qiang Guan

Published in: Tumor Biology | Issue 1/2014

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Abstract

Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future.
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Metadata
Title
Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
Authors
Xionghui Mao
Susheng Miao
Hongjiang He
Suping Miao
Rong Pei
Xianguang Yang
Chen Xiu
Kaibin Song
Jian Zhang
Ji Sun
Shenshan Jia
Qiang Guan
Publication date
01-01-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 1/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1086-3

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