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Published in: Malaria Journal 1/2010

Open Access 01-12-2010 | Research

Knowledge and acceptability of the rectal treatment route in Laos and its application for pre-referral emergency malaria treatment

Authors: Southisouk Inthavilay, Thierry Franchard, Yang Meimei, Elizabeth A Ashley, Hubert Barennes

Published in: Malaria Journal | Issue 1/2010

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Abstract

Background

Rectal artesunate has been shown to reduce death and disability from severe malaria caused by delays in reaching facilities capable of providing appropriate treatment.
Acceptability of this mode of drug delivery in Laos is not known. In 2009 the acceptability of rectal treatments was evaluated among the general Lao population and Lao doctors in a national survey.

Methods

A cross sectional survey was performed of 985 households selected through a multi-stage random sampling process from 85 villages in 12/18 provinces and of 315 health staff randomly selected at each administrative level.

Results

Out of 985 families, 9% had used the rectal route to treat children (the main indication was seizures or constipation). The population considered it less effective than other routes. Other concerns raised included pain (28%), discomfort for children (40%) and the possibility of other side effects (20%). Of 300 health staff surveyed (nurses 44%, doctors 66%), only 51% had already used the rectal route with a suppository, mostly to treat fever (76%). Health staff working in provincial hospitals had more experience of using the rectal route than those in urban areas. The majority (92%) were keen to use the rectal route to treat malaria although oral and intramuscular routes were preferred and considered to be more efficacious.

Discussion and conclusion

Use of rectal treatments is uncommon in Laos and generally not considered to be very effective. This view is shared by the population and health care workers. More information and training are needed to convince the population and health staff of the efficacy and advantages of the rectal route for malaria treatment.
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Literature
1.
go back to reference Barennes H, Munjakazi J, Verdier F, Clavier F, Pussard E: An open randomized clinical study of intrarectal versus infused Quinimax for the treatment of childhood cerebral malaria in Niger. Trans R Soc Trop Med Hyg. 1998, 92: 437-440. 10.1016/S0035-9203(98)91083-5.CrossRefPubMed Barennes H, Munjakazi J, Verdier F, Clavier F, Pussard E: An open randomized clinical study of intrarectal versus infused Quinimax for the treatment of childhood cerebral malaria in Niger. Trans R Soc Trop Med Hyg. 1998, 92: 437-440. 10.1016/S0035-9203(98)91083-5.CrossRefPubMed
2.
go back to reference Barennes H, Balima-Koussoube T, Nagot N, Charpentier JC, Pussard E: Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial. BMJ. 2006, 332: 1055-1059. 10.1136/bmj.332.7549.1055.PubMedCentralCrossRefPubMed Barennes H, Balima-Koussoube T, Nagot N, Charpentier JC, Pussard E: Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial. BMJ. 2006, 332: 1055-1059. 10.1136/bmj.332.7549.1055.PubMedCentralCrossRefPubMed
3.
go back to reference Karunajeewa HA, Manning L, Mueller I, Ilett KF, Davis TM: Rectal administration of artemisinin derivatives for the treatment of malaria. JAMA. 2007, 297: 2381-90. 10.1001/jama.297.21.2381.CrossRefPubMed Karunajeewa HA, Manning L, Mueller I, Ilett KF, Davis TM: Rectal administration of artemisinin derivatives for the treatment of malaria. JAMA. 2007, 297: 2381-90. 10.1001/jama.297.21.2381.CrossRefPubMed
4.
go back to reference Gomes M, Faiz M, Gyapong J, Warsame M, Agbenyega T, Babiker A, Baiden F, Yunus EB, Binka F, Clerk C, Folb P, Hassan R, Hossain MA, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ: Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet. 2008, 373: 557-566. 10.1016/S0140-6736(08)61734-1.CrossRefPubMed Gomes M, Faiz M, Gyapong J, Warsame M, Agbenyega T, Babiker A, Baiden F, Yunus EB, Binka F, Clerk C, Folb P, Hassan R, Hossain MA, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ: Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet. 2008, 373: 557-566. 10.1016/S0140-6736(08)61734-1.CrossRefPubMed
5.
go back to reference Kaona FA, Tuba M: A qualitative study to identify community structures for management of severe malaria: a basis for introducing rectal artesunate in the under five years children in Nakonde District of Zambia. BMC Public Health. 2005, 5: 28-10.1186/1471-2458-5-28.PubMedCentralCrossRefPubMed Kaona FA, Tuba M: A qualitative study to identify community structures for management of severe malaria: a basis for introducing rectal artesunate in the under five years children in Nakonde District of Zambia. BMC Public Health. 2005, 5: 28-10.1186/1471-2458-5-28.PubMedCentralCrossRefPubMed
6.
go back to reference Thera MA, Keita F, Sissoko MS, Traore OB, Coulibaly D, Sacko M, Lameyre V, Ducret JP, Doumbo O: Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali. Malar J. 2007, 6: 68-10.1186/1475-2875-6-68.PubMedCentralCrossRefPubMed Thera MA, Keita F, Sissoko MS, Traore OB, Coulibaly D, Sacko M, Lameyre V, Ducret JP, Doumbo O: Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali. Malar J. 2007, 6: 68-10.1186/1475-2875-6-68.PubMedCentralCrossRefPubMed
7.
go back to reference Mayxay M: A Review: Malaria. Lao Medical Journal. 2010, 1: 3-13. Mayxay M: A Review: Malaria. Lao Medical Journal. 2010, 1: 3-13.
9.
go back to reference Simba DO, Warsame M, Kimbute O, Kakoko D, Petzold M, Tomson G, Premji Z, Gomes M: Factors influencing adherence to referral advice following pre-referral treatment with artesunate suppositories in children in rural Tanzania. Trop Med Int Health. 2009, 14: 775-83. 10.1111/j.1365-3156.2009.02299.x.CrossRefPubMed Simba DO, Warsame M, Kimbute O, Kakoko D, Petzold M, Tomson G, Premji Z, Gomes M: Factors influencing adherence to referral advice following pre-referral treatment with artesunate suppositories in children in rural Tanzania. Trop Med Int Health. 2009, 14: 775-83. 10.1111/j.1365-3156.2009.02299.x.CrossRefPubMed
10.
go back to reference Simba DO, Kakoko DC, Warsame M, Premji Z, Gomes MF, Tomson G, Johansson E: Understanding caretakers' dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate. Malar J. 2010, 9: 123-10.1186/1475-2875-9-123.PubMedCentralCrossRefPubMed Simba DO, Kakoko DC, Warsame M, Premji Z, Gomes MF, Tomson G, Johansson E: Understanding caretakers' dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate. Malar J. 2010, 9: 123-10.1186/1475-2875-9-123.PubMedCentralCrossRefPubMed
11.
go back to reference Jorgensen P, Nambanya S, Gopinath D, Hongvanthong B, Luangphengsouk K, Bell D, Phompida S, Phetsouvanh R: High heterogeneity in Plasmodium falciparum risk illustrates the need for detailed mapping to guide resource allocation: a new malaria risk map of the Lao People's Democratic Republic. Malar J. 2010, 9: 59-10.1186/1475-2875-9-59.PubMedCentralCrossRefPubMed Jorgensen P, Nambanya S, Gopinath D, Hongvanthong B, Luangphengsouk K, Bell D, Phompida S, Phetsouvanh R: High heterogeneity in Plasmodium falciparum risk illustrates the need for detailed mapping to guide resource allocation: a new malaria risk map of the Lao People's Democratic Republic. Malar J. 2010, 9: 59-10.1186/1475-2875-9-59.PubMedCentralCrossRefPubMed
12.
go back to reference Huygens P, Konate B, Traore A, Barennes H: [Traditional enema for newborns and infants in Bobo Dioulasso: health practice or socialisation]. Sante. 2002, 12: 357-62.PubMed Huygens P, Konate B, Traore A, Barennes H: [Traditional enema for newborns and infants in Bobo Dioulasso: health practice or socialisation]. Sante. 2002, 12: 357-62.PubMed
13.
go back to reference Mayxay M, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Newton PN: Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos). Trop Med Int Health. 2007, 12: 540-6. 10.1111/j.1365-3156.2007.01820.x.CrossRefPubMed Mayxay M, Pongvongsa T, Phompida S, Phetsouvanh R, White NJ, Newton PN: Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos). Trop Med Int Health. 2007, 12: 540-6. 10.1111/j.1365-3156.2007.01820.x.CrossRefPubMed
14.
go back to reference Barennes H, Srour LM, Pussard E: Is it too soon to eliminate quinine?. Lancet Infect Dis. 2010, 10: 141-2. 10.1016/S1473-3099(10)70009-8.CrossRefPubMed Barennes H, Srour LM, Pussard E: Is it too soon to eliminate quinine?. Lancet Infect Dis. 2010, 10: 141-2. 10.1016/S1473-3099(10)70009-8.CrossRefPubMed
Metadata
Title
Knowledge and acceptability of the rectal treatment route in Laos and its application for pre-referral emergency malaria treatment
Authors
Southisouk Inthavilay
Thierry Franchard
Yang Meimei
Elizabeth A Ashley
Hubert Barennes
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2010
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-9-342

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