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01-12-2021 | Knee Osteoarthritis | Review

Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint

Authors: Ahmad Almhdie-Imjabbar, Pawel Podsiadlo, Richard Ljuhar, Rachid Jennane, Khac-Lan Nguyen, Hechmi Toumi, Simo Saarakkala, Eric Lespessailles

Published in: Arthritis Research & Therapy | Issue 1/2021

Abstract

Background

Trabecular bone texture analysis (TBTA) has been identified as an imaging biomarker that provides information on trabecular bone changes due to knee osteoarthritis (KOA). Consequently, it is important to conduct a comprehensive review that would permit a better understanding of this unfamiliar image analysis technique in the area of KOA research.

We examined how TBTA, conducted on knee radiographs, is associated to (i) KOA incidence and progression, (ii) total knee arthroplasty, and (iii) KOA treatment responses. The primary aims of this study are twofold: to provide (i) a narrative review of the studies conducted on radiographic KOA using TBTA, and (ii) a viewpoint on future research priorities.

Method

Literature searches were performed in the PubMed electronic database. Studies published between June 1991 and March 2020 and related to traditional and fractal image analysis of trabecular bone texture (TBT) on knee radiographs were identified.

Results

The search resulted in 219 papers. After title and abstract scanning, 39 studies were found eligible and then classified in accordance to six criteria: cross-sectional evaluation of osteoarthritis and non-osteoarthritis knees, understanding of bone microarchitecture, prediction of KOA progression, KOA incidence, and total knee arthroplasty and association with treatment response. Numerous studies have reported the relevance of TBTA as a potential bioimaging marker in the prediction of KOA incidence and progression. However, only a few studies have focused on the association of TBTA with both OA treatment responses and the prediction of knee joint replacement.

Conclusion

Clear evidence of biological plausibility for TBTA in KOA is already established. The review confirms the consistent association between TBT and important KOA endpoints such as KOA radiographic incidence and progression. TBTA could provide markers for enrichment of clinical trials enhancing the screening of KOA progressors. Major advances were made towards a fully automated assessment of KOA.

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Title: Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint
Authors: Ahmad Almhdie-Imjabbar
Pawel Podsiadlo
Richard Ljuhar
Rachid Jennane
Khac-Lan Nguyen
Hechmi Toumi
Simo Saarakkala
Eric Lespessailles
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Knee Osteoarthritis
Osteoarthrosis
Osteoarthrosis
Knee Osteoarthritis
Published in: Arthritis Research & Therapy / Issue 1/2021
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/s13075-021-02594-9

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