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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2022

Open Access 01-12-2022 | Knee Osteoarthritis | Research

Effusion detected by ultrasonography and overweight may predict the risk of knee osteoarthritis in females with early knee osteoarthritis: a retrospective analysis of Iwaki cohort data

Authors: Kyota Ishibashi, Eiji Sasaki, Daisuke Chiba, Tetsushi Oyama, Seiya Ota, Hikaru Ishibashi, Yuji Yamamoto, Eiichi Tsuda, Kaori Sawada, Songee Jung, Yasuyuki Ishibashi

Published in: BMC Musculoskeletal Disorders | Issue 1/2022

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Abstract

Background

Knee osteoarthritis (OA) has enormous medical and socioeconomic burdens, which early diagnosis and intervention can reduce. We investigated the influence of knee effusion on the progression of knee OA in patients with early knee OA.

Methods

A total of 404 participants without radiographic knee OA were assessed from a 3-year longitudinal analysis. Participants were classified into non-OA and early knee OA groups. The effusion area (mm2) was quantified using ultrasonography. Receiver operating characteristic and logistic regression analyses were performed.

Results

At the 3-year follow-up, 114 of 349 knees (32%) had progressed from non-OA and 32 of 55 knees (58%) had progressed from early knee OA to radiographic knee OA. Logistic regression analysis showed that female sex (odds ratio [OR] 3.36, 95% confidence interval [CIs] 2.98–5.42), early knee OA (OR 2.02, 95% CI 1.08–3.75), body mass index (OR 1.11, 95% CI 1.02–1.19), and effusion area (OR 1.01, 95% CI 1.01–1.02) were significantly correlated with knee OA progression. Women who were overweight (body mass index ≥ 25 kg/m2) with more severe effusion had a higher risk of OA progression (area under the curve = 0.691, OR = 6.00) compared to those not overweight (area under the curve = 0.568, OR = 1.91).

Conclusion

Knee effusion may be an indicator of the progression of early-stage knee OA.
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Metadata
Title
Effusion detected by ultrasonography and overweight may predict the risk of knee osteoarthritis in females with early knee osteoarthritis: a retrospective analysis of Iwaki cohort data
Authors
Kyota Ishibashi
Eiji Sasaki
Daisuke Chiba
Tetsushi Oyama
Seiya Ota
Hikaru Ishibashi
Yuji Yamamoto
Eiichi Tsuda
Kaori Sawada
Songee Jung
Yasuyuki Ishibashi
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2022
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-022-05989-0

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