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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2024

Open Access 01-12-2024 | Knee Osteoarthritis | Research

Contralateral knee osteoarthritis is a risk factor for ipsilateral knee osteoarthritis progressing: a case control study

Authors: Zhengxu Dai, Tao Yang, Jun Liu

Published in: BMC Musculoskeletal Disorders | Issue 1/2024

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Abstract

Background

Knee osteoarthritis (KOA) is a highly disabling disease, and studying its progression is crucial. However, it is still unclear whether the progression of ipsilateral knee osteoarthritis is influenced by contralateral knee osteoarthritis.

Methods

Data were collected from the OAI database and divided into two study cohorts (right/left KOA cohort). Each cohort had a target knee (right/left knee) and was further divided into two groups (exposure/control group). The demographic data of both cohorts were balanced at baseline by propensity score matching (PSM), and the data included rating scale and radiographic and clinical data. After checking for balance in the matched variables, we then compared the differences between the two groups in each cohort. Our primary focus was on the minimum joint space width (mJSW) of the target knee, which was measured four years after baseline. The secondary outcome was the arthroplasty rate of the target knee within nine years.

Results

In this study, a total of 678 participants were enrolled and matched. After 1:1 PSM of the baseline demographic data, 98 participants in the right KOA cohort (RKOAC) were successfully matched, and 117 participants in the left KOA cohort (LKOAC) were successfully matched. Furthermore, the standardized mean difference (SMD) of the matched variables in both cohorts was less than 0.25. After analyzing the outcome metrics, we found that the target knee had a significantly lower mJSW in the fourth year after baseline and a significantly greater arthroplasty rate within nine years in the exposed group than in the control group. RKOAC: mJSW (exposure: 2.6(1.1 ~ 3.6) vs. control: 3.3(2.0 ~ 4.2), P < 0.05), arthroplasty rate (exposure: 14(14.3%) vs. control: 4(4.1%), P < 0.05); LKOAC: mJSW (exposure: 3.1(2 ~ 3.9) vs. control: 3.4(2.6 ~ 4.2), P < 0.05), arthroplasty rate (exposure: 16(13.7%) vs. control: 7(6%), P < 0.05).

Conclusions

Patients with knee osteoarthritis experienced greater progression of osteoarthritis when the contralateral knee was also affected.
Literature
1.
Disease G B D, Injury I. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the global burden of Disease Study 2015 [J]. Lancet. 2016;388(10053):1545–602.CrossRef
2.
Giorgino R, Albano D, Fusco S. Knee osteoarthritis: Epidemiology, Pathogenesis, and mesenchymal stem cells: what else is New? An update [J]. Int J Mol Sci, 2023, 24(7).
3.
Lee LS, Chan P K, Fung W C, et al. Imaging of knee osteoarthritis: a review of current evidence and clinical guidelines [J]. Musculoskelet Care. 2021;19(3):363–74.CrossRef
4.
Assari S, Bazargan M. The unequal effect of income on risk of Overweight/Obesity of whites and blacks with knee osteoarthritis: the Osteoarthritis Initiative [J]. J Racial Ethn Health Disparities. 2020;7(4):776–84.CrossRefPubMedPubMedCentral
5.
Alenazi A M, Alshehri M M Alothmans, et al. The Association of Diabetes with knee Pain Severity and distribution in people with knee osteoarthritis using data from the Osteoarthritis Initiative [J]. Sci Rep. 2020;10(1):3985.ADSCrossRefPubMed
6.
Sun X, Zhen X. Hu X, Osteoarthritis in the Middle-aged and Elderly in China: prevalence and influencing factors [J]. Int J Environ Res Public Health, 2019, 16(23).
7.
Kulkarni K, Karssiens T, Kumar V, et al. Obes Osteoarthr [J] Maturitas. 2016;89:22–8.
8.
Messier S P, Beavers D P, Queen K, et al. Effect of Diet and Exercise on knee Pain in patients with osteoarthritis and overweight or obesity: a randomized clinical trial [J]. JAMA. 2022;328(22):2242–51.CrossRefPubMed
9.
Ip H L, Nath D K, Sawleh SH, et al. Regenerative medicine for knee osteoarthritis - the efficacy and safety of intra-articular platelet-rich plasma and mesenchymal stem cells injections: a literature review [J]. Cureus. 2020;12(9):e10575.PubMed
10.
Callahan L F, Cleveland R J, Allen K D, et al. Racial/Ethnic, socioeconomic, and Geographic Disparities in the epidemiology of knee and hip osteoarthritis [J]. Rheum Dis Clin North Am. 2021;47(1):1–20.CrossRefPubMed
11.
Campbell TM. Knee flexion contracture Associated with a contracture and worse function of the contralateral knee: data from the Osteoarthritis Initiative [J]. Arch Phys Med Rehabil. 2020;101(4):624–32.CrossRefPubMed
12.
Metcalfe A J, Andersson M L, Goodfellow R, et al. Is knee osteoarthritis a symmetrical disease? Analysis of a 12 year prospective cohort study [J]. BMC Musculoskelet Disord. 2012;13:153.CrossRefPubMed
13.
Davis MA, Ettinger W H, Neuhaus JM, et al. The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee [J]. Am J Epidemiol. 1989;130(2):278–88.CrossRefPubMed
14.
15.
Migliorini F, Driessen A, Quack V, et al. Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: a bayesian network meta-analysis [J]. Arch Orthop Trauma Surg. 2021;141(9):1473–90.CrossRefPubMed
16.
Zeng, C, Lane N E, Hunter D J, et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative [J]. Osteoarthritis Cartilage. 2019;27(6):855–62.CrossRefPubMed
17.
Hangaard S, Boesen M, Bliddal H, et al. Do Ahlbцck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis? One-year follow-up data from the Osteoarthritis Initiative [J]. Skeletal Radiol. 2022;51(4):777–82.CrossRefPubMed
18.
Mitra R, Reiter JP. A comparison of two methods of estimating propensity scores after multiple imputation [J]. Stat Methods Med Res. 2016;25(1):188–204.MathSciNetCrossRefPubMed
19.
Austin PC, White I R Leeds, et al. Missing Data in Clinical Research: a tutorial on multiple imputation [J]. Can J Cardiol. 2021;37(9):1322–31.CrossRefPubMed
20.
Kane L T, Fang T, Galetta M S, et al. Propensity score matching: a statistical method [J]. Clin Spine Surg. 2020;33(3):120–2.CrossRefPubMed
21.
ZHAO Q Y, LUO J C, SU Y, et al. Propensity score matching with R: conventional methods and new features [J]. Ann Transl Med. 2021;9(9):812.CrossRefPubMed
22.
23.
Carballo C B, Nakagawa Y, Sekiya I, et al. Basic Science of articular cartilage [J]. Clin Sports Med. 2017;36(3):413–25.CrossRefPubMed
24.
WEI W. Articular cartilage and osteochondral tissue engineering techniques: recent advances and challenges [J]. Bioact Mater. 2021;6(12):4830–55.PubMedPubMedCentral
25.
Musumeci G, Aiello F C, Szychlinska M A, et al. Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression [J]. Int J Mol Sci. 2015;16(3):6093–112.CrossRefPubMedPubMedCentral
26.
Wirth W, Roemer F W Mascheks, et al. Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI) [J]. Osteoarthritis Cartilage. 2019;27(11):1663–8.CrossRefPubMedPubMedCentral
27.
Eckstein F, Roemer F W Mascheks, et al. Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative [J]. Osteoarthritis Cartilage. 2019;27(2):273–7.CrossRefPubMed
28.
Cotofana S, Benichou O, HITZL W, et al. Is loss in femorotibial cartilage thickness related to severity of contra-lateral radiographic knee osteoarthritis?--longitudinal data from the Osteoarthritis Initiative [J]. Osteoarthritis Cartilage. 2014;22(12):2059–66.CrossRefPubMed
29.
Davis JE, Ward R J, Mackay JW, et al. Effusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis [J]. Rheumatology (Oxford). 2019;58(3):418–26.CrossRefPubMed
30.
Wu R, Fu G, Li M, et al. Contralateral advanced radiographic knee osteoarthritis predicts radiographic progression and future arthroplasty in ipsilateral knee with early-stage osteoarthritis [J]. Clin Rheumatol. 2022;41(10):3151–7.CrossRefPubMed
31.
Bacon K, Lavalley M P, Jafarzadeh S R, et al. Does cartilage loss cause pain in osteoarthritis and if so, how much? [J]. Ann Rheum Dis. 2020;79(8):1105–10.CrossRefPubMed
32.
DЦЁrio M, Hunter D J, Collins J E, et al. Association of baseline and change in tibial and femoral cartilage thickness and development of widespread full-thickness cartilage loss in knee osteoarthritis - data from the Osteoarthritis Initiative [J]. Osteoarthritis Cartilage. 2020;28(6):811–8.CrossRef
33.
Deveza L A, Downie A, Tamez-peЦa J G, et al. Trajectories of femorotibial cartilage thickness among persons with or at risk of knee osteoarthritis: development of a prediction model to identify progressors [J]. Osteoarthritis Cartilage. 2019;27(2):257–65.CrossRefPubMed
34.
Everhart JS, Abouljoud M M, Flanigan DC. Role of full-thickness cartilage defects in knee osteoarthritis (OA) incidence and progression: data from the OA Initiative [J]. J Orthop Res. 2019;37(1):77–83.CrossRefPubMed
35.
Wijn S R W, Rovers M M, Van Tienen T G et al. Intra-articular corticosteroid injections increase the risk of requiring knee arthroplasty [J]. Bone Joint J, 2020, 102–B(5): 586–92.
36.
Guan B, Liu F, Haj-Mirzaian A, et al. Deep learning risk assessment models for predicting progression of radiographic medial joint space loss over a 48-MONTH follow-up period [J]. Osteoarthritis Cartilage. 2020;28(4):428–37.CrossRefPubMedPubMedCentral
37.
Pishgar F, Kwee R M, Haj-Mirzaian A, et al. Association between Race and Radiographic, Symptomatic, and clinical Hand Osteoarthritis: a propensity score-matched study using Osteoarthritis Initiative Data [J]. Arthritis Rheumatol. 2022;74(3):453–61.CrossRefPubMed
38.
Mills K, Hettinga B A, Pohl M B, et al. Between-limb kinematic asymmetry during gait in unilateral and bilateral mild to moderate knee osteoarthritis [J]. Arch Phys Med Rehabil. 2013;94(11):2241–7.CrossRefPubMed
39.
Gay C, Chabaud A, Guilley E, et al. Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review [J]. Ann Phys Rehabil Med. 2016;59(3):174–83.CrossRefPubMed
40.
Katsumi R, Mannen E M, Bajaj G, et al. The influence of knee osteoarthritis on spinopelvic alignment and global sagittal balance [J]. J Knee Surg. 2023;36(9):917–24.CrossRefPubMed
Metadata
Title
Contralateral knee osteoarthritis is a risk factor for ipsilateral knee osteoarthritis progressing: a case control study
Authors
Zhengxu Dai
Tao Yang
Jun Liu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2024
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-024-07292-6

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