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Clinical Rheumatology
Published in: Clinical Rheumatology 1/2006

01-02-2006 | Original Article

Klinefelter’s syndrome and juvenile chronic arthritis

Authors: Laura J. Mirkinson, Ronald Ceruti, Ildy M. Katona

Published in: Clinical Rheumatology | Issue 1/2006

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Excerpt

Klinefelter’s syndrome (KS) is the most common disorder of sexual differentiation in males and the most common disorder of sex chromosomes in humans. In KS, primary male hypogonadism is caused by developmental testicular defects due to the presence of two or more X-chromosomes. The classic karyotype for KS is 47XXY, but the mosaic form, 46XY/47XXY occurs in about 10% of cases. Other extreme variants such as 48XXYY, 48XXXY, and 49XXXXY also exist. It is estimated that the frequency of KS is about 1/500 at conception and 1/1000 at birth due to in utero fetal loss. …
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Metadata
Title
Klinefelter’s syndrome and juvenile chronic arthritis
Authors
Laura J. Mirkinson
Ronald Ceruti
Ildy M. Katona
Publication date
01-02-2006
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 1/2006
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-005-1142-5

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