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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 1-2/2009

01-06-2009

Kinesin motor proteins as targets for cancer therapy

Authors: Dennis Huszar, Maria-Elena Theoclitou, Jeffrey Skolnik, Ronald Herbst

Published in: Cancer and Metastasis Reviews | Issue 1-2/2009

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Abstract

The process of mitosis is a validated point of intervention in cancer therapy and a variety of anti-mitotic drugs are successfully being used in the clinic. To date, all approved antimitotics target the spindle microtubules, thus interfering with spindle dynamics, leading to mitotic arrest and apoptosis. While effective, these drugs are also associated with a variety of side effects, including neurotoxicity. In recent years, mitotic kinesins have attracted significant attention in the search for novel, alternative mitotic drug targets. Due to their specific function in mitosis, targeting these proteins creates an opportunity for the development of more selective antimitotics with an improved side effect profile. In addition, kinesin inhibitors may overcome resistance to microtubule targeting drugs. Drug discovery efforts in this area have initially focused on the plus-end directed kinesin spindle protein (KSP) and a variety of compounds are currently undergoing clinical testing.
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Metadata
Title
Kinesin motor proteins as targets for cancer therapy
Authors
Dennis Huszar
Maria-Elena Theoclitou
Jeffrey Skolnik
Ronald Herbst
Publication date
01-06-2009
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1-2/2009
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-009-9185-8

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