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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-06-2021 | Kidney Transplantation | Research Article

Validation of multiparametric MRI by histopathology after nephrectomy: a case study

Authors: Anneloes de Boer, Tobias T. Pieters, Anita A. Harteveld, Peter J. Blankestijn, Clemens Bos, Martijn Froeling, Roel Goldschmeding, Hans J. M. Hoogduin, Jaap A. Joles, Bart-Jeroen Petri, Marianne C. Verhaar, Tim Leiner, Tri Q. Nguyen, Arjan D. van Zuilen

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2021

Abstract

Objectives

Renal multiparametric MRI (mpMRI) is a promising tool to monitor renal allograft health to enable timely treatment of chronic allograft nephropathy. This study aims to validate mpMRI by whole-kidney histology following transplantectomy.

Materials and methods

A patient with kidney transplant failure underwent mpMRI prior to transplantectomy. The mpMRI included blood oxygenation level-dependent (BOLD) MRI, T₁ and T₂ mapping, diffusion-weighted imaging (DWI), 2D phase contrast (2DPC) and arterial spin labeling (ASL). Parenchymal mpMRI measures were compared to normative values obtained in 19 healthy controls. Differences were expressed in standard deviations (SD) of normative values. The mpMRI measures were compared qualitatively to histology.

Results

The mpMRI showed a heterogeneous parenchyma consistent with extensive interstitial hemorrhage on histology. A global increase in T₁ (+ 3.0 SD) and restricted diffusivity (− 3.6 SD) were consistent with inflammation and fibrosis. Decreased T₂ (− 1.8 SD) indicated fibrosis or hemorrhage. ASL showed diminished cortical perfusion (− 2.9 SD) with patent proximal arteries. 2DPC revealed a 69% decrease in renal perfusion. Histological evaluation showed a dense inflammatory infiltrate and fibrotic changes, consistent with mpMRI results. Most interlobular arteries were obliterated while proximal arteries were patent, consistent with ASL findings.

Discussion

mpMRI findings correlated well with histology both globally as well as locally.

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Title: Validation of multiparametric MRI by histopathology after nephrectomy: a case study
Authors: Anneloes de Boer
Tobias T. Pieters
Anita A. Harteveld
Peter J. Blankestijn
Clemens Bos
Martijn Froeling
Roel Goldschmeding
Hans J. M. Hoogduin
Jaap A. Joles
Bart-Jeroen Petri
Marianne C. Verhaar
Tim Leiner
Tri Q. Nguyen
Arjan D. van Zuilen
Publication date: 01-06-2021
Publisher: Springer International Publishing
Keywords: Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2021
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00887-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Validation of multiparametric MRI by histopathology after nephrectomy: a case study

Abstract

Objectives

Materials and methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Discussion

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