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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2021

Open Access 01-12-2021 | Kidney Cancer | Review

Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular

Authors: Weipu Mao, Keyi Wang, Zonglin Wu, Bin Xu, Ming Chen

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

Kidney cancer is a common urological tumour. Owing to its high prevalence and mortality rate, it is the third most malignant tumour of the urinary system, followed by prostate and bladder cancers. It exerts a high degree of malignancy, and most of the distant metastasis occurs at an early stage; it is insensitive to chemoradiotherapy and easily develops drug resistance. The current treatment for kidney cancer mainly includes surgery, interventional embolization and targeted therapy; however, the treatment efficacy is poor. In recent years, the role of exosomes as mediators of intercellular communication and information exchange in the tumour microenvironment in tumour pathogenesis has attracted much attention. Exosomes are rich in bioactive substances such as nucleic acids, proteins and lipids and are involved in angiogenesis, immune regulation, drug resistance, formation of pre-metastatic niche, invasion and metastasis. This article reviews the ongoing research and applications of exosomes for the diagnosis and treatment of kidney cancer.
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Metadata
Title
Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular
Authors
Weipu Mao
Keyi Wang
Zonglin Wu
Bin Xu
Ming Chen
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-02114-2

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