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Archives of Orthopaedic and Trauma Surgery

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01-02-2014 | Osteoporotic Fracture Management

Key outcomes are usually not reported in published fracture secondary prevention programs: results of a systematic review

Authors: Joanna E. M. Sale, Dorcas Beaton, Josh Posen, Victoria Elliot-Gibson, Earl Bogoch

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 2/2014

Abstract

Objective

A secondary analysis of a systematic review on interventions to improve osteoporosis (OP) investigation and treatment was conducted to examine reported key outcomes: (1) the cost of the intervention; (2) the proportion of patients taking OP medication beyond 6 months of the intervention; and (3) the proportion of patients who re-fractured.

Methods

Fifty-seven articles reporting on 54 studies (64 interventions) from 11 countries were included. Intervention studies to improve OP management were eligible if they were conducted in an orthopedic setting and included primary data on ≥20 patients presenting with a hip fracture or any fragility fracture. To compare outcome data across all interventions regardless of study design, an equated proportion (EP) using a denominator based on the intention-to-treat principle was derived. Whether a cost analysis had been conducted, the EP of patients who were taking medication beyond 6 months of the intervention, and the EP of patients who re-fractured during the study period were documented.

Results

Of the 54 studies, 2 reported a cost analysis and demonstrated that the interventions were at least cost-effective. The EP for medication use beyond 6 months of the intervention ranged from 17 to 56% for four studies. The EP for re-fracture ranged from 0 to 5% for four studies.

Conclusion

Most interventions did not report key outcomes. In addition, authors used varying time frames for re-fracture and medication use, making direct comparisons impossible. Authors should consider including intervention costs, medication use beyond 6 months of the intervention, and re-fracture data in future fracture secondary prevention programs.

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Title: Key outcomes are usually not reported in published fracture secondary prevention programs: results of a systematic review
Authors: Joanna E. M. Sale
Dorcas Beaton
Josh Posen
Victoria Elliot-Gibson
Earl Bogoch
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 2/2014
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-011-1442-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Key outcomes are usually not reported in published fracture secondary prevention programs: results of a systematic review

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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