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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 9/2006

01-09-2006 | Original Paper

Ketamine-Induced Gastroprotection During Endotoxemia: Role of Heme-Oxygenase-1

Authors: Kenneth S. Helmer, James W. Suliburk, David W. Mercer

Published in: Digestive Diseases and Sciences | Issue 9/2006

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Abstract

Inducible nitric oxide synthase contributes to lipopolysacharide-induced gastric injury. In contrast, heme-oxygenase-1 has anti-inflammatory effects and is protective against oxidative tissue injury. Ketamine attenuates injury from lipopolysacharide and is associated with changes in oxidative stress proteins, but its effects on the stomach remain to be fully elucidated. We hypothesized that ketamine would diminish gastric injury from lipopolysacharide via down-regulation of nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase, as well as up-regulation of heme-oxygenase-1. Ketamine up-regulated heme-oxygenase-1 and attenuated lipopolysacharide-induced changes in gastric nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase. Ketamine negated LPS-induced gastric injury from acidified ethanol, an effect reversed by tin protoporphorin IX. Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1.
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Metadata
Title
Ketamine-Induced Gastroprotection During Endotoxemia: Role of Heme-Oxygenase-1
Authors
Kenneth S. Helmer
James W. Suliburk
David W. Mercer
Publication date
01-09-2006
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 9/2006
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-005-9013-0

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