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International Ophthalmology

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01-07-2020 | Keratoplasty | Original Paper

A retrospective study comparing DALK and PKP in the treatment of necrotizing stromal keratitis

Authors: Hanhan Liu, Shuirong Liu, Hui Tao, Shuyu Hu, Zhihong Deng, Jia Tan

Published in: International Ophthalmology | Issue 7/2020

Abstract

Purpose

To compare the clinical outcomes of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) in the treatment of necrotizing stromal keratitis (NSK).

Methods

A retrospective study of NSK patients who underwent keratoplasty between January 2015 and December 2017 in the Third Xiangya Hospital was carried out. Data including preoperative and postoperative best corrected visual acuity (BCVA), intraocular pressure, graft survival rates, corneal endothelial cell density, corneal topography and thickness were reviewed and analyzed by SPSS 23.0 software.

Results

Fifty patients were involved. Twenty-five patients received DALK, and the other half received PKP. The average follow-up period was 10.28 ± 5.92 months. At the end of the follow-up period, there were no significant differences in postoperative BCVA, recurrence of virus, graft rejection or graft failure between the two groups. There were also no significant differences in average central corneal thickness postoperatively at 3 months. However, the average corneal endothelial cell density at 3 months was significantly higher in the DALK group (2121.12 ± 450.80 cell/mm² in the DALK group versus 1812.16 ± 340.38 cell/mm² in the PKP group, P = 0.009).

Conclusion

Both DALK and PKP could increase visual acuity and prevent the progression of NSK. There were no significant differences between DALK and PKP in postoperative BCVA, rate of rejection, graft failure or recurrence rate. DALK significantly reduced the loss of corneal endothelial cells.

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Title: A retrospective study comparing DALK and PKP in the treatment of necrotizing stromal keratitis
Authors: Hanhan Liu
Shuirong Liu
Hui Tao
Shuyu Hu
Zhihong Deng
Jia Tan
Publication date: 01-07-2020
Publisher: Springer Netherlands
Keyword: Keratoplasty
Published in: International Ophthalmology / Issue 7/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01339-y

At a glance: The STEP trials

Springer Medicine

A retrospective study comparing DALK and PKP in the treatment of necrotizing stromal keratitis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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