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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 12/2023

17-08-2023 | Juvenile Rheumatoid Arthritis | Editorial Commentary

Serum Calprotectin in Juvenile Idiopathic Arthritis: A Hope or Hype?

Author: Anju Gupta

Published in: Indian Journal of Pediatrics | Issue 12/2023

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Excerpt

Calprotectin (CALPR) is a family of calcium-binding S-100 leucocyte proteins with antimicrobial properties [1]. Human CALPR is a dimer of S100A8 and S100A9 proteins. It has antimicrobial and antifungal properties because of its ability to sequester zinc, manganese and iron. It controls intracellular pathways of innate immune cells to produce inflammation [1]. …
Literature
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Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE. Calprotectin: From biomarker to biological function. Gut. 2021;70:1978–88.CrossRefPubMed
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Berntzen HB, Fagerhol MK, Ostensen M, Mowinckel P, Høyeraal HM. The L1 protein as a new indicator of inflammatory activity in patients with juvenile rheumatoid arthritis. J Rheumatol. 1991;18:133–8.PubMed
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Frosch M, Strey A, Vogl T, et al. Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 2000;43:628–37.CrossRefPubMed
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zur Wiesch AS, Foell D, Frosch M, Vogl T, Sorg C, Roth J. Myeloid related proteins MRP8/MRP14 may predict disease flares in juvenile idiopathic arthritis. Clin Exp Rheumatol. 2004;22:368–73.
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Frosch M, Vogl T, Seeliger S, et al. Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum. 2003;48:2622–6.CrossRefPubMed
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La C, Lê PQ, Ferster A, et al. Serum calprotectin (S100A8/A9): A promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis. RMD Open. 2021;7:e001646.CrossRefPubMedPubMedCentral
Metadata
Title
Serum Calprotectin in Juvenile Idiopathic Arthritis: A Hope or Hype?
Author
Anju Gupta
Publication date
17-08-2023
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 12/2023
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-023-04803-6

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