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Open Access 01-12-2017 | Editorial

JTM advances in uncharted territories: diseases and disorders of unknown etiology

Author: Monica C. Panelli

Published in: Journal of Translational Medicine | Issue 1/2017

Abstract

We are delighted to announce a new section in the Journal of Translational Medicine, ‘Illnesses of Unknown Etiology’. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

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NIH. TRANS-NIH ME/CFS Working Group. 2017. https://www.nih.gov/research-training/medical-research-initiatives/mecfs. Accessed 11 Aug 2017.

Glassford JAG. The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front Physiol. 2017;8:88.CrossRefPubMedPubMedCentral

NIH. NIH office of desease prevention: advancing the research me-cfm. 2016. https://prevention.nih.gov/programs-events/pathways-to-prevention/workshops/me-cfs. Accessed 16 Aug 2017.

NIH. NIH Intramural Study on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. 2016. https://mecfs.ctss.nih.gov/. Accessed 11 Aug 2017.

ClinicalTrials.gov. 2017. https://clinicaltrials.gov/. Accessed 11 Aug 2017.

Scheibenbogen C, et al. The European ME/CFS biomarker landscape project: an initiative of the European network EUROMENE. J Transl Med. 2017;15(1):162.CrossRefPubMedPubMedCentral

Jason A, Zinn ML, Zinn MA. Myalgic encephalomyelitis: symptoms and biomarkers. Curr Neuropharmacol. 2015;13(5):701–34.CrossRefPubMed

10.

Lidbury BA, et al. Activin B is a novel biomarker for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) diagnosis: a cross sectional study. J Transl Med. 2017;15(1):60.CrossRefPubMedPubMedCentral

11.

Stringer EA, et al. Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in Chronic Fatigue Syndrome: evidence of inflammatory pathology. J Transl Med. 2013;11(1):93.CrossRefPubMedPubMedCentral

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Skowera A, et al. High levels of type 2 cytokine-producing cells in Chronic Fatigue Syndrome. Clin Exp Immunol. 2004;135(2):294–302.CrossRefPubMedPubMedCentral

13.

Morris G, et al. The emerging role of autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Mol Neurobiol. 2014;49(2):741–56.CrossRefPubMed

14.

Morris G, Anderson G, Maes M. Hypothalamic–pituitary–adrenal hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a consequence of activated immune-inflammatory and oxidative and nitrosative pathways. Mol Neurobiol. 2016. doi:10.1007/s12035-016-0170-2.

15.

Falkenberg VR, et al. Acute psychosocial stress-mediated changes in the expression and methylation of perforin in Chronic Fatigue Syndrome. Genet Epigenet. 2013;5:1–9.PubMedPubMedCentral

16.

Curriu M, et al. Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome. J Transl Med. 2013;11(1):68.CrossRefPubMedPubMedCentral

17.

Viel S, et al. TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal. 2016;9(415):ra19.CrossRefPubMed

18.

Hardcastle SL, et al. Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). BMC Immunol. 2015;16(1):35.CrossRefPubMedPubMedCentral

19.

Hardcastle S, et al. Analysis of the relationship between immune dysfunction and symptom severity in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clin Cell Immunol. 2014;5(190):2.

20.

Foundation A. Fibromyalgia diagnosis. 2017. http://www.arthritis.org/about-arthritis/types/fibromyalgia/diagnosing.php. Accessed 11 Aug 2017.

21.

NIAMS. Questions and answers about fibromyalgia. 2017. https://www.niams.nih.gov/Health_Info/Fibromyalgia/default.asp. Accessed 11 Aug 2017.

Title: JTM advances in uncharted territories: diseases and disorders of unknown etiology
Author: Monica C. Panelli
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Translational Medicine / Issue 1/2017
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-017-1293-6

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