Intensive Care Medicine OnlineFirst articles

21-05-2024 | Guidelines

European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluids

Administration of resuscitation fluids is common in the management of critically ill patients [ 1 ]. The European Society of Intensive Care Medicine (ESICM) convened a group of content and method experts to issue a clinical practice guideline (CPG) …

Authors:: Yaseen M. Arabi, Emilie Belley-Cote, Andrea Carsetti, Daniel De Backer, Katia Donadello, Nicole P. Juffermans, Naomi Hammond, Jon Henrik Laake, Dawei Liu, Kathryn Maitland, Antonio Messina, Morten Hylander Møller, Daniele Poole, Rob Mac Sweeney, Jean-Louis Vincent, Fernando G. Zampieri, Fayez AlShamsi, European Society of Intensive Care Medicine

Open Access 21-05-2024 | Narrative Review

Nutrition in the intensive care unit: from the acute phase to beyond

Recent randomized controlled trials (RCTs) have shown no benefit but dose-dependent harm by early full nutritional support in critically ill patients. Lack of benefit may be explained by anabolic resistance, suppression of cellular repair …

Authors:: Angelique M. E. de Man, Jan Gunst, Annika Reintam Blaser

21-05-2024 | Correspondence

The role of pleural pressure and airway closure during mechanical ventilation

Authors:: Jan van Egmond, Jan Mulier

21-05-2024 | Editorial

Setting the ventilator in acute brain injury

When selecting IMV settings, a reasonable first step is to set Vt between 4 and 8 ml kg −1 of predicted body weight (PBW) [ 3 ], while ensuring that plateau pressure (Pplat) is ≤ 30 cmH ₂O. Vt in this range is deemed safe in most patients with …

Authors:: Raphaël Cinotti, Shaurya Taran, Robert D. Stevens

21-05-2024 | Editorial

Winning hearts and minds: the impact of illness severity and pre-morbid mental health on wellbeing after acute myocardial infarction with cardiogenic shock

Authors:: Walter Schiffer, Nancy K. Sweitzer, Christian Jung

Open Access 21-05-2024 | Correspondence

Routine colonoscopy in patients with high risk of non-occlusive mesenteric ischemia

Authors:: Alexander Supady, Hannes Neeff, Tobias Wengenmayer, Dominik Bettinger

21-05-2024 | Correspondence

The choice of crystalloid type in the intensive care unit is likely more complex than expected: should doubt benefit the patient?

Authors:: Gildas Gueret, Sabine Lemoine, Pascale Le Maguet

16-05-2024 | Clindamycin | Editorial

Treating necrotizing skin and soft-tissue infections

Typical cases are usually readily identified on clinical grounds, leading to early emergency admission and source control. In contrast, underestimation of the burden of comorbidities, slow onset or atypical symptoms without sepsis, are common risk …

Authors:: Philippe Montravers, Anna Norrby-Teglund, Patricia Munoz

16-05-2024 | ECMO | Letter

Volatile sedation practices in patients with severe acute respiratory distress syndrome under VV-ECMO support

Authors:: Sara Alcántara Carmona, Ana del Saz, Sofía Contreras, Jordi Riera, Aaron Blandino, the Volatile Sedation on VV-ECMO Research Group

15-05-2024 | Systematic Review

Interventions for improving critical care in low- and middle-income countries: a systematic review

Quality improvement (QI) interventions aim to systematically change a predefined process or pathway of patient care, and often target timeliness, efficiency, effectiveness, equity, and safety of care delivery [ 1 ]. Intervention strategies …

Authors:: Duncan Wagstaff, Sumaiya Arfin, Alba Korver, Patrick Chappel, Aasiyah Rashan, Rashan Haniffa, Abi Beane

Open Access 15-05-2024 | Original

Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study

As the population ages, a greater number of persons are living with functional limitation and frailty [ 1 ]. Frailty is a state of increased vulnerability resulting from a decline in reserve across multiple physiological systems, increasing …

Authors:: John Muscedere, Sean M. Bagshaw, Michelle Kho, Sangeeta Mehta, Deborah J. Cook, J. Gordon Boyd, Stephanie Sibley, Han T. Wang, Patrick M. Archambault, Martin Albert, Oleksa G. Rewa, Ian Ball, Patrick A. Norman, Andrew G. Day, Miranda Hunt, Osama Loubani, Tina Mele, Aimee J. Sarti, Jason Shahin, the Canadian Critical Care Trials Group

15-05-2024 | Echocardiography | Editorial

Using echocardiography to predict fluid-responsiveness and manage the need for fluids

1 The right ventricle (RV) is severely dilated (the right ventricle is bigger than the left ventricle (LV)), with or without a paradoxical septal motion [ 7 ]. Giving more fluids could be deleterious even in the case of non-severe right ventricular …

Authors:: Antoine Vieillard-Baron, Florence Boissier, Michel Slama

15-05-2024 | Brain Death | Letter

Successful implementation of the Spanish model of organ donation in a Brazilian state

Authors:: Joel de Andrade, Beatriz Dominguez-Gil, Elisabeth Coll, Glauco Adrieno Westphal

Open Access 15-05-2024 | Cytostatic Therapy | Narrative Review

Management of hematological patients requiring emergency chemotherapy in the intensive care unit

Hematological malignancies may require rapid-onset treatment because of their short doubling time, notably observed in acute leukemias and specific high-grade lymphomas. Furthermore, in targeted onco-hematological scenarios, chemotherapy is deemed …

Authors:: Antoine Lafarge, Dara Chean, Livia Whiting, Raphaël Clere-Jehl, the Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie (Grrr-OH) Network, and the Clinical Research in Intensive Care, Sepsis (CRICS) Group

Open Access 13-05-2024 | Acute Respiratory Distress-Syndrome | Editorial

Finding the optimal tidal volume in acute respiratory distress syndrome

The ARDS Network study was the seminal study introducing the concept of protective mechanical ventilation. However, a fixed V _Tcut-off (6 ml/kg PBW) has been recently questioned [ 9 – 11 ]. New evidence suggests that it may be more advantageous to …

Authors:: Mariangela Pellegrini, Lorenzo Del Sorbo, V. Marco Ranieri

Open Access 13-05-2024 | Penicillins | Original

Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial

Penicillin allergy labels (patient reported penicillin allergies) are present in up to 15% of adult hospital patients [ 1 , 2 ] and in 6.8% of critically ill patients in the intensive care unit (ICU) [ 3 ]. The prevalence of penicillin allergy …

Authors:: Morgan T. Rose, Natasha E. Holmes, Glenn M. Eastwood, Sara Vogrin, Fiona James, Joseph F. De Luca, Rinaldo Bellomo, Stephen J. Warrillow, Michelle Phung, Sara L. Barnes, Brendan Murfin, Ben Rogers, Belinda Lambros, Brennan Collis, Trisha N. Peel, Monica A. Slavin, Jason A. Trubiano

13-05-2024 | Septicemia | Editorial

Empirical antimicrobials in the intensive care unit

Authors:: Liesbet De Bus, Kostoula Arvaniti, Fredrik Sjövall

13-05-2024 | Acute Kidney Injury | Editorial

When is the optimal time to stop continuous renal replacement therapy in children?

Authors:: Shaegan Irusen, Antoine Schneider, Michael Joannidis

13-05-2024 | Thrombocytopenia | Understanding the Disease

Ten tips on sepsis-induced thrombocytopenia

A platelet count is the number of platelets per volume, typically analysed by automated instruments. In cases of abnormal counts, counts are repeated manually. Reported platelet counts are strictly quantitative and qualitative platelet dysfunction …

Authors:: Marc Leone, Nathan D. Nielsen, Lene Russell

08-05-2024 | Antibiotic | Letter

Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients

Authors:: Saliha Ergezen, Tim M. J. Ewoldt, Mathieu van der Jagt, Birgit C. P. Koch, Henrik Endeman, the DOLPHIN Investigators

Keynote webinar | Spotlight on medication adherence

Springer Medicine