Low oxygen (hypoxia) is a hallmark of rapidly growing solid tumors. Hypoxia has been indicated in a number of disease states, including anemia, renal failure, and cardiovascular disease, in addition to its central role in carcinogenesis. The …
Authors:
Rhia M. Martin, Samantha Diaz, Martin Poncelet, Benoit Driesschaert, Eugene Barth, Mrignayani Kotecha, Boris Epel, Gareth R. Eaton, Joshua R. Biller
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is a principal cause of life-threatening illness in adults and children [ 1 – 3 ]. There is evidence that oxidative stress is critical in pathogenesis of …
Authors:
Hanan B. Elajaili, Lukas B. Woodcock, Tanden A. Hovey, George A. Rinard, Samuel DeGraw, Autumn Canny, Nathan M. Dee, Joseph P. Y. Kao, Eva S. Nozik, Sandra S. Eaton, Gareth R. Eaton
Low tissue oxygenation and hypoxic conditions, that develop during growth of solid tumors, favor the formation of an aggressive tumor phenotype, which has a negative impact on almost all anticancer therapies used to date [ 1 ]. Therefore …
Authors:
Gabriela Dziurman, Agnieszka Drzał, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
Tumor hypoxia is associated with worse prognosis, decreased local tumor control and more aggressive phenotypes; it also decreases radiation sensitivity by 3- to 5-fold [ 1 , 2 ]. Over the last 50+ years, researchers have attempted to ameliorate …
Authors:
Ashlyn G. Rickard, Yvonne M. Mowery, Alex Bassil, Douglas C. Rouse, Nerissa T. Williams, Theresa Charity, Rafaela Belloni, Brian Crouch, Nimmi Ramanujam, Daniel Stevenson, Rico Castillo, Stephanie Blocker, Boris Epel, Mrignayani Kotecha, Gregory M. Palmer
Cancer is a major public health problem worldwide and is the second leading cause of death in the USA [ 1 ]. According to government statistics, approximately 38.4% of men and women are diagnosed with cancer during their lifespans [ 2 ]. About …
Authors:
Boris Epel, Navin Viswakarma, Subramanian V. Sundramoorthy, Nitin J. Pawar, Mrignayani Kotecha
In recent decades, the tumor microenvironment (TME) has been recognized as a key factor in cancer progression and therapy [ 1 ]. TME includes both the physical components, such as extracellular matrix, and physiological molecular components such as …
Authors:
Timothy D. Eubank, Andrey A. Bobko, E. Hannah Hoblitzell, Marieta Gencheva, Benoit Driesschaert, Valery V. Khramtsov
Open Access
30-06-2023 | Melanoma | Review Article
The incidence of melanoma is continuously increasing over time. Melanoma is the most aggressive skin cancer, significantly reducing quality of life and survival rates of patients at advanced stages. Therefore, early diagnosis remains the key to …
Authors:
Mohammad Wehbi, Evelyne Harkemanne, Lionel Mignion, Nicolas Joudiou, Isabelle Tromme, Jean-François Baurain, Bernard Gallez
The most severe form of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), is a principal cause of life-threatening illness in both adults and children. Prior to 2020, more than 190,000 cases of ARDS were reported annually in the …
Authors:
Hanan B. Elajaili, Nathan M. Dee, Sergey I. Dikalov, Joseph P. Y. Kao, Eva S. Nozik
