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01-01-2021 | Joint Pain | Brief Report

IL-18: a suggested target for immunomodulation in chikungunya virus infection

Authors: Chintana Chirathaworn, Jira Chansaenroj, Pornsuri Pongsuchart, Yong Poovorawan

Published in: Archives of Virology | Issue 1/2021

Abstract

Chronic joint pain is the most common pathology found in chikungunya virus (CHIKV)-infected patients. Eight cytokines were compared in CHIKV patients with and without joint pain. IL-4 and IL-13 levels were significantly lower in patients with joint pain (p = 0.006 and p < 0.0001, respectively). IL-18 levels were higher in the group of patients with joint pain (p < 0.0001) and were significantly higher on days 3 and 4 after onset (p = 0.0012 and p = 0.003, respectively). Moreover, TNF-α levels were significantly higher in patients with joint pain on day 3 (p = 0.028). This study demonstrated that cytokines, particularly IL-18, may be candidates for immunomodulation.

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Title: IL-18: a suggested target for immunomodulation in chikungunya virus infection
Authors: Chintana Chirathaworn
Jira Chansaenroj
Pornsuri Pongsuchart
Yong Poovorawan
Publication date: 01-01-2021
Publisher: Springer Vienna
Keywords: Joint Pain
Cytokines
Published in: Archives of Virology / Issue 1/2021
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04849-3

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