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19-03-2024 | Joint Infection | Original Paper

Disability-adjusted life years from bone and joint infections associated with antimicrobial resistance: an insight from the 2019 Global Burden of Disease Study

Authors: Kai-Uwe Lewandrowski, Roberto Carlos Lyra da Silva, John C. Elfar, Abduljabbar Alhammoud, Isam Sami Moghamis, Bendenikt W. Burkhardt, Joachim M. Oertel, Stefan Landgraeber, Rossano Kepler Alvim Fiorelli, Paulo Sérgio Teixeira de Carvalho, Ivo Abraham, Jorge Felipe Ramírez León, Ernesto Martinez, Morgan P. Lorio

Published in: International Orthopaedics

Abstract

Purpose

Bone and joint infections, complicated by the burgeoning challenge of antimicrobial resistance (AMR), pose significant public health threats by amplifying the disease burden globally. We leveraged results from the 2019 Global Burden of Disease Study (GBD) to explore the impact of AMR attributed to bone and joint infections in terms of disability-adjusted life years (DALYs), elucidating the contemporary status and temporal trends.

Methods

Utilizing GBD 2019 data, we summarized the burden of bone and joint infections attributed to AMR across 195 countries and territories in the 30 years from 1990 to 2019. We review the epidemiology of AMR in terms of age-standardized rates, the estimated DALYs, comprising years of life lost (YLLs) and years lived with disability (YLDs), as well as associations between DALYs and socio-demographic indices.

Results

The GBD revealed that DALYs attributed to bone and joint infections associated with AMR have risen discernibly between 1990 and 2019 globally. Significant geographical disparities and a positive correlation with socio-demographic indicators were observed. Staphylococcus aureus infections, Group A Streptococcus, Group B Streptococcus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter-related bone and joint infections were associated with the highest DALYs because of a high proportion of antimicrobial resistance. Countries with limited access to healthcare, suboptimal sanitary conditions, and inconsistent antibiotic stewardship were markedly impacted.

Conclusions

The GBD underscores the escalating burden of bone and joint infections exacerbated by AMR, necessitating urgent, multi-faceted interventions. Strategies to mitigate the progression and impact of AMR should emphasize prudent antimicrobial usage and robust infection prevention and control measures, coupled with advancements in diagnostic and therapeutic modalities.

Longo UG, De Salvatore S, Bandini B, et al (2023) Debridement, antibiotics, and implant retention (DAIR) for the early prosthetic joint infection of total knee and hip arthroplasties: a systematic review. J ISAKOS S2059775423005588. https://doi.org/10.1016/j.jisako.2023.09.003

Luppi V, Regis D, Sandri A, Magnan B (2023) Diagnosis of periprosthetic hip infection: a clinical update. Acta Biomed 94:e2023095PubMed

Peng G, Liu Q, Guan Z et al (2023) Diagnostic accuracy of sonication fluid cultures from prosthetic components in periprosthetic joint infection: an updated diagnostic meta-analysis. J Orthop Surg Res 18:175. https://doi.org/10.1186/s13018-023-03662-3CrossRefPubMedPubMedCentral

Garvin KL, Kildow BJ, Hewlett AL et al (2023) The challenge of emerging resistant gram-positive pathogens in hip and knee periprosthetic joint infections. J Bone Joint Surg Am. https://doi.org/10.2106/JBJS.22.00792CrossRefPubMed

Masetla MA, Ntuli PN, Abraham V et al (2023) Antimicrobial stewardship for outpatients with chronic bone and joint infections in the orthopaedic clinic of an academic tertiary hospital South Africa. Antibiotics 12:1142. https://doi.org/10.3390/antibiotics12071142CrossRefPubMedPubMedCentral

Young BC, Dudareva M, Vicentine MP et al (2023) Microbial persistence, replacement and local antimicrobial therapy in recurrent bone and joint infection. Antibiotics (Basel) 12:708. https://doi.org/10.3390/antibiotics12040708CrossRefPubMed

Klug A, Gramlich Y, Rudert M et al (2021) The projected volume of primary and revision total knee arthroplasty will place an immense burden on future health care systems over the next 30 years. Knee Surg Sports Traumatol Arthrosc 29:3287–3298. https://doi.org/10.1007/s00167-020-06154-7CrossRefPubMed

Ferry T, Kolenda C, Briot T et al (2021) Past and future of phage therapy and phage-derived proteins in patients with bone and joint infection. Viruses 13:2414. https://doi.org/10.3390/v13122414CrossRefPubMedPubMedCentral

Badge H, Churches T, Xuan W et al (2022) Timing and duration of antibiotic prophylaxis is associated with the risk of infection after hip and knee arthroplasty. Bone Jt Open 3:252–260. https://doi.org/10.1302/2633-1462.33.BJO-2021-0181.R1CrossRefPubMedPubMedCentral

10.

Bourget-Murray J, Azad M, Gofton W et al (2023) Is the routine use of local antibiotics in the management of periprosthetic joint infections justified? Hip Int 33:4–16. https://doi.org/10.1177/11207000221139467CrossRefPubMed

11.

Lacasse M, Derolez S, Bonnet E et al (2023) 2022 SPILF - clinical practice guidelines for the diagnosis and treatment of disco-vertebral infection in adults. Infect Dis Now 53:104647. https://doi.org/10.1016/j.idnow.2023.01.007CrossRefPubMed

12.

Pérez-Prieto D, Totlis T, Madjarevic T et al (2023) ESSKA and EBJIS recommendations for the management of infections after anterior cruciate ligament reconstruction (ACL-R): prevention, surgical treatment and rehabilitation. Knee Surg Sports Traumatol Arthrosc 31:4204–4212. https://doi.org/10.1007/s00167-023-07463-3CrossRefPubMedPubMedCentral

13.

Stahl JP, Canouï E, Pavese P et al (2023) SPILF update on bacterial arthritis in adults and children. Infect Dis Now 53:104694. https://doi.org/10.1016/j.idnow.2023.104694CrossRefPubMed

14.

Choi E-J, Kim S-Y, Kim H-G et al (2017) Percutaneous endoscopic debridement and drainage with four different approach methods for the treatment of spinal infection. Pain Physician 20:E933–E940PubMed

15.

Perni S, Alotaibi HF, Yergeshov AA et al (2020) Long acting anti-infection constructs on titanium. J Control Release 326:91–105. https://doi.org/10.1016/j.jconrel.2020.06.013CrossRefPubMed

16.

Wang J, Wang L (2021) Novel therapeutic interventions towards improved management of septic arthritis. BMC Musculoskelet Disord 22:530. https://doi.org/10.1186/s12891-021-04383-6CrossRefPubMedPubMedCentral

17.

Barros J, Monteiro FJ, Ferraz MP (2022) Bioengineering approaches to fight against orthopedic biomaterials related-infections. IJMS 23:11658. https://doi.org/10.3390/ijms231911658CrossRefPubMedPubMedCentral

18.

Gan Y, Zhao G, Wang Z et al (2023) Bacterial membrane vesicles: physiological roles, infection immunology, and applications. Adv Sci (Weinh) 10:e2301357. https://doi.org/10.1002/advs.202301357CrossRefPubMed

19.

Hassoun-Kheir N, Guedes M, Ngo Nsoga M-T et al (2023) A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe. Clin Microbiol Infect S1198-743X(23):00419–6. https://doi.org/10.1016/j.cmi.2023.09.001CrossRef

20.

Palestro CJ (2023) Molecular imaging of periprosthetic joint infections. Semin Nucl Med 53:167–174. https://doi.org/10.1053/j.semnuclmed.2022.11.004CrossRefPubMed

21.

Loharkar S, Basu S (2023) PET-computed tomography in bone and joint infections. PET Clin 18:49–69. https://doi.org/10.1016/j.cpet.2022.08.002CrossRefPubMed

22.

Hugues B, Emsen B, Pina Vegas L et al (2023) PET/CT for osteoarticular septic grafts in endocarditis: a large monocentric cohort. Joint Bone Spine 90:105577. https://doi.org/10.1016/j.jbspin.2023.105577CrossRefPubMed

23.

Aguilera-Correa JJ, Salinas B, González-Arjona M et al (2023) Positron emission tomography-computed tomography and magnetic resonance imaging assessments in a mouse model of implant-related bone and joint Staphylococcus aureus infection. Microbiol Spectr 11:e0454022. https://doi.org/10.1128/spectrum.04540-22CrossRefPubMed

24.

Dobaria DG, Cohen HL (2023) Osteomyelitis imaging. StatPearls. StatPearls Publishing, Treasure Island (FL)

25.

Lindsay SE, Lindsay HG, Kallet J et al (2021) MnTE-2-PyP disrupts Staphylococcus aureus biofilms in a novel fracture model. J Orthop Res 39:2439–2445. https://doi.org/10.1002/jor.24967CrossRefPubMed

26.

Caldwell M, Hughes M, Wei F et al (2023) Promising applications of D-amino acids in periprosthetic joint infection. Bone Res 11:14. https://doi.org/10.1038/s41413-023-00254-zCrossRefPubMedPubMedCentral

27.

Qi X, Brothers KM, Ma D et al (2021) The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation. J Bone Jt Infect 6:241–253. https://doi.org/10.5194/jbji-6-241-2021CrossRefPubMedPubMedCentral

28.

Ma D, Mandell JB, Donegan NP et al (2019) The toxin-antitoxin MazEF drives Staphylococcus aureus biofilm formation, antibiotic tolerance, and chronic infection. mBio 10:e01658-19CrossRefPubMedPubMedCentral

29.

Vos T, Lim SS, Abbafati C et al (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9CrossRef

Title: Disability-adjusted life years from bone and joint infections associated with antimicrobial resistance: an insight from the 2019 Global Burden of Disease Study
Authors: Kai-Uwe Lewandrowski
Roberto Carlos Lyra da Silva
John C. Elfar
Abduljabbar Alhammoud
Isam Sami Moghamis
Bendenikt W. Burkhardt
Joachim M. Oertel
Stefan Landgraeber
Rossano Kepler Alvim Fiorelli
Paulo Sérgio Teixeira de Carvalho
Ivo Abraham
Jorge Felipe Ramírez León
Ernesto Martinez
Morgan P. Lorio
Publication date: 19-03-2024
Publisher: Springer Berlin Heidelberg
Keywords: Joint Infection
Streptococci
Escherichia Coli
Antibiotic
Pseudomonas Aeruginosa
Published in: International Orthopaedics
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-024-06143-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Disability-adjusted life years from bone and joint infections associated with antimicrobial resistance: an insight from the 2019 Global Burden of Disease Study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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