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Published in: BMC Geriatrics 1/2018

Open Access 01-12-2018 | Research article

Item distribution, internal consistency, and structural validity of the German version of the DEMQOL and DEMQOL–proxy

Authors: Christian G. G. Schwab, Martin Nikolaus Dichter, Martin Berwig

Published in: BMC Geriatrics | Issue 1/2018

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Abstract

Background

Accurate assessment of health-related quality of life as an endpoint in intervention studies is a major challenge in dementia research. The DEMQOL (29 items) and the proxy version (32 items), which is partly based on the DEMQOL, are internationally used instruments. To date, there is no information on the structural validity, item distribution, or internal consistency for the German language version of these questionnaires.

Methods

This psychometric study is based on a secondary data analysis of a sample of 201 outpatients with a mild form of Alzheimer’s disease (AD) and their informal caregivers. The informal caregivers who were interviewed were involved in the care of the person with AD several times per week. The analysis for the evaluation of the structural validity was performed using Mokken scale analysis. The internal consistency was calculated using the ρ of the Molenaar Sijtsma statistic and Cronbach’s α.

Results

For both versions, four subscales were identified: [A] “positive emotions”, [B] “negative emotions”, [C] “physical and cognitive functioning”, and [D] “daily activities and social relationships”. For both instruments, the internal consistency of all subscales was considered “good” (ρ = 0.71–0.88, α = 0.72–0.87).

Conclusions

The results are a first indication of good construct validity of the instruments used for the German setting. We recommend further investigations of the test-retest reliability and the inter-rater reliability of the proxy instrument.
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Literature
1.
go back to reference Alzheimer's Disease International (ADI). World Alzheimer Report 2015: The global impact of dementia. In London; 2015. Alzheimer's Disease International (ADI). World Alzheimer Report 2015: The global impact of dementia. In London; 2015.
2.
go back to reference American Psychiatric Association (ed.): DSM-5. Diagnostic and statistical manual of mental disorders, Fifth Edition edn. Washington/DC: American Psychiatric Publishing; 2013. American Psychiatric Association (ed.): DSM-5. Diagnostic and statistical manual of mental disorders, Fifth Edition edn. Washington/DC: American Psychiatric Publishing; 2013.
4.
go back to reference Mulhern B, Rowen D, Brazier J, Smith S, Romeo R, Tait R, Watchurst C, Chua KC, Loftus V, Young T et al: Development of DEMQOL-U and DEMQOL-PROXY-U: generation of preference-based indices from DEMQOL and DEMQOL-PROXY for use in economic evaluation. Health Technology Assessment 2013, 17(5):v-xv, 1–140.CrossRef Mulhern B, Rowen D, Brazier J, Smith S, Romeo R, Tait R, Watchurst C, Chua KC, Loftus V, Young T et al: Development of DEMQOL-U and DEMQOL-PROXY-U: generation of preference-based indices from DEMQOL and DEMQOL-PROXY for use in economic evaluation. Health Technology Assessment 2013, 17(5):v-xv, 1–140.CrossRef
5.
go back to reference Rowen D, Mulhern B, Banerjee S, Hout B, Young TA, Knapp M, Smith SC, Lamping DL, Brazier JE. Estimating preference-based single index measures for dementia using DEMQOL and DEMQOL-Proxy. Value Health. 2012;15. United States:346–56.CrossRef Rowen D, Mulhern B, Banerjee S, Hout B, Young TA, Knapp M, Smith SC, Lamping DL, Brazier JE. Estimating preference-based single index measures for dementia using DEMQOL and DEMQOL-Proxy. Value Health. 2012;15. United States:346–56.CrossRef
6.
go back to reference Rowen D, Mulhern B, Banerjee S, Tait R, Watchurst C, Smith SC, Young TA, Knapp M, Brazier JE. Comparison of general population, patient, and carer utility values for dementia health states. Medical Decision Making. 2015;35. United States:68–80.CrossRef Rowen D, Mulhern B, Banerjee S, Tait R, Watchurst C, Smith SC, Young TA, Knapp M, Brazier JE. Comparison of general population, patient, and carer utility values for dementia health states. Medical Decision Making. 2015;35. United States:68–80.CrossRef
7.
go back to reference Hays RD, Reeve BB: Measurement and modeling of health-related quality of life. In: Epidemiology and demography in public health. Edited by Killewo J, Heggenhougen HK, Quah SR. San Diego CA: Academic Press; 2010: 195–205. Hays RD, Reeve BB: Measurement and modeling of health-related quality of life. In: Epidemiology and demography in public health. Edited by Killewo J, Heggenhougen HK, Quah SR. San Diego CA: Academic Press; 2010: 195–205.
8.
go back to reference Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? PharmacoEconomics. 2016;34(7):645–9.CrossRef Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? PharmacoEconomics. 2016;34(7):645–9.CrossRef
9.
go back to reference Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. Jama. 1995;273(1):59–65.CrossRef Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. Jama. 1995;273(1):59–65.CrossRef
10.
go back to reference World Health Organization (WHO). Constitution of the World Health Organization. Basic documents of the Word Helath Organization. Geneva: World Health Organization; 2014. World Health Organization (WHO). Constitution of the World Health Organization. Basic documents of the Word Helath Organization. Geneva: World Health Organization; 2014.
11.
go back to reference Bakas T, McLennon SM, Carpenter JS, Buelow JM, Otte JL, Hanna KM, Ellett ML, Hadler KA, Welch JL. Systematic review of health-related quality of life models. Health Qual Life Outcomes. 2012;10:134.CrossRef Bakas T, McLennon SM, Carpenter JS, Buelow JM, Otte JL, Hanna KM, Ellett ML, Hadler KA, Welch JL. Systematic review of health-related quality of life models. Health Qual Life Outcomes. 2012;10:134.CrossRef
12.
go back to reference World Health Organization (WHO). International Classification of Functioning, disability, and Health: Children and Youth Version: ICF-CY. Geneva: World Health Organization; 2007. World Health Organization (WHO). International Classification of Functioning, disability, and Health: Children and Youth Version: ICF-CY. Geneva: World Health Organization; 2007.
13.
go back to reference Ferrans CE, Zerwic JJ, Wilbur JE, Larson JL. Conceptual model of health-related quality of life. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing. 2005;37(4):336–42.CrossRef Ferrans CE, Zerwic JJ, Wilbur JE, Larson JL. Conceptual model of health-related quality of life. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing. 2005;37(4):336–42.CrossRef
14.
go back to reference Smith SC, Murray J, Banerjee S, Foley B, Cook JC, Lamping DL, Prince M, Harwood RH, Levin E, Mann A. What constitutes health-related quality of life in dementia? Development of a conceptual framework for people with dementia and their carers. International journal of geriatric psychiatry. 2005;20(9):889–95.CrossRef Smith SC, Murray J, Banerjee S, Foley B, Cook JC, Lamping DL, Prince M, Harwood RH, Levin E, Mann A. What constitutes health-related quality of life in dementia? Development of a conceptual framework for people with dementia and their carers. International journal of geriatric psychiatry. 2005;20(9):889–95.CrossRef
15.
go back to reference Smith SC, Lamping DL, Banerjee S, Harwood R, Foley B, Smith P, Cook JC, Murray J, Prince M, Levin E, et al. Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology. Health Technol Assess. 2005;9(10):1–93 iii-iv.CrossRef Smith SC, Lamping DL, Banerjee S, Harwood R, Foley B, Smith P, Cook JC, Murray J, Prince M, Levin E, et al. Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology. Health Technol Assess. 2005;9(10):1–93 iii-iv.CrossRef
16.
go back to reference Berwig M, Leicht H, Gertz HJ. Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease - further evidence for the impact of anosognosia and global cognitive impairment. The journal of nutrition health and aging. 2009;13(3):226–30.CrossRef Berwig M, Leicht H, Gertz HJ. Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease - further evidence for the impact of anosognosia and global cognitive impairment. The journal of nutrition health and aging. 2009;13(3):226–30.CrossRef
17.
go back to reference Dichter MN, Schwab CGG, Meyer G, Bartholomeyczik S, Halek M. Linguistic validation and reliability properties are weak investigated of most dementia-specific quality of life measurements - a systematic review. J Clin Epidemiol. 2016;70:233–45.CrossRef Dichter MN, Schwab CGG, Meyer G, Bartholomeyczik S, Halek M. Linguistic validation and reliability properties are weak investigated of most dementia-specific quality of life measurements - a systematic review. J Clin Epidemiol. 2016;70:233–45.CrossRef
18.
go back to reference Lucas-Carrasco R, Lamping DL, Banerjee S, Rejas J, Smith SC, Gomez-Benito J. Validation of the Spanish version of the DEMQOL system. International psychogeriatrics / IPA. 2010;22(4):589–97.CrossRef Lucas-Carrasco R, Lamping DL, Banerjee S, Rejas J, Smith SC, Gomez-Benito J. Validation of the Spanish version of the DEMQOL system. International psychogeriatrics / IPA. 2010;22(4):589–97.CrossRef
19.
go back to reference Chua KC, Brown A, Little R, Matthews D, Morton L, Loftus V, Watchurst C, Tait R, Romeo R, Banerjee S. Quality-of-life assessment in dementia: the use of DEMQOL and DEMQOL-proxy total scores. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2016;25(12):3107–18.CrossRef Chua KC, Brown A, Little R, Matthews D, Morton L, Loftus V, Watchurst C, Tait R, Romeo R, Banerjee S. Quality-of-life assessment in dementia: the use of DEMQOL and DEMQOL-proxy total scores. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2016;25(12):3107–18.CrossRef
20.
go back to reference Hendriks AAJ, Smith SC, Chrysanthaki T, Cano SJ, Black N. DEMQOL and DEMQOL-proxy: a Rasch analysis. Health Qual Life Outcomes. 2017;15(1):164.CrossRef Hendriks AAJ, Smith SC, Chrysanthaki T, Cano SJ, Black N. DEMQOL and DEMQOL-proxy: a Rasch analysis. Health Qual Life Outcomes. 2017;15(1):164.CrossRef
21.
go back to reference Kurz A, Thone-Otto A, Cramer B, Egert S, Frolich L, Gertz HJ, Kehl V, Wagenpfeil S, Werheid K. CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial. Alzheimer Dis Assoc Disord. 2012;26(3):246–53.CrossRef Kurz A, Thone-Otto A, Cramer B, Egert S, Frolich L, Gertz HJ, Kehl V, Wagenpfeil S, Werheid K. CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial. Alzheimer Dis Assoc Disord. 2012;26(3):246–53.CrossRef
22.
go back to reference Swart E, Gothe H, Geyer S, Jaunzeme J, Maier B, Grobe TG, Ihle P, et al. [Good Practice of Secondary Data Analysis (GPS): Guidelines and Recommendations] Gute Praxis Sekundärdatenanalyse (GPS): Leitlinien und Empfehlungen. Gesundheitswesen. 2015;77(02):120–6.CrossRef Swart E, Gothe H, Geyer S, Jaunzeme J, Maier B, Grobe TG, Ihle P, et al. [Good Practice of Secondary Data Analysis (GPS): Guidelines and Recommendations] Gute Praxis Sekundärdatenanalyse (GPS): Leitlinien und Empfehlungen. Gesundheitswesen. 2015;77(02):120–6.CrossRef
23.
go back to reference Kessler J, Markowitsch HJ, Denzler PE. [Mini-Mental State Examination (MMSE) - German version] Mini-Mental-Status-Test (MMSE) - Deutsche Fassung. Beltz: Weinheim; 1990. Kessler J, Markowitsch HJ, Denzler PE. [Mini-Mental State Examination (MMSE) - German version] Mini-Mental-Status-Test (MMSE) - Deutsche Fassung. Beltz: Weinheim; 1990.
24.
go back to reference Hindmarch I, Lehfeld H, de Jongh P, Erzigkeit H. The Bayer activities of daily living scale (B-ADL). Dement Geriatr Cogn Disord. 1998;9(suppl 2):20–6.CrossRef Hindmarch I, Lehfeld H, de Jongh P, Erzigkeit H. The Bayer activities of daily living scale (B-ADL). Dement Geriatr Cogn Disord. 1998;9(suppl 2):20–6.CrossRef
25.
go back to reference Yesavage JA. Geriatric depression scale. Psychopharmacol Bull. 1988;24(4):709–11.PubMed Yesavage JA. Geriatric depression scale. Psychopharmacol Bull. 1988;24(4):709–11.PubMed
26.
go back to reference Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(5 Suppl 6):10–6.CrossRef Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(5 Suppl 6):10–6.CrossRef
27.
go back to reference Hautzinger M, Bailer M, Worall H, Keller F: [Beck-depression-inventory (BDI): editing of the German version - test manual] Beck-depressions-Inventar (BDI): Bearbeitung der deutschen Ausgabe - Testhandbuch, 2. Auflage edn. Bern: Hans Huber; 1994. Hautzinger M, Bailer M, Worall H, Keller F: [Beck-depression-inventory (BDI): editing of the German version - test manual] Beck-depressions-Inventar (BDI): Bearbeitung der deutschen Ausgabe - Testhandbuch, 2. Auflage edn. Bern: Hans Huber; 1994.
28.
go back to reference Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. The Gerontologist. 1980;20(6):649–55.CrossRef Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. The Gerontologist. 1980;20(6):649–55.CrossRef
29.
go back to reference Stochl J, Jones PB, Croudace TJ. Mokken scale analysis of mental health and well-being questionnaire item responses: a non-parametric IRT method in empirical research for applied health researchers. BMC Med Res Methodol. 2012;12:74.CrossRef Stochl J, Jones PB, Croudace TJ. Mokken scale analysis of mental health and well-being questionnaire item responses: a non-parametric IRT method in empirical research for applied health researchers. BMC Med Res Methodol. 2012;12:74.CrossRef
30.
go back to reference Watson R, van der Ark LA, Lin LC, Fieo R, Deary IJ, Meijer RR. Item response theory: how Mokken scaling can be used in clinical practice. J Clin Nurs. 2012;21(19–20):2736–46.CrossRef Watson R, van der Ark LA, Lin LC, Fieo R, Deary IJ, Meijer RR. Item response theory: how Mokken scaling can be used in clinical practice. J Clin Nurs. 2012;21(19–20):2736–46.CrossRef
31.
go back to reference Dichter MN, Dortmann O, Halek M, Meyer G, Holle D, Nordheim J, Bartholomeyczik S. Scalability and internal consistency of the German version of the dementia-specific quality of life instrument QUALIDEM in nursing homes -- a secondary data analysis. Health Qual Life Outcomes. 2013;11(1):91.CrossRef Dichter MN, Dortmann O, Halek M, Meyer G, Holle D, Nordheim J, Bartholomeyczik S. Scalability and internal consistency of the German version of the dementia-specific quality of life instrument QUALIDEM in nursing homes -- a secondary data analysis. Health Qual Life Outcomes. 2013;11(1):91.CrossRef
32.
go back to reference Bouman AI, Ettema TP, Wetzels RB, van Beek AP, de Lange J, Droes RM. Evaluation of Qualidem: a dementia-specific quality of life instrument for persons with dementia in residential settings; scalability and reliability of subscales in four Dutch field surveys. International journal of geriatric psychiatry. 2011;26(7):711–22.CrossRef Bouman AI, Ettema TP, Wetzels RB, van Beek AP, de Lange J, Droes RM. Evaluation of Qualidem: a dementia-specific quality of life instrument for persons with dementia in residential settings; scalability and reliability of subscales in four Dutch field surveys. International journal of geriatric psychiatry. 2011;26(7):711–22.CrossRef
33.
go back to reference Sijtsma K, Molenaar IW. Introduction to nonparametric item response theory, vol. 5. Thousand Oaks, CA: Sage Publications; 2002.CrossRef Sijtsma K, Molenaar IW. Introduction to nonparametric item response theory, vol. 5. Thousand Oaks, CA: Sage Publications; 2002.CrossRef
34.
go back to reference Molenaar IW, Sijtsma K. User's manual MSP5 for windows [software manual]. IEC ProGAMMA: Groningen, The Netherlands; 2000. Molenaar IW, Sijtsma K. User's manual MSP5 for windows [software manual]. IEC ProGAMMA: Groningen, The Netherlands; 2000.
35.
go back to reference Müller-Schneider T. Multiple Skalierung nach dem Kristallisationsprinzip. Eine alternative zur explorativen Faktorenanalyse [multiple scaling according to the principle of crystallization. An alternative method to exploratory factor analysis]. Z Soziol. 2001;30(4):305–15. Müller-Schneider T. Multiple Skalierung nach dem Kristallisationsprinzip. Eine alternative zur explorativen Faktorenanalyse [multiple scaling according to the principle of crystallization. An alternative method to exploratory factor analysis]. Z Soziol. 2001;30(4):305–15.
36.
go back to reference Schwab CGG. [Construct validity and internal consistency of the instrument “burden in dealing with dementia” (BelaDem) in nursing homes - unpublished master thesis] Konstruktvalidität und interne Konsistenz des Instrumentes “Belastungserleben im Umgang mit Demenz” (BelaDem) in der stationären Altenhilfe - unveröffentlichte Masterarbeit. Herdecke: Witten: Universität Witten/Herdecke; 2013. Schwab CGG. [Construct validity and internal consistency of the instrument “burden in dealing with dementia” (BelaDem) in nursing homes - unpublished master thesis] Konstruktvalidität und interne Konsistenz des Instrumentes “Belastungserleben im Umgang mit Demenz” (BelaDem) in der stationären Altenhilfe - unveröffentlichte Masterarbeit. Herdecke: Witten: Universität Witten/Herdecke; 2013.
37.
go back to reference Van Ginkel JR, Andries van Der Ark LA, Sijtsma K, Vermunt JK. two-way imputation: a Bayesian method for estimating missing scores in tests and questionnaires, and an accurate approximation. Computational Statistics & Data Analysis. 2007;51(8):4013–27.CrossRef Van Ginkel JR, Andries van Der Ark LA, Sijtsma K, Vermunt JK. two-way imputation: a Bayesian method for estimating missing scores in tests and questionnaires, and an accurate approximation. Computational Statistics & Data Analysis. 2007;51(8):4013–27.CrossRef
38.
go back to reference Sijtsma K, Molenaar IW. Reliability of test scores in nonparametric item response theory. Psychometrika. 1987;52.CrossRef Sijtsma K, Molenaar IW. Reliability of test scores in nonparametric item response theory. Psychometrika. 1987;52.CrossRef
39.
go back to reference van der Ark LA, van der Palm DW, Sijtsma K. A latent class approach to estimating test-score reliability. Appl Psychol Meas. 2011;35(5):380–92.CrossRef van der Ark LA, van der Palm DW, Sijtsma K. A latent class approach to estimating test-score reliability. Appl Psychol Meas. 2011;35(5):380–92.CrossRef
40.
go back to reference Terwee CB, Bot SD, de Boer MR, van der Windt DA, Knol DL, Dekker J, Bouter LM, de Vet HC. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60(1):34–42.CrossRef Terwee CB, Bot SD, de Boer MR, van der Windt DA, Knol DL, Dekker J, Bouter LM, de Vet HC. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60(1):34–42.CrossRef
41.
go back to reference Bortz J, Döring N, Bortz D. [Research methods and evaluation: for human and social sciences] Forschungsmethoden und Evaluation: für Human- und Sozialwissenschaftler, fourth revised edition edn. Heidelberg: Springer-Medizin-Verlag; 2006.CrossRef Bortz J, Döring N, Bortz D. [Research methods and evaluation: for human and social sciences] Forschungsmethoden und Evaluation: für Human- und Sozialwissenschaftler, fourth revised edition edn. Heidelberg: Springer-Medizin-Verlag; 2006.CrossRef
42.
go back to reference Core R. Team R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2017. Core R. Team R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2017.
43.
go back to reference van der Ark LA. Mokken scale analysis in R. J Stat Softw. 2007;20(11):19. van der Ark LA. Mokken scale analysis in R. J Stat Softw. 2007;20(11):19.
44.
go back to reference van der Ark LA. New developments in Mokken scale analysis in R. J Stat Softw. 2012;48(5):27. van der Ark LA. New developments in Mokken scale analysis in R. J Stat Softw. 2012;48(5):27.
46.
go back to reference Straat JH, van der Ark LA, Klaas S. minimum sample size requirements for Mokken scale analysis. Educ Psychol Meas. 2014;74(5):809–22.CrossRef Straat JH, van der Ark LA, Klaas S. minimum sample size requirements for Mokken scale analysis. Educ Psychol Meas. 2014;74(5):809–22.CrossRef
47.
go back to reference Reise SP, Kim DS, Mansolf M, Widaman KF. Is the Bifactor model a better model or is it just better at modeling implausible responses? Application of iteratively reweighted least squares to the Rosenberg self-esteem scale. Multivariate Behav Res. 2016;51(6):818–38.PubMedPubMedCentral Reise SP, Kim DS, Mansolf M, Widaman KF. Is the Bifactor model a better model or is it just better at modeling implausible responses? Application of iteratively reweighted least squares to the Rosenberg self-esteem scale. Multivariate Behav Res. 2016;51(6):818–38.PubMedPubMedCentral
48.
go back to reference Smits IAM, Timmerman ME, Meijer RR. Exploratory Mokken scale analysis as a dimensionality assessment tool: why scalability does not imply Unidimensionality. Appl Psychol Meas. 2012;36(6):516–39.CrossRef Smits IAM, Timmerman ME, Meijer RR. Exploratory Mokken scale analysis as a dimensionality assessment tool: why scalability does not imply Unidimensionality. Appl Psychol Meas. 2012;36(6):516–39.CrossRef
Metadata
Title
Item distribution, internal consistency, and structural validity of the German version of the DEMQOL and DEMQOL–proxy
Authors
Christian G. G. Schwab
Martin Nikolaus Dichter
Martin Berwig
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2018
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-018-0930-0

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