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19-12-2023 | What's New in Intensive Care

It’s about time: circadian medicine in the intensive care unit

Authors: Alawi Luetz, Claudia Spies, Laura Kervezee

Published in: Intensive Care Medicine | Issue 2/2024

Excerpt

Many aspects of human physiology are regulated by the circadian clock, the endogenous timing system that produces 24-hour rhythms not only in sleep-wake cycles but also in other bodily functions such as hormone levels, metabolism, immunity, and lung and cardiovascular function [1]. Consisting of a central clock in the suprachiasmatic nucleus (SCN) and peripheral clocks in virtually all cells in the body, the circadian system is driven by a molecular machinery that generates 24-hour rhythms in the expression of thousands of genes in a tissue-specific manner [2]. It is increasingly recognised that the circadian clock is fundamental for health and that a better understanding of this system can potentially improve patient outcomes across the healthcare system [3]. Here, we discuss the opportunities for circadian medicine in the intensive care unit (ICU). …

NCT05627167, NCT05795881, NCT04737200, NCT04870554.

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Title: It’s about time: circadian medicine in the intensive care unit
Authors: Alawi Luetz
Claudia Spies
Laura Kervezee
Publication date: 19-12-2023
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 2/2024
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-023-07297-0

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It’s about time: circadian medicine in the intensive care unit

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