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Journal of Gastrointestinal Cancer
Published in: Journal of Gastrointestinal Cancer 1-2/2009

01-06-2009

Isolated Skull Base Metastasis as the First Manifestation of Hepatocellular Carcinoma—A Rare Case Report with Review of Literature

Authors: Priti Trivedi, Anuja Gupta, Sunil Pasricha, Gaurav Agrawal, Manoj Shah

Published in: Journal of Gastrointestinal Cancer | Issue 1-2/2009

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Abstract

Introduction

Hepatocellular carcinoma rarely metastasizes to skull base.

Case Report

We report an extremely rare case of solitary skull base metastasis without metastasis to any other site, with right third, fourth, and sixth cranial nerve palsy as the initial manifestation of the disease.

Discussion

The biopsy specimen of skull base lytic lesion suggested metastatic hepatocellular carcinoma. Subsequent examination revealed a large mass involving superior segment of right lobe of liver, which was confirmed as hepatocellular carcinoma on histopathological examination.

Conclusion

Until now, there have been only 24 cases of hepatocellular carcinoma metastasizing to skull base cited in literature. We report here an unusual case of solitary skull base metastasis from hepatocellular carcinoma prior to the diagnosis of primary tumor.
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Metadata
Title
Isolated Skull Base Metastasis as the First Manifestation of Hepatocellular Carcinoma—A Rare Case Report with Review of Literature
Authors
Priti Trivedi
Anuja Gupta
Sunil Pasricha
Gaurav Agrawal
Manoj Shah
Publication date
01-06-2009
Publisher
Humana Press Inc
Published in
Journal of Gastrointestinal Cancer / Issue 1-2/2009
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-009-9081-z

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