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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-02-2014 | Review Article

Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations

Authors: Keiichiro Yoshinaga, Masanao Naya, Tohru Shiga, Eriko Suzuki, Nagara Tamaki

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2014

Abstract

“Ischaemic memory” is defined as a prolonged functional and/or biochemical alteration remaining after a particular episode of severe myocardial ischaemia. The biochemical alteration has been reported as metabolic stunning. Metabolic imaging has been used to detect the footprint left by previous ischaemic episodes evident due to delayed recovery of myocardial metabolism (persistent dominant glucose utilization with suppression of fatty acid oxidation). β-Methyl-p-[¹²³I]iodophenylpentadecanoic acid (BMIPP) is a single-photon emission computed tomography (SPECT) radiotracer widely used for metabolic imaging in clinical settings in Japan. In patients with suspected coronary artery disease but no previous myocardial infarction, BMIPP has shown acceptable diagnostic accuracy. In particular, BMIPP plays an important role in the identification of prior ischaemic insult in patients arriving at emergency departments with acute chest pain syndrome. Recent data also show the usefulness of ¹²³I-BMIPP SPECT for predicting cardiovascular events in patients undergoing haemodialysis. Similarly, SPECT or PET imaging with ¹⁸F-FDG injected during peak exercise or after exercise under fasting conditions shows an increase in FDG uptake in postischaemic areas. This article will overview the roles of ischaemic memory imaging both under established indications and in ongoing investigations.

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Title: Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations
Authors: Keiichiro Yoshinaga
Masanao Naya
Tohru Shiga
Eriko Suzuki
Nagara Tamaki
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2014
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2615-4

At a glance: The STEP trials

Springer Medicine

Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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