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International Journal of Clinical Pharmacy
Published in: International Journal of Clinical Pharmacy 5/2015

01-10-2015 | Editorial

Is your love in vain? On associations between genotypes, drug concentrations and clinical outcomes in pharmacogenomic research

Author: Per Damkier

Published in: International Journal of Clinical Pharmacy | Issue 5/2015

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Excerpt

In this issue of IJCP, Chawla et al. [1] report on an association between CYP2C19 genotype and plasma voriconazole levels. Based on retrospective data on voriconazole dose, plasma concentration levels, and CYP2C19 genotypes in 55 patients, the authors conclude, “…voriconazole monitoring and genotype analysis may assist in clinical practice and better patient care”, and suggest impact on clinical practice: “CYP2C19 genotype and voriconazole monitoring at initiation……is required to achieve therapeutic targets”. …
Literature
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Chawla PK, Nanday SR, Dherai AJ, Soman R, Lokhande RV, Naik PR, Ashavaid TF. Correlation of CYP2C19 genotype with plasma voriconazole levels: a preliminary retrospective study in Indians. IJCP-D-14-00610R2.
2.
Attia J, Ioannidis JP, Thakkinstian A, McEvoy M, Scott RJ, Minelli C, Thompson J, et al. How to use an article about genetic association: B: are the results of the study valid? JAMA. 2009;301:191–7.CrossRefPubMed
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Attia J, Ioannidis JP, Thakkinstian A, McEvoy M, Scott RJ, Minelli C, Thompson J, et al. How to use an article about genetic association: C: what are the results and will they help me in caring for my patients? JAMA. 2009;301:304–8.CrossRefPubMed
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Kalia M. Biomarkers for personalized oncology: recent advances and future challenges. Metabolism. 2015;64:16–21.CrossRef
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Rodríguez-Antona C, Taron M. Pharmacogenomic biomarkers for personalized cancer treatment. J Intern Med. 2015;277:201–17.CrossRefPubMed
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Dunnenberger HM, Crews KR, Hoffman JM, Caudle KE, Broeckel U, Howard SC, et al. Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers. Annu Rev Pharmacol Toxicol. 2015;55:89–106.CrossRefPubMed
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Janssens AC, Deverka PA. Useless until proven effective: the clinical utility of preemptive pharmacogenetic testing. Clin Pharmacol Ther. 2014;96:652–4.CrossRefPubMed
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Jameson JL, Longo DL. Precision medicine—personalized, problematic, and promising. N Engl J Med. 2015;372:2229–34.CrossRefPubMed
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Pirmohamed M, Burnside G, Eriksson N, Jorgensen AL, Toh CH, Nicholson T, et al. EU-PACT group. A randomized trial of genotype-guided dosing of warfarin. N Engl J Med. 2013;369:2294–303.CrossRefPubMed
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Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF, et al. COAG investigators. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med. 2013;369:2283–93.PubMedCentralCrossRefPubMed
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Metadata
Title
Is your love in vain? On associations between genotypes, drug concentrations and clinical outcomes in pharmacogenomic research
Author
Per Damkier
Publication date
01-10-2015
Publisher
Springer Netherlands
Published in
International Journal of Clinical Pharmacy / Issue 5/2015
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-015-0167-3

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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