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01-06-2016 | WHAT’S NEW IN INTENSIVE CARE

Is this critically ill patient immunocompromised?

Authors: Frédéric Pène, Peter Pickkers, Richard S. Hotchkiss

Published in: Intensive Care Medicine | Issue 6/2016

Excerpt

In a very real sense, sepsis illustrates the multiple dimensions of the immune response of critically ill patients. On the one hand, sepsis can be viewed as the simple result of the interplay between a pathogen and the immune response to that pathogen. On the other hand, it is becoming clearer that this interplay is much more complex than it appeared. It often leads to major defects in immunity during recovery, conferring increased susceptibility to secondary infections and leading to worsened outcomes [1, 2]. …

Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138–150CrossRefPubMed

Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P (2013) Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 187:1287–1293CrossRefPubMed

Daviaud F, Grimaldi D, Dechartres A, Charpentier J, Geri G, Marin N, Chiche JD, Cariou A, Mira JP, Pene F (2015) Timing and causes of death in septic shock. Ann Intensive Care 5:58CrossRef

Petersen L, Andersen PK, Sorensen TI (2010) Genetic influences on incidence and case-fatality of infectious disease. PLoS One 5:e10603CrossRefPubMedPubMedCentral

Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG (2014) Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science 345:1251086CrossRefPubMedPubMedCentral

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med 43:1165–1169CrossRefPubMed

Grimaldi D, Le Bourhis L, Sauneuf B, Dechartres A, Rousseau C, Ouaaz F, Milder M, Louis D, Chiche JD, Mira JP, Lantz O, Pene F (2014) Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections. Intensive Care Med 40:192–201CrossRefPubMed

Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874CrossRefPubMedPubMedCentral

Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS (2014) Reactivation of multiple viruses in patients with sepsis. PLoS One 9:e98819CrossRefPubMedPubMedCentral

10.

Asehnoune K, Roquilly A, Abraham E (2012) Innate immune dysfunction in trauma patients: from pathophysiology to treatment. Anesthesiology 117:411–416CrossRefPubMed

11.

Manez R, Kusne S, Linden P, Gonzalez-Pinto I, Bonet H, Kramer D, Fung JJ, Starzl TE (1994) Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation. Transplantation 57:149–151CrossRefPubMedPubMedCentral

12.

Lukaszewicz AC, Grienay M, Resche-Rigon M, Pirracchio R, Faivre V, Boval B, Payen D (2009) Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction. Crit Care Med 37:2746–2752CrossRefPubMed

13.

Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 180:640–648CrossRefPubMed

14.

Demaret J, Villars-Mechin A, Lepape A, Plassais J, Vallin H, Malcus C, Poitevin-Later F, Monneret G, Venet F (2014) Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients. Intensive Care Med 40:1089–1096CrossRefPubMed

15.

Landelle C, Lepape A, Voirin N, Tognet E, Venet F, Bohe J, Vanhems P, Monneret G (2010) Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 36:1859–1866CrossRefPubMed

16.

Venet F, Foray AP, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G (2012) IL-7 restores lymphocyte functions in septic patients. J Immunol 189:5073–5081CrossRefPubMed

17.

Wu J, Zhou L, Liu J, Ma G, Kou Q, He Z, Chen J, Ou-Yang B, Chen M, Li Y, Wu X, Gu B, Chen L, Zou Z, Qiang X, Chen Y, Lin A, Zhang G, Guan X (2013) The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care 17:R8CrossRefPubMedPubMedCentral

18.

Hotchkiss RS, Moldawer LL (2014) Parallels between cancer and infectious disease. N Engl J Med 371:380–383CrossRefPubMed

Title: Is this critically ill patient immunocompromised?
Authors: Frédéric Pène
Peter Pickkers
Richard S. Hotchkiss
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 6/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-015-4161-y

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Is this critically ill patient immunocompromised?

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