A 21 year-old male intravenous drug user with severe aortic and mitral regurgitation from bacterial endocarditis went to operation. Ventricular fibrillatory arrest occurred shortly after induction of anesthesia, and salvage double valve replacement requiring postcardiotomy veno-arterial extracorporeal membrane (VA-ECMO) via central cannulation ensued. On post-operative day two, transesophageal echocardiography showed bioprosthetic mitral valve thrombosis (Fig. 1a). The patient ultimately died.