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Published in: Current Cardiology Reports 4/2022

01-04-2022 | Psychological Aspects of Cardiovascular Diseases (IM Kronish , Section Editor)

Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease?

Authors: Andrea T. Duran, Emily Romero, Keith M. Diaz

Published in: Current Cardiology Reports | Issue 4/2022

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Abstract

Purpose of Review

Review the most recent evidence on the role of sedentary behavior in the prevention of cardiovascular disease (CVD).

Recent Findings

Prospective cohort studies continue to suggest a relationship between sedentary behavior and CVD, but the dose–response association, and the implications of sedentary pattern (vs. total volume) and context on CVD risk require further investigation. Most recent evidence suggests that physical activity influences the association between sedentary time and CVD risk, and that replacing sedentary time with other movement behaviors yields cardiometabolic benefits. Short-term intervention studies have further demonstrated that interrupting prolonged sitting with bouts of physical activity can elicit acute improvements on cardiometabolic biomarkers and vascular function relative to prolonged, uninterrupted sitting, albeit limited evidence exists on the long-term effects.

Summary

More conclusive evidence regarding the implications of sedentary time on CVD risk is warranted before the optimal sedentary behavior reduction prescription for the prevention of CVD can be elucidated.
Literature
1.
go back to reference Virani SS, et al. Heart Disease and Stroke Statistics-2021 Update: a report from the American Heart Association. Circulation. 2021;143(8):e254–743.PubMedCrossRef Virani SS, et al. Heart Disease and Stroke Statistics-2021 Update: a report from the American Heart Association. Circulation. 2021;143(8):e254–743.PubMedCrossRef
2.
go back to reference Lloyd-Jones DM, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic Impact Goal through 2020 and beyond. Circulation. 2010;121(4):586–613.PubMedCrossRef Lloyd-Jones DM, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic Impact Goal through 2020 and beyond. Circulation. 2010;121(4):586–613.PubMedCrossRef
3.
go back to reference Powell KE, et al. The Scientific Foundation for the Physical Activity Guidelines for Americans, 2nd Edition. J Phys Act Health, 2018: p. 1–11. Powell KE, et al. The Scientific Foundation for the Physical Activity Guidelines for Americans, 2nd Edition. J Phys Act Health, 2018: p. 1–11.
4.
go back to reference Authors/Task Force M, et al. European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur J Prev Cardiol. 2016;23(11): p. NP1-NP96. Authors/Task Force M, et al. European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur J Prev Cardiol. 2016;23(11): p. NP1-NP96.
5.
go back to reference World Health Organization, Global health risks : mortality and burden of disease attributable to selected major risks., W.H. Organization, Editor. Geneva: World Health Organization: Geneva, Switzerland. 2009. World Health Organization, Global health risks : mortality and burden of disease attributable to selected major risks., W.H. Organization, Editor. Geneva: World Health Organization: Geneva, Switzerland. 2009.
6.
go back to reference Roger VL, et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18–209.PubMedCrossRef Roger VL, et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18–209.PubMedCrossRef
7.
go back to reference Wilmot EG, et al. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 2012;55(11):2895–905.PubMedCrossRef Wilmot EG, et al. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 2012;55(11):2895–905.PubMedCrossRef
8.
go back to reference Dunstan DW, et al. Too much sitting—a health hazard. Diabetes Res Clin Pract. 2012;97(3):368–76.PubMedCrossRef Dunstan DW, et al. Too much sitting—a health hazard. Diabetes Res Clin Pract. 2012;97(3):368–76.PubMedCrossRef
9.
10.
go back to reference Diaz KM, et al. Patterns of Sedentary behavior and mortality in U.S. middle-aged and older adults: a national cohort study. Ann Intern Med. 2017;167(7):465–75. Diaz KM, et al. Patterns of Sedentary behavior and mortality in U.S. middle-aged and older adults: a national cohort study. Ann Intern Med. 2017;167(7):465–75.
11.
go back to reference Du Y, et al. Trends in adherence to the physical activity guidelines for Americans for Aerobic activity and time spent on sedentary behavior among US adults, 2007 to 2016. JAMA Netw Open. 2019;2(7):e197597.PubMedPubMedCentralCrossRef Du Y, et al. Trends in adherence to the physical activity guidelines for Americans for Aerobic activity and time spent on sedentary behavior among US adults, 2007 to 2016. JAMA Netw Open. 2019;2(7):e197597.PubMedPubMedCentralCrossRef
12.
go back to reference Matthews CE, et al. Amount of time spent in sedentary behaviors in the United States, 2003–2004. Am J Epidemiol. 2008;167(7):875–81.PubMedCrossRef Matthews CE, et al. Amount of time spent in sedentary behaviors in the United States, 2003–2004. Am J Epidemiol. 2008;167(7):875–81.PubMedCrossRef
13.
go back to reference Prince SA, et al. A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta-analysis of controlled trials. Obes Rev. 2014;15(11):905–19.PubMedPubMedCentralCrossRef Prince SA, et al. A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta-analysis of controlled trials. Obes Rev. 2014;15(11):905–19.PubMedPubMedCentralCrossRef
14.
go back to reference Davies SAF, McBride M, Calderwood C. UK Chief Medical Officers' Physical Activity Guidelines. Chief Medical Officers: Chief Medical Officers 2019. Davies SAF, McBride M, Calderwood C. UK Chief Medical Officers' Physical Activity Guidelines. Chief Medical Officers: Chief Medical Officers 2019.
15.
go back to reference World Health Organization. Global recommendations on physical activity for health, W.H. Organization, Editor. Geneva, Switzerland. 2010;58. World Health Organization. Global recommendations on physical activity for health, W.H. Organization, Editor. Geneva, Switzerland. 2010;58.
16.
go back to reference Ministry of Health, Eating and Activity Guidelines for New Zealand Adults: Updated 2020. 2020, Ministry of Health: Wellington. Ministry of Health, Eating and Activity Guidelines for New Zealand Adults: Updated 2020. 2020, Ministry of Health: Wellington.
17.
go back to reference Australian Government Department of Health, Physical activity and exercise guidelines for all Australians. Department Health Website. 2021. Australian Government Department of Health, Physical activity and exercise guidelines for all Australians. Department Health Website. 2021.
18.
go back to reference Tremblay MS, et al. Canadian 24-hour movement guidelines for children and youth: an integration of physical activity, sedentary behaviour, and sleep. Appl Physiol Nutr Metab. 2016;41(6 Suppl 3):S311–27.PubMedCrossRef Tremblay MS, et al. Canadian 24-hour movement guidelines for children and youth: an integration of physical activity, sedentary behaviour, and sleep. Appl Physiol Nutr Metab. 2016;41(6 Suppl 3):S311–27.PubMedCrossRef
19.
go back to reference Fuzeki EL, Vogt BW. [German National Physical Activity Recommendations for Adults and Older Adults: Methods, Database and Rationale]. Gesundheitswesen. 2017;79(S01):S20–28 Fuzeki EL, Vogt BW. [German National Physical Activity Recommendations for Adults and Older Adults: Methods, Database and Rationale]. Gesundheitswesen. 2017;79(S01):S20–28
20.
go back to reference Colberg SR, et al. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065–79.PubMedPubMedCentralCrossRef Colberg SR, et al. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065–79.PubMedPubMedCentralCrossRef
21.
go back to reference Committee PAGA. Physical Activity Guidelines Advisory Committee Scientific Report, D.o.H.a.H. Services, Editor. Washington, DC. 2018. Committee PAGA. Physical Activity Guidelines Advisory Committee Scientific Report, D.o.H.a.H. Services, Editor. Washington, DC. 2018.
22.
go back to reference Katzmarzyk PT, et al. Sedentary behavior and health: update from the 2018 physical activity guidelines advisory committee. Med Sci Sports Exerc. 2019;51(6):1227–41.PubMedPubMedCentralCrossRef Katzmarzyk PT, et al. Sedentary behavior and health: update from the 2018 physical activity guidelines advisory committee. Med Sci Sports Exerc. 2019;51(6):1227–41.PubMedPubMedCentralCrossRef
23.
24.
go back to reference Tremblay MS, et al. Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act. 2017;14(1):75.PubMedPubMedCentralCrossRef Tremblay MS, et al. Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act. 2017;14(1):75.PubMedPubMedCentralCrossRef
25.
go back to reference Endorsed by The Obesity S, et al. Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the American Heart Association. Circulation. 2016;134(13):e262–79. Endorsed by The Obesity S, et al. Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the American Heart Association. Circulation. 2016;134(13):e262–79.
26.
go back to reference Garber CE, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59 Garber CE, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59
30.
go back to reference Yu L, et al. Sedentary behavior and the risk of cardiac-cerebral vascular diseases in southern China. Medicine (Baltimore). 2018;97(44):e12838. Yu L, et al. Sedentary behavior and the risk of cardiac-cerebral vascular diseases in southern China. Medicine (Baltimore). 2018;97(44):e12838.
31.
go back to reference Dempsey PC, et al. Associations of context-specific sitting time with markers of cardiometabolic risk in Australian adults. Int J Behav Nutr Phys Act. 2018;15(1):114.PubMedPubMedCentralCrossRef Dempsey PC, et al. Associations of context-specific sitting time with markers of cardiometabolic risk in Australian adults. Int J Behav Nutr Phys Act. 2018;15(1):114.PubMedPubMedCentralCrossRef
32.
go back to reference Lee Y, et al. Association of sedentary time and physical activity with the 10-year risk of cardiovascular disease: Korea National Health and Nutrition Examination Survey 2014–2017. Korean J Fam Med. 2020;41(6):374–80.PubMedPubMedCentralCrossRef Lee Y, et al. Association of sedentary time and physical activity with the 10-year risk of cardiovascular disease: Korea National Health and Nutrition Examination Survey 2014–2017. Korean J Fam Med. 2020;41(6):374–80.PubMedPubMedCentralCrossRef
33.
go back to reference Bellettiere J, et al. Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults. PLoS One. 2017;12(6):e0180119 Bellettiere J, et al. Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults. PLoS One. 2017;12(6):e0180119
34.
go back to reference Smith P, et al. The relationship between occupational standing and sitting and incident heart disease over a 12-year period in Ontario. Canada Am J Epidemiol. 2018;187(1):27–33.PubMedCrossRef Smith P, et al. The relationship between occupational standing and sitting and incident heart disease over a 12-year period in Ontario. Canada Am J Epidemiol. 2018;187(1):27–33.PubMedCrossRef
35.
go back to reference Jefferis BJ, et al. Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men. Int J Cardiol. 2019;278:267–72.PubMedPubMedCentralCrossRef Jefferis BJ, et al. Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men. Int J Cardiol. 2019;278:267–72.PubMedPubMedCentralCrossRef
36.
go back to reference Dohrn IM, Welmer AK, Hagströmer M. Accelerometry-assessed physical activity and sedentary time and associations with chronic disease and hospital visits — a prospective cohort study with 15 years follow-up. Int J Behav Nutr Phys Act. 2019;16(1):125.PubMedPubMedCentralCrossRef Dohrn IM, Welmer AK, Hagströmer M. Accelerometry-assessed physical activity and sedentary time and associations with chronic disease and hospital visits — a prospective cohort study with 15 years follow-up. Int J Behav Nutr Phys Act. 2019;16(1):125.PubMedPubMedCentralCrossRef
37.
go back to reference Bellettiere J, et al. Sedentary behavior and cardiovascular disease in older women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study. Circulation. 2019;139(8):1036–46.PubMedPubMedCentralCrossRef Bellettiere J, et al. Sedentary behavior and cardiovascular disease in older women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study. Circulation. 2019;139(8):1036–46.PubMedPubMedCentralCrossRef
38.
go back to reference Evenson KR, Wen F, Herring AH. Associations of accelerometry-assessed and self-reported physical activity and sedentary behavior with all-cause and cardiovascular mortality among US adults. Am J Epidemiol. 2016;184(9):621–32.PubMedPubMedCentralCrossRef Evenson KR, Wen F, Herring AH. Associations of accelerometry-assessed and self-reported physical activity and sedentary behavior with all-cause and cardiovascular mortality among US adults. Am J Epidemiol. 2016;184(9):621–32.PubMedPubMedCentralCrossRef
40.
go back to reference Ekelund U, et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019;366:l4570. Ekelund U, et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019;366:l4570.
41.
go back to reference Patterson R, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Eur J Epidemiol. 2018;33(9):811–29.PubMedPubMedCentralCrossRef Patterson R, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Eur J Epidemiol. 2018;33(9):811–29.PubMedPubMedCentralCrossRef
42.
go back to reference Pandey A, et al. Continuous dose-response association between sedentary time and risk for cardiovascular disease: a meta-analysis. JAMA Cardiol. 2016;1(5):575–83.PubMedCrossRef Pandey A, et al. Continuous dose-response association between sedentary time and risk for cardiovascular disease: a meta-analysis. JAMA Cardiol. 2016;1(5):575–83.PubMedCrossRef
43.
go back to reference Dempsey PC, et al. Prospective associations of accelerometer-measured physical activity and sedentary time with incident cardiovascular disease, cancer, and all-cause mortality. Circulation. 2020;141(13):1113–5.PubMedCrossRef Dempsey PC, et al. Prospective associations of accelerometer-measured physical activity and sedentary time with incident cardiovascular disease, cancer, and all-cause mortality. Circulation. 2020;141(13):1113–5.PubMedCrossRef
44.
go back to reference Healy GN, et al. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008;31(4):661–6.PubMedCrossRef Healy GN, et al. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008;31(4):661–6.PubMedCrossRef
45.
go back to reference • Loh R, et al. Effects of interrupting prolonged sitting with physical activity breaks on blood glucose, insulin and triacylglycerol measures: a systematic review and meta-analysis. Sports Med. 2020;50(2): p. 295–330. Findings from this meta-analysis of short-term interventions suggest that breaking up prolonged, uniterrupted sedentary time with bouts of physical activity attenuates glucose and insulin. • Loh R, et al. Effects of interrupting prolonged sitting with physical activity breaks on blood glucose, insulin and triacylglycerol measures: a systematic review and meta-analysis. Sports Med. 2020;50(2): p. 295–330. Findings from this meta-analysis of short-term interventions suggest that breaking up prolonged, uniterrupted sedentary time with bouts of physical activity attenuates glucose and insulin.
46.
go back to reference Saunders TJ, et al. The acute metabolic and vascular impact of interrupting prolonged sitting: a systematic review and meta-analysis. Sports Med. 2018;48(10):2347–66.PubMedCrossRef Saunders TJ, et al. The acute metabolic and vascular impact of interrupting prolonged sitting: a systematic review and meta-analysis. Sports Med. 2018;48(10):2347–66.PubMedCrossRef
47.
go back to reference Corraini P, et al. Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators. Clin Epidemiol. 2017;9:331–8.PubMedPubMedCentralCrossRef Corraini P, et al. Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators. Clin Epidemiol. 2017;9:331–8.PubMedPubMedCentralCrossRef
48.
49.
go back to reference Chastin SF, et al. Combined effects of time spent in physical activity, sedentary behaviors and sleep on obesity and cardio-metabolic health markers: a novel compositional data analysis approach. PLoS One. 2015;10(10):e0139984. Chastin SF, et al. Combined effects of time spent in physical activity, sedentary behaviors and sleep on obesity and cardio-metabolic health markers: a novel compositional data analysis approach. PLoS One. 2015;10(10):e0139984.
50.
go back to reference •• Ekelund U, et al. Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants. Br J Sports Med. 2019;53(14):886–94. https://doi.org/10.1136/bjsports-2017-098963. Epub 2018 Jul 10. PMID: 29991570. Findings from this meta-analysis of prospective cohort studies suggest that different levels of physical activity attenuate the dose-response association between self-reported sedentary behavior and CVD mortality. •• Ekelund U, et al. Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants. Br J Sports Med. 2019;53(14):886–94. https://​doi.​org/​10.​1136/​bjsports-2017-098963. Epub 2018 Jul 10. PMID: 29991570. Findings from this meta-analysis of prospective cohort studies suggest that different levels of physical activity attenuate the dose-response association between self-reported sedentary behavior and CVD mortality.
51.
go back to reference Stamatakis E, et al. Sitting time, physical activity, and risk of mortality in adults. J Am Coll Cardiol. 2019;73(16):2062–72.PubMedCrossRef Stamatakis E, et al. Sitting time, physical activity, and risk of mortality in adults. J Am Coll Cardiol. 2019;73(16):2062–72.PubMedCrossRef
52.
go back to reference Ballin M, et al. Associations of objectively measured physical activity and sedentary time with the risk of stroke, myocardial infarction or all-cause mortality in 70-year-old men and women: a prospective cohort study. Sports Med. 2021;51(2):339–49.PubMedCrossRef Ballin M, et al. Associations of objectively measured physical activity and sedentary time with the risk of stroke, myocardial infarction or all-cause mortality in 70-year-old men and women: a prospective cohort study. Sports Med. 2021;51(2):339–49.PubMedCrossRef
53.
go back to reference Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, Bauman A, Lee IM. Lancet physical activity series 2 executive committe; Lancet sedentary behaviour working group. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet. 2016;388(10051):1302-10. https://doi.org/10.1016/S0140-6736(16)30370-1. Epub 2016 Jul 28. Erratum in: Lancet. 2016 Sep 24;388(10051):e6. PMID: 27475271. Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, Bauman A, Lee IM. Lancet physical activity series 2 executive committe; Lancet sedentary behaviour working group. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet. 2016;388(10051):1302-10. https://​doi.​org/​10.​1016/​S0140-6736(16)30370-1. Epub 2016 Jul 28. Erratum in: Lancet. 2016 Sep 24;388(10051):e6. PMID: 27475271.
54.
go back to reference Del Pozo-Cruz J, et al. Replacing sedentary time: meta-analysis of objective-assessment studies. Am J Prev Med. 2018;55(3):395–402.PubMedCrossRef Del Pozo-Cruz J, et al. Replacing sedentary time: meta-analysis of objective-assessment studies. Am J Prev Med. 2018;55(3):395–402.PubMedCrossRef
55.
go back to reference Whitaker, KM, et al. Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: the CARDIA study. J Am Heart Assoc. 2019;8(1):e010212. Whitaker, KM, et al. Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: the CARDIA study. J Am Heart Assoc. 2019;8(1):e010212.
56.
57.
go back to reference Takagi H, et al. Meta-analysis of the relation of television-viewing time and cardiovascular disease. Am J Cardiol. 2019;124(11):1674–83.PubMedCrossRef Takagi H, et al. Meta-analysis of the relation of television-viewing time and cardiovascular disease. Am J Cardiol. 2019;124(11):1674–83.PubMedCrossRef
58.
go back to reference Thorp AA, et al. Sedentary behaviors and subsequent health outcomes in adults a systematic review of longitudinal studies, 1996–2011. Am J Prev Med. 2011;41(2):207–15.PubMedCrossRef Thorp AA, et al. Sedentary behaviors and subsequent health outcomes in adults a systematic review of longitudinal studies, 1996–2011. Am J Prev Med. 2011;41(2):207–15.PubMedCrossRef
59.
go back to reference van Uffelen JG, et al. Occupational sitting and health risks: a systematic review. Am J Prev Med. 2010;39(4):379–88.PubMedCrossRef van Uffelen JG, et al. Occupational sitting and health risks: a systematic review. Am J Prev Med. 2010;39(4):379–88.PubMedCrossRef
60.
go back to reference Garcia JM, et al. Types of sedentary behavior and risk of cardiovascular events and mortality in blacks: the Jackson heart study. J Am Heart Assoc. 2019;8(13):e010406. Garcia JM, et al. Types of sedentary behavior and risk of cardiovascular events and mortality in blacks: the Jackson heart study. J Am Heart Assoc. 2019;8(13):e010406.
61.
go back to reference Møller SV, et al. Multi-wave cohort study of sedentary work and risk of ischemic heart disease. Scand J Work Environ Health. 2016;42(1):43–51.PubMedCrossRef Møller SV, et al. Multi-wave cohort study of sedentary work and risk of ischemic heart disease. Scand J Work Environ Health. 2016;42(1):43–51.PubMedCrossRef
62.
go back to reference Stamatakis E, et al. Is the time right for quantitative public health guidelines on sitting? A narrative review of sedentary behaviour research paradigms and findings. Br J Sports Med. 2019;53(6):377–82.PubMedCrossRef Stamatakis E, et al. Is the time right for quantitative public health guidelines on sitting? A narrative review of sedentary behaviour research paradigms and findings. Br J Sports Med. 2019;53(6):377–82.PubMedCrossRef
63.
go back to reference Hamer M, et al. Association between TV viewing and heart disease mortality: observational study using negative control outcome. J Epidemiol Community Health. 2020;74(4):391–4.PubMedCrossRef Hamer M, et al. Association between TV viewing and heart disease mortality: observational study using negative control outcome. J Epidemiol Community Health. 2020;74(4):391–4.PubMedCrossRef
64.
go back to reference Zhuang Z, et al. Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis. Lipids Health Dis. 2020;19(1):86.PubMedPubMedCentralCrossRef Zhuang Z, et al. Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis. Lipids Health Dis. 2020;19(1):86.PubMedPubMedCentralCrossRef
65.
go back to reference Bahls M, et al. Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. Clin Res Cardiol. 2021. Bahls M, et al. Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. Clin Res Cardiol. 2021.
66.
go back to reference Bey L, Hamilton MT. Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity. J Physiol. 2003;551(Pt 2):673–82.PubMedPubMedCentralCrossRef Bey L, Hamilton MT. Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity. J Physiol. 2003;551(Pt 2):673–82.PubMedPubMedCentralCrossRef
67.
go back to reference Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes. 2007;56(11):2655.PubMedCrossRef Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes. 2007;56(11):2655.PubMedCrossRef
68.
go back to reference Kump DS, Booth FW. Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise. J Physiol. 2005;562(Pt 3):829–38.PubMedCrossRef Kump DS, Booth FW. Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise. J Physiol. 2005;562(Pt 3):829–38.PubMedCrossRef
69.
go back to reference Thosar SS, et al. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012;(12):Ra173–Ra1780. Thosar SS, et al. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012;(12):Ra173–Ra1780.
70.
go back to reference Padilla J, et al. Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk. J Vasc Res. 2009;46(6):592–600.PubMedCrossRef Padilla J, et al. Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk. J Vasc Res. 2009;46(6):592–600.PubMedCrossRef
71.
go back to reference Restaino RM, et al. Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress. Am J Physiol Heart Circ Physiol. 2016;310(5):H648–53.PubMedPubMedCentralCrossRef Restaino RM, et al. Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress. Am J Physiol Heart Circ Physiol. 2016;310(5):H648–53.PubMedPubMedCentralCrossRef
72.
go back to reference Padilla J, et al. Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response. Am J Physiol Heart Circ Physiol. 2009;297(3):H1103–8.PubMedCrossRef Padilla J, et al. Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response. Am J Physiol Heart Circ Physiol. 2009;297(3):H1103–8.PubMedCrossRef
73.
74.
go back to reference Morishima T, et al. Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction. Clin Sci (Lond). 2017;131(11):1045–53.CrossRef Morishima T, et al. Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction. Clin Sci (Lond). 2017;131(11):1045–53.CrossRef
75.
go back to reference Padilla J, Fadel PJ. Prolonged sitting leg vasculopathy: contributing factors and clinical implications. Am J Physiol Heart Circ Physiol. 2017;313(4):H722–H8. Padilla J, Fadel PJ. Prolonged sitting leg vasculopathy: contributing factors and clinical implications. Am J Physiol Heart Circ Physiol. 2017;313(4):H722–H8.
76.
go back to reference McManus AM, et al. Impact of prolonged sitting on vascular function in young girls. Exp Physiol. 2015;100(11):1379–87.PubMedCrossRef McManus AM, et al. Impact of prolonged sitting on vascular function in young girls. Exp Physiol. 2015;100(11):1379–87.PubMedCrossRef
77.
go back to reference Morishima T, et al. Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol. 2016;311(1):H177–82.PubMedPubMedCentralCrossRef Morishima T, et al. Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol. 2016;311(1):H177–82.PubMedPubMedCentralCrossRef
78.
go back to reference Thosar SS, et al. Effect of prolonged sitting and breaks in sitting time on endothelial function. Med Sci Sports Exerc. 2015;47(4):843–9.PubMedCrossRef Thosar SS, et al. Effect of prolonged sitting and breaks in sitting time on endothelial function. Med Sci Sports Exerc. 2015;47(4):843–9.PubMedCrossRef
79.
go back to reference Dempsey PC, et al. Sitting less and moving more: implications for hypertension. Hypertension. 2018;72(5):1037–46.PubMedCrossRef Dempsey PC, et al. Sitting less and moving more: implications for hypertension. Hypertension. 2018;72(5):1037–46.PubMedCrossRef
80.
go back to reference Carter S, et al. Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev. 2017;45(2):80–6.PubMedCrossRef Carter S, et al. Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev. 2017;45(2):80–6.PubMedCrossRef
81.
go back to reference Paterson C, et al. The effects of acute exposure to prolonged sitting, with and without interruption, on vascular function among adults: a meta-analysis. Sports Med. 2020;50(11):1929–42.PubMedCrossRef Paterson C, et al. The effects of acute exposure to prolonged sitting, with and without interruption, on vascular function among adults: a meta-analysis. Sports Med. 2020;50(11):1929–42.PubMedCrossRef
82.
go back to reference Zheng C, et al. Effect of sedentary behavior interventions on vascular function in adults: a systematic review and meta-analysis. Scand J Med Sci Sports. 2021;31(7):1395–410.PubMedCrossRef Zheng C, et al. Effect of sedentary behavior interventions on vascular function in adults: a systematic review and meta-analysis. Scand J Med Sci Sports. 2021;31(7):1395–410.PubMedCrossRef
83.
go back to reference Brierley ML, et al. The effectiveness of sedentary behaviour reduction workplace interventions on cardiometabolic risk markers: a systematic review. Sports Med. 2019;49(11):1739–67.PubMedCrossRef Brierley ML, et al. The effectiveness of sedentary behaviour reduction workplace interventions on cardiometabolic risk markers: a systematic review. Sports Med. 2019;49(11):1739–67.PubMedCrossRef
84.
go back to reference • Hadgraft NT, et al. Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta-analyses. Br J Sports Med. 2021;55(3): p. 144. Findings from this meta-analysis of free-living longer-term interventions suggest that targeting reductions in sedentary behavior alone or combined with increased physical activity exhibits improvements in several cardiometabolic biomarkers. • Hadgraft NT, et al. Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta-analyses. Br J Sports Med. 2021;55(3): p. 144. Findings from this meta-analysis of free-living longer-term interventions suggest that targeting reductions in sedentary behavior alone or combined with increased physical activity exhibits improvements in several cardiometabolic biomarkers.
85.
go back to reference Chase J-AD, et al. A systematic review and meta-analysis of interventions to reduce sedentary behavior among older adults. Transl Behav Med. 2020;10(5):1078–85.PubMedCrossRef Chase J-AD, et al. A systematic review and meta-analysis of interventions to reduce sedentary behavior among older adults. Transl Behav Med. 2020;10(5):1078–85.PubMedCrossRef
86.
go back to reference Gibbs BB, et al. Association of standing with cardiovascular disease and mortality in adults. Curr Epidemiol Rep. 2021. Gibbs BB, et al. Association of standing with cardiovascular disease and mortality in adults. Curr Epidemiol Rep. 2021.
87.
go back to reference Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol. 2002;93(2):788-96. Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol. 2002;93(2):788-96.
88.
go back to reference Cardoso CG Jr, et al. Acute and chronic effects of aerobic and resistance exercise on ambulatory blood pressure. Clinics (Sao Paulo). 2010;65(3):317–25.CrossRef Cardoso CG Jr, et al. Acute and chronic effects of aerobic and resistance exercise on ambulatory blood pressure. Clinics (Sao Paulo). 2010;65(3):317–25.CrossRef
89.
go back to reference Pescatello LS, et al. Assessing the existing professional exercise recommendations for hypertension: a review and recommendations for future research priorities. Mayo Clin Proc. 2015;90(6):801–12.PubMedCrossRef Pescatello LS, et al. Assessing the existing professional exercise recommendations for hypertension: a review and recommendations for future research priorities. Mayo Clin Proc. 2015;90(6):801–12.PubMedCrossRef
90.
go back to reference Chobanian AV, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.PubMedCrossRef Chobanian AV, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.PubMedCrossRef
91.
go back to reference Mancia G, et al. 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press. 2014;23(1):3–16.PubMedCrossRef Mancia G, et al. 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press. 2014;23(1):3–16.PubMedCrossRef
92.
go back to reference Pescatello LS, et al. American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004;36(3):533–53. Pescatello LS, et al. American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004;36(3):533–53.
93.
go back to reference Jelleyman C, et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015;16(11):942–61.PubMedCrossRef Jelleyman C, et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015;16(11):942–61.PubMedCrossRef
94.
go back to reference Tonoli C, et al. Effects of different types of acute and chronic (training) exercise on glycaemic control in type 1 diabetes mellitus: a meta-analysis. Sports Med. 2012;42(12):1059–80.PubMedCrossRef Tonoli C, et al. Effects of different types of acute and chronic (training) exercise on glycaemic control in type 1 diabetes mellitus: a meta-analysis. Sports Med. 2012;42(12):1059–80.PubMedCrossRef
Metadata
Title
Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease?
Authors
Andrea T. Duran
Emily Romero
Keith M. Diaz
Publication date
01-04-2022
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 4/2022
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-022-01657-w

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