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Annals of Hematology
Published in: Annals of Hematology 3/2012

01-03-2012 | Original Article

Is obesity a prognostic factor for acute myeloid leukemia outcome?

Authors: Hun Ju Lee, Andrea S. Licht, Andrew J. Hyland, Laurie A. Ford, Sheila N. J. Sait, AnneMarie W. Block, Maurice Barcos, Maria R. Baer, Eunice S. Wang, Meir Wetzler

Published in: Annals of Hematology | Issue 3/2012

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Abstract

Obesity adversely affects outcome in pediatric acute lymphocytic leukemia and acute myeloid leukemia (AML). We asked if obesity, measured by body mass index (BMI), affected outcome in 329 adult AML patients treated with high-dose cytarabine and idarubicin-containing regimens administered according to actual body weight. Age ≥ 60, unfavorable karyotype, secondary AML, and positive smoking status had adverse impact on overall survival in a multivariate analysis, while BMI did not. We conclude that high BMI should not be a barrier to administer high-dose cytarabine-containing regimens for AML induction.
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Metadata
Title
Is obesity a prognostic factor for acute myeloid leukemia outcome?
Authors
Hun Ju Lee
Andrea S. Licht
Andrew J. Hyland
Laurie A. Ford
Sheila N. J. Sait
AnneMarie W. Block
Maurice Barcos
Maria R. Baer
Eunice S. Wang
Meir Wetzler
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 3/2012
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-011-1319-8

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

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Developed by: Springer Medicine
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