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La radiologia medica

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01-01-2016 | ABDOMINAL RADIOLOGY

Is low b-factors-based apparent diffusion coefficient helpful in assessing renal dysfunction?

Authors: Jiule Ding, Jie Chen, Zhenxing Jiang, Hua Zhou, Jia Di, Shijun Xing, Wei Xing

Published in: La radiologia medica | Issue 1/2016

Abstract

Purpose

To investigate whether low b-factors-based apparent diffusion coefficient (ADC) is helpful in assessing renal dysfunction.

Materials and methods

Forty-four subjects were recruited, and classified as having severe renal injury group (sRI) or not (non-sRI) according to a threshold of estimated glomerular filtration rate (eGFR) = 30 ml/min/1.73 m². A free-breathing DWI with 7 b-factors (0, 20, 40, 80, 200, 400, and 800 s/mm²) was performed. After choosing an anatomical section that covered the largest part of right kidney, the regions of interest covered the renal parenchyma. For each subject, two apparent diffusion coefficients based on all b-factors less than 400 s/mm² (ADC_0–400) and 800 s/mm² (ADC_0–800) were calculated by fitting the signal intensity at different b-factors to a mono-exponential decay, respectively. It was found that the examination time of the free-breathing DWI sequence in this study can be reduced from 3.27 to 2.55 min if the b-factor (800 s/mm²) is removed.

Results

ADC_0–400 was larger than ADC_0–800 in each group (P < 0.05). Both ADC_0–400 and ADC_0–800 were smaller in the sRI group than those in the non-sRI group (P < 0.01), and they were linearly related with eGFR (P < 0.05). While a significant difference was not found between the two coefficients to differentiate sRI from non-sRI participants (P > 0.05), a strong correlation was present between ADC_0–400 and ADC_0–800 (r = 0.856, P < 0.001).

Conclusion

The low b-factors-based ADC was an economical option for reducing the examination time without sacrificing its diagnostic performance.

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Title: Is low b-factors-based apparent diffusion coefficient helpful in assessing renal dysfunction?
Authors: Jiule Ding
Jie Chen
Zhenxing Jiang
Hua Zhou
Jia Di
Shijun Xing
Wei Xing
Publication date: 01-01-2016
Publisher: Springer Milan
Published in: La radiologia medica / Issue 1/2016
Print ISSN: 0033-8362
Electronic ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-015-0577-2

2024 ASCO Annual Meeting

Springer Medicine

Is low b-factors-based apparent diffusion coefficient helpful in assessing renal dysfunction?

Abstract

Purpose

Materials and methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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