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Open Access 01-12-2006 | Research article

Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits

Authors: Micha Gawlik, Kerstin Moller-Ehrlich, Meinhard Mende, Michael Jovnerovski, Sven Jung, Burkhard Jabs, Michael Knapp, Gerald Stoeber

Published in: BMC Psychiatry | Issue 1/2006

Abstract

Background

A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important pathogenic factor in depression. Genetic variants of FKBP5, a protein of the HPA system modulating the glucocorticoid receptor, have been reported to be genetically associated with improved response to medical treatment and an increase of depressive episodes.

Methods

We examined three single nucleotide polymorphisms (SNPs) in FKBP5, rs4713916 in the proposed promoter region, rs1360780 in the second intron and rs3800373 in the 3'-untranslated region (3'-UTR), in a case-control study of Caucasian origin (affective psychosis: n = 248; controls: n = 188) for genetic association and association with disease related traits.

Results

Allele and genotype frequencies of rs4713916, rs1360780 and rs3800373 were not significantly different between cases and controls. Two three-locus haplotypes, G-C-T and A-T-G, accounted for 86.2% in controls. Odds ratios were not increased between cases and controls, except the rare haplotype G-C-G (OR 6.81), representing 2.1% of cases and 0.3% of controls. The frequency of rs4713916AG in patients deviated from expected Hardy-Weinberg equilibrium, the genotype AA at rs4713916 in monopolar depression (P = 0.011), and the two-locus haplotype rs1360780T – rs3800373T in the total sample (overall P = 0.045) were nominally associated with longer continuance of disease.

Conclusion

Our data do not support a significant genetic contribution of FKBP5 polymorphisms and haplotypes to affective psychosis, and the findings are inconclusive regarding their contribution to disease-related traits.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/6/52/prepub

Title: Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits
Authors: Micha Gawlik
Kerstin Moller-Ehrlich
Meinhard Mende
Michael Jovnerovski
Sven Jung
Burkhard Jabs
Michael Knapp
Gerald Stoeber
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2006
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/1471-244X-6-52

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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