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European Journal of Trauma and Emergency Surgery

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01-08-2016 | Original Article

Is Enterobius vermicularis infestation associated with acute appendicitis?

Authors: N. Akkapulu, S. Abdullazade

Published in: European Journal of Trauma and Emergency Surgery | Issue 4/2016

Abstract

Purpose

Enterobius vermicularis might be seen in specimens of patients who underwent surgery due to acute appendicitis. There is still debate as to E. vermicularis infestation causes acute appendicitis. The primary aim of this study is to determine the incidence of E. vermicularis infestation, and the secondary aim is to determine the possible role of E. vermicularis in pathogenesis of appendicitis as well as the adequacy of demographic data and laboratory values in predicting infestation preoperatively.

Methods

A retrospective investigation was conducted with all patients who underwent appendectomy due to acute appendicitis in a secondary care center. Patients with E. vermicularis were compared with 24 controls that underwent appendectomy during the same time period. Demographic data, preoperative white blood cell (WBC) count, eosinophil counts, and histopathological findings for both groups were analyzed and compared.

Results

Enterobius vermicularis was detected in the appendectomy materials in 9 of 1446 patients (0.62 %). Histopathologically, only one of nine patients had acute appendicitis while the others were diagnosed with lymphoid hyperplasia. There were no statistically significant differences between the groups except WBC count. However, the WBC count was significantly (p < 0.05) lower in the group which was detected E. vermicularis.

Conclusions

Enterobius vermicularis is rarely associated with the histopathological findings of acute appendicitis. Also eosinophil count and elevation of white blood counts are inadequate for predicting preoperative E. vermicularis.

Akbulut S, Tas M, Sogutcu N, Arikanoglu Z, Basbug M, Ulku A, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol: WJG. 2011;17(15):1961–70. doi:10.3748/wjg.v17.i15.1961.CrossRefPubMedPubMedCentral

Yildirim S, Nursal TZ, Tarim A, Kayaselcuk F, Noyan T. A rare cause of acute appendicitis: parasitic infection. Scand J Infect Dis. 2005;37(10):757–9. doi:10.1080/00365540510012161.CrossRefPubMed

Nackley AC, Nackley JJ II, Yeko TR, Gunasekaran S. Appendiceal Enterobius vermicularis infestation associated with right-sided chronic pelvic pain. JSLS: J Soc Laparoendosc Surg/Soc Laparoendosc Surg. 2004;8(2):171–3.

Wiebe BM. Appendicitis and Enterobius vermicularis. Scand J Gastroenterol. 1991;26(3):336–8.CrossRefPubMed

Engin O, Calik S, Calik B, Yildirim M, Coskun G. Parasitic appendicitis from past to present in Turkey. Iran J Parasitol. 2010;5(3):57–63.PubMedPubMedCentral

Yabanoglu H, Caliskan K, Ozgur Aytac H, Turk E, Karagulle E, Kayaselcuk F, et al. Unusual findings in appendectomy specimens of adults: retrospective analyses of 1466 patients and a review of literature. Iran Red Crescent Med J. 2014;16(2):e12931. doi:10.5812/ircmj.12931.CrossRefPubMedPubMedCentral

da Silva DF, da Silva RJ, da Silva MG, Sartorelli AC, Rodrigues MA. Parasitic infection of the appendix as a cause of acute appendicitis. Parasitol Res. 2007;102(1):99–102. doi:10.1007/s00436-007-0735-0.CrossRefPubMed

Bredesen J, Falensteen Lauritzen A, Kristiansen VB, Sorensen C, Kjersgaard P. Appendicitis and enterobiasis in children. Acta Chir Scand. 1988;154(10):585–7.PubMed

Sodergren MH, Jethwa P, Wilkinson S, Kerwat R. Presenting features of Enterobius vermicularis in the vermiform appendix. Scand J Gastroenterol. 2009;44(4):457–61. doi:10.1080/00365520802624227.CrossRefPubMed

10.

Gialamas E, Papavramidis T, Michalopoulos N, Karayannopoulou G, Cheva A, Vasilaki O, et al. Enterobius vermicularis: a rare cause of appendicitis. Turkiye parazitolojii dergisi/Turkiye Parazitoloji Dernegi = Acta parasitologica Turcica/Turk Soc Parasitol. 2012;36(1):37–40. doi:10.5152/tpd.2012.09.

11.

Isik B, Yilmaz M, Karadag N, Kahraman L, Sogutlu G, Yilmaz S, et al. Appendiceal Enterobius vermicularis infestation in adults. Int Surg. 2007;92(4):221–5.PubMed

12.

Jones PF. Suspected acute appendicitis: trends in management over 30 years. Br J Surg. 2001;88(12):1570–7. doi:10.1046/j.0007-1323.2001.01910.x.CrossRefPubMed

13.

Butler C. Surgical pathology of acute appendicitis. Hum Pathol. 1981;12(10):870–8.CrossRefPubMed

14.

Kumar V, Abbas AK, Aster JC. Robbins and Cotran pathologic basis of disease. 9th ed. Philadelphia: Elsevier Saunders; 2015.

15.

Petras RE, Gramlich TL. Vermiform appendix. In: Stacey EM, editor. Histology for pathologists. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 649–61.

16.

Arca MJ, Gates RL, Groner JI, Hammond S, Caniano DA. Clinical manifestations of appendiceal pinworms in children: an institutional experience and a review of the literature. Pediatr Surg Int. 2004;20(5):372–5. doi:10.1007/s00383-004-1151-5.CrossRefPubMed

17.

Panidis S, Paramythiotis D, Panagiotou D, Batsis G, Salonikidis S, Kaloutsi V, et al. Acute appendicitis secondary to Enterobius vermicularis infection in a middle-aged man: a case report. J Med Case Rep. 2011;5(1):559. doi:10.1186/1752-1947-5-559.CrossRefPubMedPubMedCentral

18.

Nathans AA, Merenstein H, Brown SS. Lymphoid hyperplasia of the appendix; clinical study. Pediatrics. 1953;12(5):516–24.PubMed

19.

Gray GF Jr WP. Surgical pathology of the vermiform appendix. In: Sommers SC RP, Fechner RE, editor. Pathology annual part 2. Norwalk, CT: Appleton-Century-Croft; 1986. p. 111–144.

20.

Deniz K, Sokmensuer LK, Sokmensuer C, Patiroglu TE. Significance of intraepithelial lymphocytes in appendix. Pathol Res Pract. 2007;203(10):731–5. doi:10.1016/j.prp.2007.07.003.CrossRefPubMed

21.

Aydin O. Incidental parasitic infestations in surgically removed appendices: a retrospective analysis. Diagn Pathol. 2007;2:16. doi:10.1186/1746-1596-2-16.CrossRefPubMedPubMedCentral

22.

Clark PJ. Utility of eosinophilia as a diagnostic clue in lower abdominal pain in northern Australia: a retrospective case-control study. Intern Med J. 2008;38(4):278–80. doi:10.1111/j.1445-5994.2008.01644.x.CrossRefPubMed

Title: Is Enterobius vermicularis infestation associated with acute appendicitis?
Authors: N. Akkapulu
S. Abdullazade
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Trauma and Emergency Surgery / Issue 4/2016
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-015-0555-3

At a glance: The STEP trials

Springer Medicine

Is Enterobius vermicularis infestation associated with acute appendicitis?

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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